Prevalence of Congenital Heart Defects Associated with Down Syndrome in Korea

Abstract

Congenital heart defect (CHD) is common in infants with Down syndrome (DS), which is the principle cause of mortality. However, there is no data available for the frequency and types of CHD in infants with DS in Korea. We investigated the frequency of CHD in infants with DS in Korea. After the survey on birth defects was conducted throughout the country, the prevalence of CHD in DS in 2005-2006 was calculated. This study was conducted based on the medical insurance claims database of the National Health Insurance Corporation. The number of total births in Korea was 888,263 in 2005-2006; of them, 25,975 cases of birth defects were identified. The prevalence of DS was 4.4 per 10,000 total births, accounting for 1.5% of all birth defects. Of the 394 infants with DS, 224 (56.9%) had a CHD. Atrial septal defect was the most common defect accounting for 30.5% of DS followed by ventricular septal defect (19.3%), patent duct arteriosus (17.5%), and atrioventricular septal defect (9.4%). Our study will be helpful to demonstrate the current status of DS and to identify the distribution of CHD in infants with DS in Korea.

Gender differences in the prevalence of congenital heart disease in Down’s syndrome: a brief meta-analysis

“…Direct contact with the authors of the remaining 31 articles made it possible to include another eight studies [12,13,20,[26][27][28][29][30], totalizing 12 articles for analysis. In total, 20,465 patients with DS (11,165 male and 9300 female) were included in the meta-analysis.…”

Down syndrome: Prevalence and distribution of congenital heart disease in Brazil

“…3,[5][6][7][8][9][10][11][12][13][14][15][16][17] The types of heart defect may vary according to geographic region. In this study, the most common type was atrial septal defect, which was similar to the findings from other Table 1.…”

Perfil de morbilidad en adolescentes chilenos con síndrome de Down

“…Es ampliamente conocido que el 40 a 60% de las personas con SD tienen CC 12 , en nuestra serie, las CC afectaron a cerca del 60%, frecuencia mayor a lo reportado en la literatura internacional 13,14 , debido probablemente a que nuestra institución es también un centro de referencia de cardiocirugía pediátrica. Al igual que lo reportado en la literatura, los tipos de CC predominantes fueron los defectos septales aurículo ventriculares [12][13][14][15] .…”

“…Al igual que lo reportado en la literatura, los tipos de CC predominantes fueron los defectos septales aurículo ventriculares [12][13][14][15] . En la etapa de la adolescencia cobra importancia no tan sólo el seguimiento de aquellos pacientes que requirieron cirugía (que alcanzó a la mitad de los que tuvieron CC), si no que se debiera estar atento a la aparición de soplos y desarrollo de valvulopatías.…”