Prevalence of Comorbidity between Dry Eye and Allergic Conjunctivitis: A Systematic Review and Meta-Analysis

Akasaki, Yasutsugu; Inomata, Takenori; Sung, Jaemyoung; Nakamura, Masahiro; Kitazawa, Koji; Shih, Kendrick Co; Adachi, Takeya; Okumura, Yuichi; Fujio, Kenta; Nagino, Ken; Midorikawa‐Inomata, Akie; Kuwahara, Mizu; Hirosawa, Kunihiko; Huang, Tianxiang; Morooka, Yuki; Shokirova, Hurramhon; Eguchi, Atsuko; Murakami, Akira

doi:10.3390/jcm11133643

Cited by 11 publications

(11 citation statements)

References 53 publications

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“…In a recent systematic review and meta-analysis including studies on ocular allergy and dry eye, it was found that 47.2% of the patients with AC exhibited comorbid dry eyes. [ 20 ] There is no published study on the association of AC and DED in north India which makes this study unique. Most of the studies done on AC included SAC & PAC as one entity, but in our study, we studied both the groups separately and found that in this region SAC (69/132 patients) is the most common AC.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of dry eye disease in the patients of allergic conjunctivitis: Hospital-based cross-sectional study

Mazumdar

Satsangi

Garg

et al. 2023

Indian Journal of Ophthalmology

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Purpose: Allergic conjunctivitis (AC) is commonly associated with dry eye. This study was conducted to assess the prevalence of dry eye in different subsets of AC patients. Methods: This observational, cross-sectional study, conducted in the Department of Ophthalmology of a tertiary center in north India, included 132 patients of AC. The diagnosis of dry eye disease (DED) was made on the basis of Ocular Surface Disease Index (OSDI), Schirmer’s test, and tear film break-up time (TFBUT). Results: The prevalence of dry eye in AC patients was found to range between 31% and 36%. On OSDI scoring, 20.45% of patients had mild, 18.18% moderate, and 31.81% had a severe grade of DED, respectively. The mean OSDI score was noted to be significantly higher in patients with perennial allergic conjunctivitis (PAC) (29.82 ± 12.41), followed by seasonal allergic conjunctivitis (SAC) (25.35 ± 12.88), and least in the patients of vernal keratoconjunctivitis (VKC) (13.60 ± 8.63) (p < 0.0001), respectively. The TFBUT was found to be less than 10 s in 45.45% of PAC, 30.43% of SAC, and 20% of VKC patients, respectively. The difference between the mean TFBUT among the three groups was statistically insignificant (p = 0.683). Schirmer’s test value of <10 mm was observed in 45.45% of PAC, 43.47% of SAC, and 10% of VKC patients, respectively. Conclusion: This study revealed a high prevalence of DED in patients with AC. Among the different types of AC patients, PAC had the highest percentage of DED followed by SAC and least in VKC, respectively.

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Section: Discussionmentioning

confidence: 99%

Prevalence of dry eye disease in the patients of allergic conjunctivitis: Hospital-based cross-sectional study

Mazumdar

Satsangi

Garg

et al. 2023

Indian Journal of Ophthalmology

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“…DE had co-morbid AC. 21 Nevertheless, allergic reactions secondary to SED are infrequently described. Only Lekhanont et al 5 recorded what they considered to be an allergic reaction to SED-which was autologous!…”

Section: Discussionmentioning

confidence: 99%

“…Allergic eye disease commonly follows exposure to environmental allergens, such as pollen and dust mites, followed by binding of antigen by specific IgE on the surface of conjunctival mast cells, and then mast cell degranulation 20 . Furthermore, a study found that dry eye (DE) is a frequent co‐morbidity in patients with allergic conjunctivitis (AC) and vice versa: the authors estimated that 17.8% of those with DE had co‐morbid AC 21 . Nevertheless, allergic reactions secondary to SED are infrequently described.…”

Section: Discussionmentioning

confidence: 99%

Reactions to serum eye drops—New Zealand experience and review of the literature

Badami,

McKellar

2023

Transfusion Medicine

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BackgroundSerum eye drops (SED) are used to treat ocular surface disease. Reactions to SED are poorly documented.MethodsWe present our experience of self‐reported reactions in New Zealand to SED (25%; autologous, allogeneic, or both) between 2003 and 2023, and a focused review of the literature.ResultsIn total, 1067 patients received SED treatment (562 autologous, 318 allogeneic, and 187 both). Three (0.5% of those treated with allogeneic SED) reported reactions. All appeared to be allergic. All were associated with allogeneic SED. We have information on two patients: one had an eye reaction; in the other, the gastrointestinal tract was involved. The literature contains few reports of reactions to SED. They have involved both autologous and allogeneic SED, and various SED concentrations. None appears to have been severe. Notably, no eye or systemic infections have been reported.ConclusionsInformation on the types and frequencies of reactions to SED is poor. This may be due to: serum being less likely to cause reactions; eyes being resistant to reactions; reactions being rare, and insufficient use of SED having occurred; under‐reporting related to SED use at home and reactions being mild. More robust monitoring for reactions to SED is needed.

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“…(1) patients with other types of AC, including AKC, VKC, and GPC; (2) patients who underwent any other infectious in ammation or ocular immunological diseases other than SAC/PAC and DE, such as uveitis, blepharitis, Sjögren's syndrome (SS) and ocular graft-versus-host disease (oGVHD), etc. 3 individuals who had undergone ocular surgery within three months preceding the trial; (4) patients using topical or systemic steroid, anti-allergic or immunosuppressive drugs within one month of inclusion in the study; (5) For tear proteomics analysis, we further excluded subjects with insu cient tear sample size.…”

Section: • Study Design and Participantsmentioning

confidence: 99%

“…2,3 Studies have shown that the prevalence of DE in patients with AC is 31.3% and even up to 47.2% in a recent meta-analysis. 4,5 In southwest China, the prevalence of DE among children with AC has reached 97.5%. 6 Previously, the major treatment options required a combination of multiple medications.…”

Section: Introductionmentioning

confidence: 99%

Exploration of Efficacy and Mechanism of 0.05% Cyclosporine Eye Drops (II) Monotherapy in Allergic Conjunctivitis-associated Dry Eye

Jiao,

Qi,

Gao

et al. 2023

Preprint

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Purpose To explore the efficacy and relevant mechanism of 0.05% cyclosporine A (CsA) eye drops (II) monotherapy in patients with allergic conjunctivitis-associated dry eye (ACDE). Methods Prospective, randomized, controlled study. Fifty-three patients with mild-to-moderate ACDE were randomly assigned to two groups. The CsA group received 0.05% CsA eye drops (II) monotherapy four times daily. The control group received 0.1% olopatadine twice daily combined with 0.1% preservative-free artificial tears four times daily. Clinical symptoms and signs, tear total IgE, and lymphotoxin-α (LT-α) concentrations were assessed at pre- and post-treatment days 7, 30, and 60. And we further measured six tear inflammatory cytokines levels using a microsphere-based immunoassay. Results The CsA group showed significant improvement in symptoms (Ocular Surface Disease Index and itching scores) and signs (conjunctival hyperemia, conjunctival edema, conjunctival papillae, tear break-up time (TBUT), corneal fluorescent staining, and goblet cell density) at each follow-up period compared to pre-treatment (all P<0.050). And its improvement in itching scores (P7th<0.001, P30th=0.039, and P60th=0.031) and TBUT (P7th=0.009, P30th=0.003, and P60th=0.005) was more significant than the control group at all follow-up periods. The tear total IgE, interleukin (IL)-5, IL-6, periostin, eotaxin-3, and MMP-9 levels significantly decreased in the CsA group at day 60 after treatment (all P<0.050). And the changed values in tear total IgE were positively correlated with the change in itching scores. Conclusions 0.05% CsA eye drops (II) monotherapy can rapidly improve the symptoms and signs, especially in ocular itching and TBUT, in patients with ACDE. And its efficacy is superior to 0.1% olopatadine combined with artificial tears. Moreover, CsA downregulates the expression levels of tear inflammatory cytokines, including tear total IgE, IL-5, IL-6, periostin, eotaxin-3, and MMP-9. Among that, the reduction in tear total IgE levels may reflect the improvement of ocular itching.

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Prevalence of Comorbidity between Dry Eye and Allergic Conjunctivitis: A Systematic Review and Meta-Analysis

Cited by 11 publications

References 53 publications

Prevalence of dry eye disease in the patients of allergic conjunctivitis: Hospital-based cross-sectional study

Prevalence of dry eye disease in the patients of allergic conjunctivitis: Hospital-based cross-sectional study

Reactions to serum eye drops—New Zealand experience and review of the literature

Exploration of Efficacy and Mechanism of 0.05% Cyclosporine Eye Drops (II) Monotherapy in Allergic Conjunctivitis-associated Dry Eye

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