Prevalence of Common Respiratory Viral Infections and Identification of Adenovirus in Hospitalized Adults in Harbin, China 2014 to 2017

Wang, Yingchen; Dong, Tuo; Qi, Guiyun; Qu, Lixin; Liang, Wei; Qi, Binbin; Zhang, Zhe; Shang, Lei; Gao, Hong; Du, Xiqiao; Lu, Bing; Guo, Yan; Liu, Zhenwei; Yu, Huisong; Cui, Qi; Wang, Xiaocen; Li, Ye; Wei-yuan, Guo; Qu, Zhengyi

doi:10.3389/fmicb.2018.02919

Cited by 13 publications

(9 citation statements)

References 49 publications

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“…Adenovirus infections can occur endemically throughout the year. Contrary to previous reports, [14][15][16] this study showed that summer and winter were the predominant epidemic seasons in Chongqing, China. The differences in seasonal epidemic occurrence were likely due to different serotypes and variations in climates between different countries or regions.…”

Section: Discussioncontrasting

confidence: 99%

The difference in clinical features and prognosis of severe adenoviral pneumonia in children of different ages

Wang

Tan

2022

Journal of Medical Virology

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This study aims to analyze the difference in clinical features and prognosis of severe adenovirus pneumonia (SAP) in children of different ages and analyze the risk factors for poor prognosis in children with SAP. A retrospective observational study was performed to describe the clinical features and analyze the risk factors for death and postinfectious bronchiolitis obliterans (PIBO) in 303 children hospitalized with SAP from January 2015 through to January 2020. The participants were divided into four age groups: <6 months (n = 25, 8.3%); 6-12 months (n = 98, 32.3%); 12-36 months(n = 118, 38.9%); and >36 months (n = 62, 20.5%). Fever rate, peak, and duration were the lowest in the <6 months group, while no significant difference was found among other age groups. Serum levels of lactate dehydrogenase and a load of adenovirus were the lowest in the <6 months group, and the highest in the 6-12 and 12-36 months groups, respectively. A total of 80.9% of patients recovered, 3.3% of patients died, and 15.8% of patients were diagnosed with PIBO. The mortality rate showed no significance between age groups. The >36 months group had the highest recovery rate and the lowest incidence of PIBO, while the 6-12 months group had the lowest recovery rate and the highest incidence of PIBO. Independent risk factors for PIBO among all participants from the four groups were invasive mechanical ventilation, administration of intravenous steroids, duration of fever, and male gender. Independent risk factors for death among all participants from the four groups were hypercapnia, low albumin levels, and invasive mechanical ventilation.Risk factor analysis of different ages was not possible due to the limited sample size.The morbidity, clinical features, and prognosis of SAP are affected by children's ages.Pediatric patients with a longer duration of fever, hypercapnia, low serum albumin levels, invasive mechanical ventilation, and intravenous steroids use are more likely to develop a poor prognosis in SAP, especially if the patient is male.

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Section: Discussioncontrasting

confidence: 99%

The difference in clinical features and prognosis of severe adenoviral pneumonia in children of different ages

Wang

Tan

2022

Journal of Medical Virology

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“…This is similar to the findings of Wu et al We speculate that the high positive rate of ADV in children 3-6 years of age was because they were in kindergarten in Hangzhou and prone to cross-infection. According to another study on ADV prevalence in adults in Harbin, China, ADV incidence typically was highest in the spring, followed by winter [ 17 ]. A study conducted in Mainz, Germany [ 18 ], showed a negative correlation between ADV infection and temperature, which was similar to the results reported in Harbin.…”

Section: Discussionmentioning

confidence: 99%

Exploring the epidemiological changes of common respiratory viruses since the COVID-19 pandemic: a hospital study in Hangzhou, China

Zhu

et al. 2021

Arch Virol

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Adenovirus, respiratory syncytial virus, and influenza virus are common causes of respiratory infections. The COVID-19 pandemic had a significant impact on their prevalence. The aim of this study was to analyze the epidemic changes of common respiratory viruses in the Affiliated Hospital of Hangzhou Normal University in Hangzhou, China, from October of 2017 to February of 2021. We collected statistics from 121,529 patients in the outpatient and inpatient departments of the hospital who had throat or nose swabs collected for testing for four virus antigens by the colloidal gold method. Of these, 13,200 (10.86%) were positive for influenza A virus, 8,402 (6.91%) were positive for influenza B virus, 6,056 (4.98%) were positive for adenovirus, and 4,739 (3.90%) were positive for respiratory syncytial virus. The positivity rates of the influenza A virus (0-14 years old, P = 0.376; over 14 years old, P = 0.197) and respiratory syncytial virus (0-14 years old, P = 0.763; over 14 years old, P = 0.465) did not differ significantly by gender. After January of 2020, influenza virus infection decreased significantly. The positivity rate of respiratory syncytial virus remained high, and its epidemic season was similar to before. Strict respiratory protection and regulation of crowd activities have a great impact on the epidemic characteristics of viruses. After major changes in the public health environment, virus epidemics and their mutations should be monitored closely, extensively, and continuously.

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“…IFA and real-time PCR offer advantages in terms of speed, and the diagnosis of HAdV infection can be completed within 2 h[16, 18]. Detection of HAdVs in nasopharyngeal swab samples by IFA is well-established and commonly used[19]. Monoclonal antibodies (mAbs) employed by IFA to detect HAdVs should ideally target highly conserved epitope types.…”

Section: Introductionmentioning

confidence: 99%

Development of two antigen-binding fragments to a conserved linear epitope of human adenovirus and their application in immunofluorescence

Liu¹,

Tian²,

Liu³

et al. 2019

PLoS ONE

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Detection of human adenoviruses (HAdVs) in nasopharyngeal swab samples by immunofluorescence assay (IFA) will be valuable for diagnosing HAdV infection, which is a leading cause of severe respiratory tract disease, and will help in curbing the spread of HAdV. Monoclonal antibodies employed in IFA for HAdV detection should ideally target highly conserved epitope types. Here, we describe the development of two antigen-binding fragments (Fabs) with specific reactivity to HAdV using phage antibody library technology. When tested with IFA, both Fabs recognized cells infected with several types of HAdV, some of which have been identified in epidemics globally, or associated with outbreaks of severe or fatal acute respiratory diseases. The specificity and cross-reactivity of both Fabs to HAdVs indicated that the generated Fabs could be applied in the development of IFAs to detect HAdVs. Both Fabs bound to the knob proteins, as shown by chemiluminescence enzyme immunoassay and western blot. In addition, epitope mapping showed that both Fabs recognized a conserved linear epitope among several types of HAdV. Two different Fabs recognized the same epitope, suggesting that the epitope triggered the production of at least two kinds of antibodies in the body. The generated Fabs exerted no neutralization against HAdVs. The results demonstrate that both Fabs bind to an epitope that plays no role in neutralization of HAdV.

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Prevalence of Common Respiratory Viral Infections and Identification of Adenovirus in Hospitalized Adults in Harbin, China 2014 to 2017

Cited by 13 publications

References 49 publications

The difference in clinical features and prognosis of severe adenoviral pneumonia in children of different ages

The difference in clinical features and prognosis of severe adenoviral pneumonia in children of different ages

Exploring the epidemiological changes of common respiratory viruses since the COVID-19 pandemic: a hospital study in Hangzhou, China

Development of two antigen-binding fragments to a conserved linear epitope of human adenovirus and their application in immunofluorescence

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