Prevalence of common nosocomial organisms in surgical intensive care unit in North India: A hospital-based study

Taj, Arshi; Shamim, Anjum; Khanday, Shoiab Bashir; Ommid, Mohamad

doi:10.4103/ijciis.ijciis_8_18

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…In Asian countries like India, Pseudomonas spp. have been the most common organism isolated from ICUs [ 4 , 5 , 12 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

Insight into the Burden of Antimicrobial Resistance among Bacterial Pathogens Isolated from Patients Admitted in ICUs of a Tertiary Care Hospital in India

Gautam,

Satija,

Kaur

et al. 2024

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Intensive care unit (ICU) patients are prone to develop infections by hospital prevalent organisms. The aim of the study was to determine the bacteriological profiles and their drug resistance pattern among different infections in ICU patients of a tertiary care hospital. The record-based retrospective data of culture reports of the patients admitted to all the ICUs of a tertiary care hospital during the period from January 2020 to May 2022 were analyzed. A total of 3,056 samples were obtained from 2308 patients. The infection rate among ICU patients was found to be 53.40%. Isolates belonged equally to males (50.86%) and females (49.14%). The most common culture-positive clinical specimen received was blood (39.08%) followed by respiratory samples (29.45%). Acinetobacter sp. (33.02%) was the most common organism isolated from various clinical specimens, followed by Klebsiella pneumoniae (20.89%), and Escherichia coli (13.8%). More than 80% of Acinetobacter species were found to be resistant to third-generation cephalosporins, aminoglycosides, and carbapenems, whereas minocycline (56.31% S) and colistin (100% S) were the most effective drugs. Klebsiella sp. was found to be more resistant than E.coli, and the least resistance was observed to be tetracycline (43.97%) and doxycycline (55.84%). Among Staphylococcus aureus, 82.78% of strains were methicillin-resistant (MRSA). Vancomycin-resistant Enterococci (VRE) sp. accounted for 16.67% of the isolates. Evidence-based knowledge regarding the local bacterial organisms and their antimicrobial resistance pattern is pivotal in deciding empirical drug therapy, ultimately leading to the management of antimicrobial resistance (AMR).

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“…In Asian countries like India, Pseudomonas spp. have been the most common organism isolated from ICUs [ 4 , 5 , 12 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

Insight into the Burden of Antimicrobial Resistance among Bacterial Pathogens Isolated from Patients Admitted in ICUs of a Tertiary Care Hospital in India

Gautam,

Satija,

Kaur

et al. 2024

Canadian Journal of Infectious Diseases and Medical Microbiolog

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In vitro Study on the Efficacy of Silver Nanoparticles against Metallo-Beta-Lactamase and Biofilm Producing Pseudomonas aeruginosa Isolates

Bahey¹,

Enany²,

Hamid³

et al. 2019

Int.J.Curr.Microbiol.App.Sci

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In vitro activity of tigecycline against local clinical isolates of some Enterobacteriaceae

Eldeeb

Serry

Ghoname

et al. 2020

Zagazig Journal of Pharmaceutical Sciences

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Infectious diseases that Enterobacteriaceae cause are spreading on a wide scale. Examples of these infections are gastrointestinal tract infections, meningitis, pneumonia, septicemia, urinary tract infections, and wound infections. Antibiotic resistance among Enterobacteriaceae is a critical problem that makes treatment difficult. Tigecycline is a broad spectrum antibiotic that is effective against multi-drug resistant organisms (MDR) and may be beneficial in the therapy of infections caused by Enterobacteriaceae. This study aims to evaluate the in vitro activity of tigecycline against clinical isolates of Enterobacteriaceae species and detect the possible resistance mechanisms of them against βlactams. The sensitivity of different isolates to antibiotics was determined by standard disc diffusion method. Phenotypic detection of resistance mechanisms such as extended spectrum β-lactamase (ESBL), AmpC, ESBL& AmpC co-producers and metallo β-lactamase (MBL) β-lactamases enzymes producer isolates was investigated. A total of eighty three Enterobacteriaceae clinical isolates were collected. The common bacteria isolated were Escherichia coli and Klebsiella pneumoniae. Multidrug resistance was found in 59.04% of tested isolates. The isolates were resistant to sulfamethoxazole-trimethoprim, ciprofloxacin, tetracycline and impenem. The highest resistance was found to sulfamethoxazoletrimethoprim followed by ciprofloxacin, tetracycline and imipenem. Phenotypic detection of resistance mechanisms revealed that 69.4% of clinical isolates were ESBL producers, 12.2% were AmpC producers, and 8.2% were ESBL and AmpC co-producers, while 10.2% were MBL producers. There was no resistance found to tigecycline among all Enterobacteriaceae isolates tested. This study showed that tigecycline has potent in vitro activity against ESBL, AmpC, combined ESBL and AMPC and MBL β-lactamases producing Enterobacteriaceae.

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Prevalence of common nosocomial organisms in surgical intensive care unit in North India: A hospital-based study

Cited by 3 publications

References 17 publications

Insight into the Burden of Antimicrobial Resistance among Bacterial Pathogens Isolated from Patients Admitted in ICUs of a Tertiary Care Hospital in India

Insight into the Burden of Antimicrobial Resistance among Bacterial Pathogens Isolated from Patients Admitted in ICUs of a Tertiary Care Hospital in India

In vitro Study on the Efficacy of Silver Nanoparticles against Metallo-Beta-Lactamase and Biofilm Producing Pseudomonas aeruginosa Isolates

In vitro activity of tigecycline against local clinical isolates of some Enterobacteriaceae

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