Prevalence of Colorectal Polyps Based on Cardiorespiratory Fitness, Muscle Strength, Health Behavior, and Abdominal Obesity in Asymptomatic Elderly

Abstract

Colorectal polyps are precursor lesions of colorectal cancer and are known to be associated with obesity, low physical activity, and unhealthy behavior. This cross-sectional study analyzed the prevalence of colorectal polyps based on cardiorespiratory fitness (CRF), muscle strength, and health behavior in older adults. Participants were asymptomatic and included 1024 men and 472 women aged 65–80 years who visited the health care center. Colonoscopy was performed under conscious sedation, and cardiorespiratory fitness was measured as the maximum oxygen uptake using gas analysis. Muscle strength was determined using isokinetic equipment, and physical activity, alcohol consumption, and smoking status were investigated using questionnaires. Waist circumference was measured at the thickest part of the middle of the abdomen. Logistic regression analysis was used to calculate the prevalence of colorectal polyps using odds ratios (ORs) based on the variables. The incidence of colorectal polyps was 65.2% in men and 48.5% in women. The ORs of colorectal polyps for obesity were 1.151 (95% confidence interval [CI], 1.010–2.291) and 1.178 (95% CI, 1.015–2.612) in men and women, respectively. The OR for colorectal polyps in male current smokers was 1.884. The ORs for low CRF were 1.985 and 1.841 in men and women, respectively, compared with high CRF. The prevalence of polyps increased with low muscle strength (men’s OR 1.343 women’s OR 1.440) and physical activity in both men (OR 1.693) and women (OR 1.861). In conclusion, lower CRF and muscle strength were associated with an increased prevalence of colorectal polyps in men and women. In both sexes, high waist circumference and low physical activity increased the prevalence of colorectal polyps.

The Association between Anthropometric Indicators and Colorectal Polyps and Diverticulosis

“…53,54 The mechanism of this effect is unknown, but it can lead to decreased insulin levels, systemic inflammation, and abdominal obesity. 53,55 Finally, similar to other studies, [56][57][58] we indicated that patients with a positive family history of diverticulitis are at higher risk for diverticulitis. This phenomenon might be explained by the fact that some genes, such as LAMB4, TNFSF15, ARHGAP15, ANO1, ELN, and SPINT2, play known roles in processes logically related to diverticulitis, including inflammation, intestinal transport, intestinal motility, and extracellular matrix formation.…”

MAFLD with central obesity is associated with increased risk of colorectal adenoma and high-risk adenoma

“…Current data collectively demonstrated that patients with MAFLD who had concomitant obesity or central obesity had a 1.28- or 6.00-fold significantly increased risk of colorectal adenoma, respectively. Similarly, Zhang S et al reported that obesity, especially central obesity, increases the incidence of colorectal polyps and that central obesity is independently associated with the development of adenomatous polyps [ 39 ]. Moreover, increased BMI has been found to increase the risk of CRC [ 40 ].…”

Virtual colonoscopy and fibrocolonoscopy in colorectal polyp patients

“…Посредством колоноскопия се открива заболяемост от колоректални полипи от 65,2% сред 1024-ма мъже и от 48,5% сред 472 жени на възраст между 65 и 80 г. (23). Отношението на шансовете спрямо затлъстяването е 1,151 (между 1,010 и 2,291 при доверителен интервал от 95%) при мъжете и 1,178 (между 1,015 и 2,612 при доверителен интервал от 95%) при жените.…”