Prevalence of cognitive impairment and its relation to mental health in Danish lymphoma survivors

Mariegaard, Johanna; Wenstrup, Jonathan; Lim, Kevin Zi Ming; Bidstrup, Pernille Envold; Heymann, Annika von; Johansen, Christoffer; Knudsen, Gitte M.; Law, Ian; Specht, Lena; Stenbæk, Dea Siggaard

doi:10.1007/s00520-020-05857-4

Cited by 5 publications

(3 citation statements)

References 39 publications

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“…Two studies examined cognitive functioning and suggested a significant relationship. Survivors with impaired cognitive functioning reported greater symptoms of distress, anxiety, stress, poor sleep quality and lower QOL compared to survivors without impaired cognitive functioning 63 . Additionally, some survivors in early aftercare reported that having cognitive problems made them feel like a burden to their partners 59 …”

Section: Resultsmentioning

confidence: 99%

Factors of emotional distress in lymphoma: A systematic review

2023

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Objective Distress is prevalent among lymphoma patients/survivors. Current processes of distress identification rely on self‐reporting by patients/survivors, which may be limited by their willingness to report symptoms. To help identify patients/survivors at greater risk, this systematic review aims to comprehensively review factors that may contribute to distress in lymphoma patients/survivors. Methods PubMed was systematically searched for peer‐reviewed primary articles (1997–2022) consisting of standardised keywords “lymphoma” and “distress.” Information from 41 articles was integrated via narrative synthesis. Results Consistent risk factors of distress include younger age, relapsed disease, and greater comorbidities and symptom burden. Active treatment and the transition from treatment to post‐treatment could be challenging phases. Adequate social support, adaptive adjustment to cancer, engaging in work and healthcare professionals' support may mitigate distress. There is some evidence that older age may be associated with greater depression and life changes/experiences may shape how individuals cope with lymphoma. Gender and marital status were not robust predictors of distress. Other clinical, psychological and socioeconomic factors are understudied or have mixed findings. Conclusions While several factors of distress align with that of other cancers, more research is needed to identify significant factors of distress in lymphoma patients/survivors. The identified factors may support clinicians in identifying distressed lymphoma patients/survivors and providing interventions where necessary. The review also highlights avenues for future research and a need to routinely collect data on distress and its factors in registries.

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Section: Resultsmentioning

confidence: 99%

Factors of emotional distress in lymphoma: A systematic review

2023

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“…A significant proportion of clinical trials were performed among solid cancer patients (the most common type of breast cancer). However, most clinical trials in hematological disorders focus on survivors of acute lymphoblastic leukemia and primary central nervous system lymphoma [6,30].33 There are few published data available on HL survivors [6,11,12,31].…”

Section: Discussionmentioning

confidence: 99%

“…Treatment completion of HL survivors was 6 months to 5 years [12]. Mariegaard et al published that 39% of lymphoma survivors (115 patients, 65 with HL) showed impairment on executive function tests made with self-reported cognitive questionnaires (the mean period time elapsed after the completion of treatment was 29.6 months [31]. The remarkable differences between executive functions might be related to the period time elapsed from the treatment.…”

Section: Discussionmentioning

confidence: 99%

Assessment of cognitive function in long-term Hodgkin lymphoma survivors, results based on data from a major treatment center in Hungary

Magyari

Virga

Simon

et al. 2022

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Introduction Nowadays, more than 80% of newly diagnosed classical Hodgkin lymphoma (HL) patients can be cured and become long-term survivors due to risk and response-adapted treatment strategies. A well-known side effect is cognitive dysfunction that appears in HL patients after chemotherapy. In the present study, we aimed to measure cognitive dysfunction in our HL patients in this study and to find potential correlations between patient-related factors, the signs and symptoms of their diseases, or therapeutic factors. Methods We carried out a computer-assisted assessment (CANTAB) of cognitive dysfunction in 118 patients. We examined the domains of visual memory, attention, working memory, and planning. Results The median age of 64 females and 54 males at diagnosis was 29 (13–74) and 41 (21–81) years at the completion of CANTAB. Fifty-two percent of all patients showed cognitive impairment. Attention was impaired in 35% of patients, the working memory and planning were impaired in 25%, while visual memory was affected in 22%. All the three functions showed a significant association with inactive employments status. A close correlation was found between visual memory/working memory and planning, higher age at HL diagnosis or the completion of CANTAB test, and disability pensioner status. Discussion Our investigation suggests that patients with inactive employment status and older age require enhanced attention. Their cognitive function and quality of life can be improved if they return to work or, if it is not possible, they receive a cognitive training.

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Effects of Baduanjin exercise on cognitive function and cancer-related symptoms in women with breast cancer receiving chemotherapy: a randomized controlled trial

Wei

Yuan

Yang

et al. 2022

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Purpose Cognitive decline is one of the main side effects of breast cancer patients after relevant treatment, but there is a lack of clear measures for prevention and management without de nite mechanism. Moreover, postoperative patients also have a need for limb rehabilitation. Whether the cognitive bene ts of Baduanjin exercise can improve the overall well-being of this breast cancer patients remains unknown. This study aims to gure out these problems in the under-researched Chinese population.Methods This randomized controlled trial was conducted on 70 patients with breast cancer undergoing chemotherapy who were randomly assigned and allocated to (1:1) the supervised Baduanjin group (5 times/week, 30 min each time) or the control group for three months. The effects of Baduanjin exercise intervention were evaluated by outcome measures including subjective cognitive function, symptoms (fatigue, depression and anxiety) and health-related quality of life at pre-intervention (T0), 4 weeks (T1), 8 weeks (T2) and 12 weeks (T3). The collected data were analyzed by using an intention-to-treat principle and linear mixed-effects modeling.Results Participants in the Baduanjin group had a signi cantly greater improvement in terms of FACT-cog (F=14.511; P < 0.001), PCI (F=15.915; P < 0.001), PCA (F=2.767; P= 0.047), and health-related quality of life (F=8.900; p = 0.004) compared with the control group over the time. The exercise-cognition relationship was signi cantly mediated by reduced fatigue (indirect effect: β= 0.132; 95% CI: 0.046, 0.237) and improved anxiety (indirect effect: β=-0.075; 95% CI: -0.165, -0.004).Conclusions This pilot study revealed the bene ts and outlined the underlying mediating mechanism of Baduanjin exercise to the subjective cognition and health-related quality of life of Chinese breast cancer patients receiving chemotherapy. The ndings provided insights into the development of public health initiatives to promote brain health and improve quality of life among breast cancer patients. Trial registration number ChiCTR 2000033152

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Prevalence of cognitive impairment and its relation to mental health in Danish lymphoma survivors

Cited by 5 publications

References 39 publications

Factors of emotional distress in lymphoma: A systematic review

Factors of emotional distress in lymphoma: A systematic review

Assessment of cognitive function in long-term Hodgkin lymphoma survivors, results based on data from a major treatment center in Hungary

Effects of Baduanjin exercise on cognitive function and cancer-related symptoms in women with breast cancer receiving chemotherapy: a randomized controlled trial

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