Prevalence of coeliac disease in patients with non-alcoholic fatty liver disease

Bakhshipour, Alireza; Kaykhaei, Mahmoud Ali; Moulaei, Nezarali; Mashhadi, Mohammad Ali

doi:10.1016/j.ajg.2013.08.001

Cited by 19 publications

(11 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Individuals with NAFLD also have a higher prevalence of CD [ 18 ]. On liver biopsy, NAFLD-defining lesions include a certain degree of steatosis with lobular inflammation, portal inflammation, hepatocyte ballooning and/or fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Glycogenic Hepatopathy: Thinking Outside the Box

Parmar

Atiq

Lee

et al. 2015

Case Rep Gastroenterol

View full text Add to dashboard Cite

Glycogenic hepatopathy (GH) remains underrecognized in adults as most clinicians mistake it for the more common hepatic abnormality associated with uncontrolled diabetes mellitus in this age group, non-alcoholic fatty liver disease. This is also complicated by the fact that both entities are indistinguishable on liver ultrasound. We herein describe a similar predicament in which a young adult female presented with bilateral upper quadrant abdominal pain, tender hepatomegaly, lactic acidosis and a >10-fold increase in liver enzymes, which worsened after the administration of high-dose steroids. Despite intravenous normal saline resuscitation, serum transaminitis persisted in a fluctuating manner. Ultimately, a liver biopsy confirmed GH. Biochemically, GH is driven by high amounts of both circulating glucose and insulin or by the administration of high-dose steroids. Improving glycemic control is the mainstay of treatment for GH. However, in our case, improvement in glycated hemoglobin of just 0.6% was enough to achieve symptomatic relief, supporting recent claims of the involvement of other identified factors in disease development.

show abstract

Section: Discussionmentioning

confidence: 99%

Glycogenic Hepatopathy: Thinking Outside the Box

Parmar

Atiq

Lee

et al. 2015

Case Rep Gastroenterol

View full text Add to dashboard Cite

show abstract

“…It is important to underline that, despite improvements in body weight (weight gain in underweight patients and weight loss in overweight patients), patients with a normal weight usually gain weight. In fact, an increase in the average BMI was observed in all studies found (Table 1) [19][20][21][35][36][37]. In patients with CD on a GFD, the increase in BMI is probably linked to the increased intake of calories, fats and simple carbohydrates, but probably also to reduced physical activity.…”

Section: Discussionmentioning

confidence: 96%

“…The prevalence of NASH is lower, ranging from 3% to 5% [18,19]. Furthermore, NAFLD patients have a higher risk of a new diagnosis of CD compared to the general population [20,21], despite celiac patients having a lower risk for metabolic syndrome before the start of a GFD [20].…”

Section: Introductionmentioning

confidence: 99%

Celiac Disease, Gluten-Free Diet, and Metabolic and Liver Disorders

et al. 2020

View full text Add to dashboard Cite

Celiac disease (CD) is a chronic autoimmune enteropathy triggered by the ingestion of gluten in genetically predisposed individuals. At the time of diagnosis, the frequency of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis in individuals with CD appears to be similar to that of the general population, although a lower body mass index and a lower rate of hypercholesterolemia and type 2 diabetes mellitus are observed at diagnosis in CD patients. The effect of a gluten-free diet (GFD) in individuals with these liver and metabolic disorders is still a matter of debate. The aim of this study was to investigate the links between a GFD and metabolic/liver disorders in CD patients. A systematic electronic search of the literature from January 2009 to December 2019 was performed using Medline, Web of Science, Scopus, and the Cochrane Library. Only papers written in English concerning metabolic and liver disorders in adult patients with CD were included. Out of 1195 citations, 14 eligible studies were identified. Increases in the frequency of NAFLD, weight gain, and alterations of the lipid profile suggest that important changes happen in celiac patients on a GFD, though the physiopathology of these conditions is unclear. Although a GFD is the only effective treatment available for CD, liver function, body weight, and metabolic and nutritional profiles should be monitored in patients on a GFD.

show abstract

“…Individuals with CD are at an increased risk of NAFLD compared with the general population[ 155 ]. Among patients with hypertransaminasemia and biopsy-proven NAFLD, approximately 3%, in whom liver enzymes normalize after 6 mo of a gluten-free diet, present with CD[ 156 - 159 ]. The association between NASH cirrhosis and refractory CD has been reported[ 160 ].…”

Section: Nafldmentioning

confidence: 99%

To screen or not to screen? Celiac antibodies in liver diseases

Narciso-Schiavon

Schiavon

2017

WJG

View full text Add to dashboard Cite

Celiac disease (CD) is a systemic immune-mediated disorder triggered by dietary gluten in genetically predisposed individuals. The typical symptoms are anemia, diarrhea, fatigue, weight loss, and abdominal pain. CD has been reported in patients with primary sclerosing cholangitis, primary biliary cholangitis, autoimmune hepatitis, aminotransferase elevations, nonalcoholic fatty liver disease, hepatitis B, hepatitis C, portal hypertension and liver cirrhosis. We evaluate recommendations for active screening for CD in patients with liver diseases, and the effect of a gluten-free diet in these different settings. Active screening for CD is recommended in patients with liver diseases, particularly in those with autoimmune disorders, steatosis in the absence of metabolic syndrome, noncirrhotic intrahepatic portal hypertension, cryptogenic cirrhosis, and in the context of liver transplantation. In hepatitis C, diagnosis of CD can be important as a relative contraindication to interferon use. Gluten-free diet ameliorates the symptoms associated with CD; however, the associated liver disease may improve, remain the same, or progress.

show abstract

Prevalence of coeliac disease in patients with non-alcoholic fatty liver disease

Cited by 19 publications

References 23 publications

Glycogenic Hepatopathy: Thinking Outside the Box

Glycogenic Hepatopathy: Thinking Outside the Box

Celiac Disease, Gluten-Free Diet, and Metabolic and Liver Disorders

To screen or not to screen? Celiac antibodies in liver diseases

Contact Info

Product

Resources

About