Prevalence of coeliac disease in diabetic children and adolescents

Koletzko, Sibylle; Bürgin-Wolff, A; Koletzko, Berthold; Knapp, Michael; Burger, Walter; Grüneklee, D.; Herz, G.; Ruch, W.; Thon, A.; Wendel, U.

doi:10.1007/bf00445915

Cited by 88 publications

(70 citation statements)

References 30 publications

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“…ith the advent of sensitive and specific serological testing, it is clear that celiac disease is more common than previously thought (1)(2)(3). In children with type 1 diabetes, prevalence rates are in the region of 1-10% compared with 0.01-0.03% in the general population (1)(2)(3)(4)(5)(6).…”

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confidence: 99%

A Longitudinal Study of the Effects of a Gluten-Free Diet on Glycemic Control and Weight Gain in Subjects With Type 1 Diabetes and Celiac Disease

et al. 2002

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OBJECTIVE—To describe the longitudinal growth characteristics and glycemic control in type 1 diabetic children diagnosed with celiac disease and started on a gluten-free diet (GFD). RESEARCH DESIGN AND METHODS—Data on growth and glycemic control for 11 case subjects diagnosed with celiac disease (cd+ group) and started on a GFD were collected prospectively, and two control subjects without celiac disease matched for age, sex, and duration of diabetes (cd− group) were selected for comparison. RESULTS—In the period between diagnosis of type 1 diabetes and start of a GFD in the cd+ compared with the cd− group, BMI standard deviation score (SDS) was lower (–0.2 vs. 0.7, P = 0.015), as was HbA1c (8.9 vs. 9.8%, P = 0.002). In a regression model the cd+ group had lower BMI SDS (P < 0.001) and lower HbA1c (P = 0.04), independent of other variables. On a GFD, BMI SDS increased by 12 months in the cd+ group and then was no different than the cd− group (1.1 vs. 1.0, P = 0.11), whereas HbA1c improved further within case subjects compared with pre-GFD (8.9 vs. 8.3%, P = 0.002). On a GFD, case subjects in contrast to control subjects showed no deterioration in HbA1c during the years of puberty (8.3 vs. 10.0%, P = 0.022) CONCLUSIONS—In children with type 1 diabetes, untreated celiac disease resulted in lower BMI SDS and lower HbA1c. Recovery of BMI SDS with a GFD was associated with further improvement in HbA1c as compared with pre-GFD, with no expected deterioration in glycemic control during puberty. These apparent clinical benefits need confirming by larger studies.

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confidence: 99%

A Longitudinal Study of the Effects of a Gluten-Free Diet on Glycemic Control and Weight Gain in Subjects With Type 1 Diabetes and Celiac Disease

et al. 2002

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“…All patients reported either partial or complete resolution of their complaints (including musculoskeletal symptoms) upon initiation of the GFD. Ten of the 36 newly diagnosed patients (patients 14,19,20,21,24,26,28,31,34, and 36) never needed any medications and reported complete resolution of their symptoms with the restriction of gluten.…”

Section: Resultsmentioning

confidence: 99%

“…1 In children ages 2.5 to 15 years this prevalence has been reported as between 0.3% and 1.3%. [2][3][4] Studies have shown an association between CD and numerous autoimmune and rheumatic conditions including rheumatoid arthritis, 5,6 juvenile idiopathic arthritis (JIA), [7][8][9][10] autoimmune thyroiditis, [10][11][12] autoimmune thrombocytopenic purpura, hemolytic anemia, 6 vasculitis, 5,6 polymyositis and dermatomyositis, 13,14 systemic lupus erythematosus (SLE), 5,6,15,16 scleroderma, 5,6 mixed connective tissue disease, 5 diabetes mellitus, [17][18][19][20][21][22] Sjögren syndrome, 6,10,23,24 and dermatitis herpetiformis. 24 Among the connective tissue disorders, only Sjögren syndrome appears to share the HLA DQ2/DQ8 haplotype with CD.…”

Section: What This Study Addsmentioning

confidence: 99%

Unrecognized Celiac Disease in Children Presenting for Rheumatology Evaluation

et al. 2015

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BACKGROUND AND OBJECTIVES: Current clinical guidelines do not consider patients with rheumatic conditions to be at high risk for celiac disease (CD) despite numerous reported associations between the two in adults and children. The objective of this study was to evaluate the prevalence of CD among patients presenting for pediatric rheumatology evaluation.METHODS: A total of 2125 patients presenting for initial evaluation by the Division of Pediatric Rheumatology at the Hospital for Special Surgery between June 2006 and December 2013 were screened for CD as a part of the standard initial serologic evaluation. The charts of these patients were evaluated retrospectively at the end of this period.RESULTS: 36 patients (30 girls, 6 boys, mean age 9.4 6 4.3 years, range 2-16 years) received a diagnosis of CD after serologic testing and evaluation by pediatric gastroenterology. Eight additional patients with known diagnoses of CD presented during this time period. The total prevalence of CD over this 6.5-year period was 2.0%. The most common presenting complaints among patients diagnosed with CD were myalgias, arthralgias, and rash. Less frequently, patients reported gastrointestinal complaints including abdominal pain, nausea, and diarrhea. All patients reported improvement or complete resolution of their musculoskeletal symptoms after initiation of a gluten-free diet.CONCLUSIONS: This study identified 36 new cases of CD among children presenting for rheumatology evaluation, for an overall prevalence rate of 2.0%. The majority of patients who ultimately received a diagnosis of CD presented with extraintestinal manifestations. These results underscore the importance of screening children presenting for rheumatology evaluation for CD. WHAT'S KNOWN ON THIS SUBJECT:Associations have been reported between celiac disease (CD) and numerous autoimmune conditions in adults and children. However, current screening guidelines do not consider patients with rheumatic diseases to be at high risk for CD. WHAT THIS STUDY ADDS:The prevalence of CD in children presenting for rheumatology evaluation was found to be 2% by routine serologic screening. The majority of screening-detected CD cases had no CD-associated symptoms. Gluten restriction was found to relieve some musculoskeletal complaints.

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“…There is strong evidence for the association between Type 1 diabetes and CD. [8][9][10][11][12][13][14][15][16][17][18][19] Up to 8% of patients with Type 1 diabetes have the characteristic features of CD on small intestinal biopsy.…”

Section: Introductionmentioning

confidence: 99%

Celiac disease and pregnancy in Indian scenario

Verma

Tyagi

Singh

2018

Int J Reprod Contracept Obstet Gynecol

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Celiac disease is a chronic lifelong inflammatory condition of gastrointestinal tract specifically the small intestine. We report a case of pregnancy outcome in a patient with celiac disease (gluten sensitive enteropathy) diagnosed during the investigations of recurrent abortions and intermittent diarrhoea since childhood. A 32 years old patient who had four abortions and loss of a premature baby was diagnosed as celiac disease during investigations of recurrent abortions and diarrhoea since childhood. After stabilisation of disease she conceived spontaneously. Patient had regular follow up in some private institute. She was referred to our hospital as a case of IUGR with color Doppler changes with breech presentation with sluggish fetal movements at 37 weeks and emergency caesarean section was performed. A male fetus with 2.25 kg AS 7, 9 at birth was delivered. The cause of her recurrent pregnancy losses and previous preterm birth was celiac disease. Celiac disease (CD) is an immune-mediated enteropathy caused by a permanent sensitivity to gluten in genetically susceptible individual. It may also lead to serious maternal and fetal complications because of systemic effects of disease however a successful pregnancy outcome is possible when pre-gestational diagnosis is made and proper management of disease during pregnancy is achieved.

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Prevalence of coeliac disease in diabetic children and adolescents

Cited by 88 publications

References 30 publications

A Longitudinal Study of the Effects of a Gluten-Free Diet on Glycemic Control and Weight Gain in Subjects With Type 1 Diabetes and Celiac Disease

A Longitudinal Study of the Effects of a Gluten-Free Diet on Glycemic Control and Weight Gain in Subjects With Type 1 Diabetes and Celiac Disease

Unrecognized Celiac Disease in Children Presenting for Rheumatology Evaluation

Celiac disease and pregnancy in Indian scenario

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