Prevalence of co-morbidities in severe asthma, COPD and overlap syndrome

Hekking, Pieter Paul; Amelink, Marijke; Wener, Reinier; Bouvy, Marcel L.; Bel, Elisabeth H.

doi:10.1183/13993003.congress-2015.pa1045

Cited by 2 publications

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“…The result of this previous study support our finding. In an European report, the frequency of the anxity/depression in the patients receiving the ICSs/OSs with the ACOS cohort (n = 703; 34.3%) is nearly the same as in the COPD cohort (n = 519,35.8%) [ 34 ] in line with these findings.…”

Section: Discussionsupporting

confidence: 61%

The relationship of depression in asthma–chronic obstructive pulmonary disease overlap syndrome

Yeh¹,

Lin²,

Hsu³

et al. 2017

PLoS ONE

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PurposeTo clarify the relationship between asthma–chronic obstructive pulmonary disease overlap syndrome (ACOS) and depression.MethodsWe identified 10,911 patients who received an ACOS diagnosis and concurrent treatment between January 2000 and December 2009. Subjects without ACOS were included in the non-ACOS cohort (n = 10,911). Cox proportional hazard regression analysis was performed to compare the risk of depression between the ACOS and non-ACOS cohorts.ResultsThe risk of depression was higher in the ACOS cohort than in the non-ACOS cohort (adjusted hazard ratios (aHRs) = 1.67, 95% confidence interval [CI] = 1.48–1.88). In the ACOS cohort, the aHRs for depression were [2.44 (95% CI = 1.45–4.11); 2.36 (95% CI = 1.58–3.52)] in patients [aged 20–39 years; without comorbidity]. In the ACOS cohort, the aHRs for depression were 1.70 (95% CI = 1.51–1.93) and 1.84 (95% CI = 1.55–2.19) in patients without inhaled corticosteroids (ICSs) and oral steroids (OSs) use, respectively. Moreover, the aHRs for the risk of depression were 1.16 (95% CI = 0.95–1.41) and 1.12 (95% CI = 0.96–1.29) in patients with ICSs and OSs use, respectively.ConclusionThe risk of depression is higher in ACOS patients, even in those without comorbidities or in young adults. The events of the depression were not significant difference in patients receiving the ICSs/OSs between the ACOS and the non-ACOS cohorts.

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Section: Discussionsupporting

confidence: 61%

The relationship of depression in asthma–chronic obstructive pulmonary disease overlap syndrome

Yeh¹,

Lin²,

Hsu³

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…These findings are consistent with those of a retrospective cohort study conducted by van Boven et al , who reported a strong association of CVDs with hospitalisation for ACOS, 28 and those of a study conducted by Hekking et al , who discovered that prescriptions for CVDs were the most prevalent in patients with ACOS. 29 We also found that even patients without comorbidities in the ACOS cohort were associated with a significantly higher risk of CVDs during the follow-up period (aHRs for CAD, CD and HF=1.82, 1.80 and 2.31, respectively; all p<0.001).…”

Section: Discussionsupporting

confidence: 55%

Association of asthma–chronic obstructive pulmonary disease overlap syndrome with coronary artery disease, cardiac dysrhythmia and heart failure: a population-based retrospective cohort study

et al. 2017

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ObjectivesPatients with asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) and cardiovascular diseases (CVDs) share common risk factors. However, the association between ACOS and the incidence of CVDs has not been reported. This study investigated the relationship between CVDs and ACOS in the general population.SettingData were obtained from Taiwan’s National Health Insurance Research Database for the period 2000 to 2010.ParticipantsThe ACOS cohort comprised patients (n=5814) who had received a diagnosis of asthma and COPD. The non-ACOS cohort comprised patients who had not received a diagnosis of asthma or COPD and were matched to the ACOS cohort (2:1) by age, sex and index date (n=11 625).Primary and secondary outcome measuresThe cumulative incidence of CVDs—coronary artery disease (CAD), cardiac dysrhythmia (CD) and heart failure (HF)—was calculated. Cox proportional regression analysis was employed to examine the relationship between ACOS and CVDs.ResultsAfter adjustment for multiple confounding factors—age, sex, comorbidities and medications—patients with ACOS were associated with a significantly higher risk of CVDs; the adjusted HRs (aHRs; 95% CI) for CAD, CD and HF were 1.62 (1.50 to 1.76), 1.44 (1.30 to 1.61) and 1.94 (1.73 to 2.19), respectively, whereas those of beta-blockers treatment for CAD, CD and HF were 1.19 (0.92 to 1.53), 0.90 (0.56 to 1.45) and 0.82 (0.49 to 1.38). The aHR of atenolol treatment for CD was 1.72 (1.01 to 2.93). The aHRs (95% CIs) of ACOS without acute exacerbation of COPD (AE-COPD) for CAD, CD and HF were 1.85 (1.70 to 2.01), 1.57 (1.40 to 1.77) and 2.07 (1.82 to 2.35), respectively.ConclusionACOS was associated with higher CVD risk, even without the presence of previous comorbidities or AE-COPD. No significant differences in CVD events were observed in the ACOS cohort using beta-blockers, except for those using atenolol for treating CD.

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Prevalence of co-morbidities in severe asthma, COPD and overlap syndrome

Cited by 2 publications

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The relationship of depression in asthma–chronic obstructive pulmonary disease overlap syndrome

The relationship of depression in asthma–chronic obstructive pulmonary disease overlap syndrome

Association of asthma–chronic obstructive pulmonary disease overlap syndrome with coronary artery disease, cardiac dysrhythmia and heart failure: a population-based retrospective cohort study

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