Prevalence of clinically relevant oral mucositis in outpatients receiving myelosuppressive chemotherapy for solid tumors

Wuketich, S; Hienz, Stefan A.; Marosi, Christine

doi:10.1007/s00520-011-1107-y

Cited by 44 publications

(45 citation statements)

References 28 publications

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“…1 Studies on oral mucositis (OM). Incidence of OM was investigated in patients with hematopoietic stem cell transplantation (HSCT) in 14 studies (32.6%) [3,5,14,17,19,28,31,36,37,39,44,56,62,67], in head and neck cancer (HNC) patients in 13 studies (30.2%) [18,21,29,40,50,51,55,59,60,61,63,70,73], in patients with chemotherapy in 13 studies (30.2%) [15,16,22,23,24,25,30,34,38,46,48,58,71], with mixed tumor types and treatment in 1 study (2.3%) [13] and with palliative care in 2 studies (4.7%) [32,57]. Cost related to OM in patients undergoing HSCT was the focus in 4 studies [7,14,17,54], in HNC patients in 2 studies [43,47], in patients with chemotherapy in 6 studies [9,10,11,12,42,49,68], and in patients with mixed tumor types and treatment in 2 studies [20,45].…”

Section: Resultsmentioning

confidence: 99%

“…In patients with chemotherapy for solid tumors, OM frequency for all grades is reported to be between 14.4% and 81.3% depending on the type of tumor and treatment, with a preponderance of mild OM (grade < 3), and a frequency of severe OM (grade ≥ 3) generally below 5% [15,16,24,30,34,38,58]. In a study on patients with advanced cancer, overall prevalence of OM was 22.3% [32].…”

Section: Resultsmentioning

confidence: 99%

“…There were 7 studies covering 2 topics each [3,13,14,15,16,17,18] and 7 meta-analyses [19,20,21,22,23,24,25]. 20 studies (29.4%) were from Europe [3,5,9,10,11,12,15,22,26,27,28,29,30,31,32,33,34,35,36,37,38,] 20 from the US [4,14,17,19,20,24,39,40,41,42,43,44,45,46,47,48,49,50,51,52], 3 studies (4.4%) from US plus Europe [23,53,54], 6 studies (8.8%) from Japan [16,55,56,57,58,59], 6 studies (8.8%) from China [18,25,60,61,62,63], 2 studies (3.0%) from Hong Kong [13,64,65], 3 studies (4.4%) from Canada [66,67,68], 3 studies (4.4%) from India [21,69,70] and 5 studies (7.4%) from other countries [7,71,72,73,74]. 21 studies (30.9%) used the National Cancer Institute - Common Terminology Criteria for Adverse Events (NCI-CTCAE) scale for assessment of OM.…”

Section: Resultsmentioning

confidence: 99%

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Burden of Oral Mucositis: A Systematic Review and Implications for Future Research

et al. 2018

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Background: Surprisingly little is known about the burden of oral mucositis (OM). We provide a systematic review of studies on the burden of OM (incidence, economic impact, health-related quality of life (HRQoL)). Methods: Systematic literature searches were made in BIOSIS, EMBASE, and MEDLINE. Inclusion criteria were studies on OM in hematology/oncology patients of ≥ 18 years, journal articles, English language, and published between 2000 and 2016; OM treatment studies were excluded. Quality assessment was performed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Results: We screened 4,996 hits, and identified 68 studies of which 13 were without transparency on OM grading. The evidence level of 65 studies was rated ‘low' or ‘very low' in 58.5%, ‘moderate' in 20% and ‘high' in 21.5%. Mean value of incidence (7 studies) was 83.5% for all grades of OM with hematopoietic stem cell transplantation. OM incidence for all grades in head and neck cancer patients was 59.4-100%. Considering the economic impact, 16 studies showed highly variable numbers. HRQoL was measured in 16 studies using 13 different instruments. Statistically significant changes in HRQoL scores were demonstrated. Conclusion: OM is common, burdensome, costly and imposes major reductions in HRQoL. However, from a quality standpoint, the level of current evidence in OM is disappointing. The field needs continued attention to address methodological challenges.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Burden of Oral Mucositis: A Systematic Review and Implications for Future Research

et al. 2018

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“…Repetitive treatment cycles are associated with an increasing risk and severity of mucositis [58]. Even when clinical mucositis scores are low, even the modest degrees of mucositis still represent potentially important breakdowns in the host innate defense barriers [59]. …”

Section: Introductionmentioning

confidence: 99%

Bacterial Pneumonia in Patients with Cancer

Wong¹,

Evans

2017

Clinics in Chest Medicine

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Synopsis Bacterial pneumonias exact unacceptable morbidity upon patients with cancer. While the risk is often most pronounced amongst patients with treatment-induced cytopenias, the numerous contributors to life-threatening pneumonias in cancer populations range from derangements of lung architecture and swallow function to complex immune defects associated with cytotoxic therapies and graft-vs.-host disease. These structural and immunologic abnormalities often make the diagnosis of pneumonia challenging in cancer patients and impact the composition and duration of therapy. This manuscript addresses the host factors that contribute to pneumonia susceptibility, summarizes diagnostic recommendations, and reviews current guidelines for management of bacterial pneumonia in cancer patients.

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“…The reason is that salt water is not only a natural disinfectant but it also removes any swelling from the tissue. Giving a mouth wash to the patients with a medicinal property like those of turmeric or normal saline can prove very economical and beneficial for the patient in terms of cure and relieve from symptoms and also in regards to its use in the future and preventing complications [21][22][23][24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study to Assess the Effectiveness of Turmeric Mouth Wash versus Saline Mouth Wash on Treatment Induced Oral Mucositis (Tiom) in a Selected Hospital at Mangalore

Saldanha¹,

Almeida²

2014

J Clinic Res Bioeth

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Oral mucositis is the most common, debilitating complication of cancer treatments. Chemotherapy and/or radiation therapy will interfere with the normal turnover of epithelial, cells leading to mucosal injury. The care of these patients includes the regular use of an effective mouth wash periodically. The active ingredient in turmeric is curcumin which protects healthy cells from harmful effects of radiation and chemotherapy. Salt mouthwash can soothe the pain and keep food particles clear so as to avoid infection. The study made use of a two group pre-test post-test time series design to determine the effectiveness of Turmeric and Saline mouth wash on TIOM. A purposive random sampling was used and mouth wash was given three times daily for 5 days. The oral mucosa of the patients was assessed using an Oral Mucositis assessment checklist and pain using pain scale every morning before the intervention and evening after the intervention. There was a significant difference in the score of TIOM between pre-intervention on Day 1 morning and post intervention score on day 5 evening in turmeric and saline group but on comparison it was found that turmeric mouth wash was effective than saline mouth in all the days except in Day 3 where there was no significant difference found. Both the mouth wash were individually effective but on comparison turmeric mouth wash was better than saline mouth wash.

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Prevalence of clinically relevant oral mucositis in outpatients receiving myelosuppressive chemotherapy for solid tumors

Cited by 44 publications

References 28 publications

Burden of Oral Mucositis: A Systematic Review and Implications for Future Research

Burden of Oral Mucositis: A Systematic Review and Implications for Future Research

Bacterial Pneumonia in Patients with Cancer

A Comparative Study to Assess the Effectiveness of Turmeric Mouth Wash versus Saline Mouth Wash on Treatment Induced Oral Mucositis (Tiom) in a Selected Hospital at Mangalore

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