Prevalence of clinical thiamine deficiency in individuals with medically complicated obesity

Nath, Anand; Tran, Tung Thanh; Shope, Timothy; Koch, Timothy R.

doi:10.1016/j.nutres.2016.11.012

Cited by 32 publications

(23 citation statements)

References 38 publications

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“…The current reference ranges may not be valid in a post-stroke patient cohort, and the authors agree with the proposal that current reference data for thiamine deficiency should be called into question as they may not accurately describe VitB1 inadequacy in a pathological state as they were based on normalized values in healthy populations [27]. Given the increasing literature describing the importance of VitB1 in brain function among not only patients suffering from alcoholism [28,29] but also the geriatric population suffering from cognitive deficits [30], critically ill patients [17,31,32], post-bariatric procedures [33], and those suffering from conditions such as Alzhemers [34], HIV/AIDS [35], malignancy [36], diabetes [37], and obesity [5,38], it is important to consider the potential role of low and low normal levels of VitB1 in the population recovering from acute stroke.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Low Plasma Vitamin B1 in the Stroke Population Admitted to Acute Inpatient Rehabilitation

et al. 2020

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Objective: To determine the prevalence of vitamin B1 (VitB1) deficiency in the stroke population admitted to acute inpatient rehabilitation. Design: Retrospective cohort study. Setting: Acute inpatient rehabilitation facility at an academic medical center. Participants: 119 consecutive stroke patients admitted to stroke service from 1 January 2018 to 31 December 2018. Interventions: Not applicable. Main Outcome Measures: Plasma VitB1 level. Results: There were 17 patients (14%; 95% CI 9–22%) with low VitB1 with a range of 2–3 nmol/L, an additional 58 (49%; CI 40–58%) patients had normal low VitB1 with a range of 4–9 nmol/L, twenty-five patients (21%; CI 15–29%) had normal high VitB1 with a range of 10–15 nmol/L, and nineteen patients (16%; CI 10–24%) had high VitB1 with a range of 16–43 nmol/L. Conclusions: In this cohort of patients admitted to the stroke service at an acute rehabilitation facility, there is evidence of thiamine deficiency. Moreover, the data suggest that there is inadequate acute intake of VitB1. Given the role of thiamine deficiency in neurologic function, further study of the role of thiamine optimization in the acute stroke rehabilitation population is warranted.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Low Plasma Vitamin B1 in the Stroke Population Admitted to Acute Inpatient Rehabilitation

et al. 2020

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“…Whether attention to thiamine status may be required in MR programs is conjectural; the relevance of this change may not have clinical implications as participants’ thiamine status remained within the normal range. However, clinical thiamine deficiency has been shown to be common in individuals with medically complicated obesity and in pre-operative obesity surgery patients [ 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Randomized Trial of a High Protein, Partial Meal Replacement Program with or without Alternate Day Fasting: Similar Effects on Weight Loss, Retention Status, Nutritional, Metabolic, and Behavioral Outcomes

et al. 2018

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Higher-protein diets, meal replacements, and greater early weight loss have separately been associated with greater weight loss. We compared a high-protein, meal replacement program with daily energy restriction (DER) to one which provided greater energy restriction adding alternate day fasting (ADF + DER; alternating days of modified-fasting and DER plus 1 ad libitum day/week) on retention, weight loss, physiological, nutritional, and behavioral markers. Participants were randomized to ADF + DER or DER for 16 weeks (n = 162, age 40 ± 8 years BMI 36 ± 6 kg/m2 (Mean ± SD)) plus 8 weeks weight maintenance. At week 16 weight change was −10.7 ± 0.5 kg and −11.2 ± 0.6 kg in ADF + DER and DER groups (treatment NS). Fat mass, visceral adipose tissue, and lean mass (p < 0.05) were similarly reduced between treatments. Weight loss was sustained to 24 weeks (treatment NS). Fasting LDL-cholesterol, triglycerides, insulin, hsCRP, glucose, and blood pressure all improved (p < 0.05; treatment NS). Transferrin saturation, ferritin, serum zinc, folate, and B12 improved (p < 0.05; treatment NS). Plasma thiamine and vitamin D levels decreased, reflecting lower carbohydrate intakes and seasonal changes, respectively. Food cravings, quality of life, and mood improved (treatment NS). Energy, fatigue, and pain improved slightly more in DER (p < 0.05). This study supports the use of higher protein, meal replacement programs with or without ADF in weight management.

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“…Thiaminase is also thermolabile, and the act of cooking these foods considerably reduces the risk of thiamin deficiency . In addition, ingestion of beverages such as coffee, tea, and other beverages rich in tannins also contributes to thiamin deficiency . On the other hand, ingestion of juices from citrus fruits increases the bioavailability of thiamin because of their citric acid and ascorbic acid content…”

Section: Thiamin: Function and Sourcesmentioning

confidence: 99%

“…In addition, obesity alone can increase risk of thiamin deficiency. In general, these patients consume a diet poor in vegetables and rich in simple sugars and processed foods, which is a low source of thiamin …”

Section: Risk Factors For Thiamin Deficiencymentioning

confidence: 99%

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Role of Thiamin in Health and Disease

et al. 2019

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Thiamin is a hydrosoluble vitamin that plays a role in several biological processes, mainly in glucose metabolism. There are several risk factors for developing thiamin deficiency, such as malnutrition, refeeding syndrome, gastrointestinal surgery, and alcoholism. Recently, the role of thiamin in critically ill patients has gained prominence, and the prevalence of thiamin deficiency was found to be increased in patients with severe burns, major surgery, septic shock, end-stage renal disease, and heart failure. In adults, thiamin deficiency presents as encephalopathy, dry beriberi (with neurological signs and symptoms), or wet beriberi (with cardiovascular signs and symptoms). Thiamin deficiency can be diagnosed clinically, and all clinicians should be aware of this disease, especially in patients with risk factors for thiamin deficiency. Thiamin supplementation should be started as early as possible in patients suspected to have thiamin deficiency. Treatment is safe, inexpensive, simple, and life-saving. Diagnosis is confirmed on a positive response to treatment. (Nutr Clin Pract. 2019;34:558-564)

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Prevalence of clinical thiamine deficiency in individuals with medically complicated obesity

Cited by 32 publications

References 38 publications

Prevalence of Low Plasma Vitamin B1 in the Stroke Population Admitted to Acute Inpatient Rehabilitation

Prevalence of Low Plasma Vitamin B1 in the Stroke Population Admitted to Acute Inpatient Rehabilitation

Randomized Trial of a High Protein, Partial Meal Replacement Program with or without Alternate Day Fasting: Similar Effects on Weight Loss, Retention Status, Nutritional, Metabolic, and Behavioral Outcomes

Role of Thiamin in Health and Disease

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