Prevalence of clinical and radiological osteoarthritis in knee, hip, and hand in an urban adult population of Mexico City

Macías‐Hernández, Salvador Israel; Zepeda-Borbón, Erick Rodrigo; Lara-Vázquez, Blanca Isabel; Cuevas-Quintero, Nuria María; Morones-Alba, Juan Daniel; Cruz‐Medina, Eva; Nava‐Bringas, Tania Inés; Miranda‐Duarte, Antonio

doi:10.1016/j.reuma.2018.06.001

Cited by 13 publications

(22 citation statements)

References 24 publications

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“…OA currently represents an important cause of disability [4], with an estimated prevalence ranging from 1 to 10% in the general population [5][6][7][8]. It is more common in female subjects [9] and in the elderly [10,11].…”

Section: Introductionmentioning

confidence: 99%

Fascia Lata Alterations in Hip Osteoarthritis: An Observational Cross-Sectional Study

Fantoni

Biz

Fan

et al. 2021

Life

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The present study compares the structure and composition of fascia lata in healthy subjects and in patients with hip osteoarthritis (OA), to evaluate any differences in the amount of Collagen type I, Collagen type III, and Hyaluronan. Fascia lata samples from voluntary healthy subjects and patients with OA were harvested during surgery. Collagen type I (COL I), III (COL III) antibody, and biotinylated hyaluronan binding protein (HABP) immunohistochemistry stainings were used to evaluate fascial morphology and COL I, COL III, and Hyaluronan (HA) content in both groups. Ten samples from healthy subjects and 11 samples from OA patients were collected. COL I was significantly more abundant in the OA group (p = 0.0015), with a median percentage positivity of 75.2 (IQR 13.11)%, while representing only 67 (IQR: 8.71)% in control cases. COL III, with median values of 9.5 (IQR 3.63)% (OA group) and 17.10 (IQR 11)% (control cases), respectively, showed significant reduction in OA patients (p = 0.002). HA showed a median value of 10.01 (IQR 8.11)% in OA patients, denoting significant decrease (p < 0.0001) with respect to the control group median 39.31 (IQR 5.62)%. The observed differences suggest a relationship between fascial pathology and hip OA. The observed increase in COL I in OA patients, along with the reduction of COL III and HA, could lead to fascial stiffening, which could alter fascial mechanics and be linked to the development and symptoms of OA.

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Section: Introductionmentioning

confidence: 99%

Fascia Lata Alterations in Hip Osteoarthritis: An Observational Cross-Sectional Study

Fantoni

Biz

Fan

et al. 2021

Life

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“…Among those ≥ 40 years of age in Mexico, the total prevalence of symptomatic knee OA was 19.6% [18]. Prevalence was significantly higher in women compared with men [13,14,18]. The total prevalence of grade ≥ 2 radiographic knee OA was 22% among those ≥ 39 years of age in a Brazilian study [19] and 25.5% among those ≥ 40 years of age in a Mexican study [18] (Table 3).…”

Section: Resultsmentioning

confidence: 97%

“…1). Of these, 13 publications reported studies of populations from the Latin American region [10][11][12][13][14][15][16][17][18][19][20][21][22], with over 60% of studies from Mexico [11,[16][17][18]22] and Ecuador [13][14][15] (Fig. 2).…”

Section: Resultsmentioning

confidence: 99%

“…All of the 13 studies [10][11][12][13][14][15][16][17][18][19][20][21][22] reported knee OA and 5 (38%) studies The overall prevalence of physician-diagnosed symptomatic knee OA among men and women ≥ 18 years of age (Table 2) ranged from 1.55% in the Peruvian population [21] to 7.4% in Ecuador [14]. Among those ≥ 40 years of age in Mexico, the total prevalence of symptomatic knee OA was 19.6% [18]. Prevalence was significantly higher in women compared with men [13,14,18].…”

Section: Resultsmentioning

confidence: 99%

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Assessing the burden of osteoarthritis in Latin America: a rapid evidence assessment

et al. 2022

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This rapid evidence assessment (REA) was conducted to explore the burden of weight-bearing joint osteoarthritis in the developing countries of Latin America. REA methodology used a standardized search strategy to identify observational studies published from 2010 to 23 April 2020 that reported outcomes pertaining to the epidemiology and humanistic or economic burden of weight-bearing osteoarthritis. Relevant data from each included study were used to populate bespoke data extraction tables and qualitatively analyzed. Thirteen publications were identified that reported on knee and hip osteoarthritis in the Latin American region. Overall prevalence of physician-diagnosed symptomatic knee osteoarthritis in adults ranged from 1.55% in Peru to 7.4% in Ecuador. Total prevalence of grade ≥ 2 radiographic knee osteoarthritis was 22% among those ≥ 39 years of age in Brazil and 25.5% among those ≥ 40 years of age in Mexico. The prevalence of symptomatic/radiographic knee osteoarthritis was 7.1% in people ≥ 18 years of age in Mexico and 17.6% among those ≥ 40 years of age. Prevalence of hip osteoarthritis was similar to or slightly lower than knee osteoarthritis. The limited data available indicates weight-bearing osteoarthritis negatively affects quality of life and that the economic burden may vary between countries with different healthcare systems. The limited evidence found in the published literature suggests the burden of osteoarthritis in Latin America is substantial. Our analysis identified several evidence gaps, particularly for health-related quality of life and socioeconomic outcomes. Further research is of particular importance in areas where government-subsidized healthcare and resources are scarce.

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“…The prevalence of knee osteoarthritis (KOA) worldwide is *3.8% (Cross et al, 2014), affecting more than 200 million people (Collaborators., 2016). In Mexico, the prevalence of KOA was estimated at 17.6% (Macias-Hernandez et al, 2018). Some studies have shown that the role of the genetic component in the risk of OA ranges from 40% to 80% (Su et al, 2015;Van Meurs, 2017).…”

Section: Introductionmentioning

confidence: 99%

Analyses of the Genetic Polymorphisms rs3740199 and rs1871054 of the ADAM12 Gene and the Alleles at the rs2073508 Loci of the TGFB1 Gene and Their Contribution to Susceptibility to Primary Knee Osteoarthritis

Muñiz

Galarza

Astorga

et al. 2020

Genetic Testing and Molecular Biomarkers

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To analyze the association of polymorphisms in the ADAM12 (rs3740199 and rs1871054) and TGFB1 (rs2073508) genes with knee osteoarthritis (KOA) in a population from northern Mexico. Methods: A total of 296 individuals were included in the study. Primary KOA was confirmed according to the criteria established by the American College of Rheumatology. A real-time PCR-based DNA genotyping method was used to evaluate the rs3740199, rs1871054, and rs2073508 polymorphisms in 132 cases and 164 controls. Results: Our results demonstrate that the ADAM12 rs3740199 polymorphism was significantly associated with primary KOA under the recessive model ( p = 0.036). However, after performing a multinomial logistic regression model, no significant association was found ( p = 0.722). Furthermore, no associations for the rs1871054 and rs2073508 polymorphisms were observed in this study. Conclusion: These findings suggest that polymorphisms within the ADAM12 and TGFB1 genes may not have a significant influence on primary KOA susceptibility in the Mexican Mestizo population; however, inclusion of other ethnic groups and a larger sample size are needed to more fully analyze the role of these polymorphisms with KOA risk.

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Prevalence of clinical and radiological osteoarthritis in knee, hip, and hand in an urban adult population of Mexico City

Cited by 13 publications

References 24 publications

Fascia Lata Alterations in Hip Osteoarthritis: An Observational Cross-Sectional Study

Fascia Lata Alterations in Hip Osteoarthritis: An Observational Cross-Sectional Study

Assessing the burden of osteoarthritis in Latin America: a rapid evidence assessment

Analyses of the Genetic Polymorphisms rs3740199 and rs1871054 of the ADAM12 Gene and the Alleles at the rs2073508 Loci of the TGFB1 Gene and Their Contribution to Susceptibility to Primary Knee Osteoarthritis

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