Prevalence of clinical and radiographic signs of osteoarthrosis of the temporomandibular joint in an older persons community

Schmitter, Marc; Essig, Marco; Seneadza, Viktoria; Balke, Z.; Schröder, Johannes; Rammelsberg, Peter

doi:10.1259/dmfr/16270943

Cited by 75 publications

(61 citation statements)

References 14 publications

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“…21 Several studies reveal that there is a poor correlation between condylar changes (as observed on CBCT or magnetic resonance imaging), pain and other clinical signs and symptoms of TMJ osteoarthitis. 22,23 In standard practice, orthodontic and orthognathic treatment can be started after craniofacial growth has ceased, which accounts for the mean age in the Class II and Class III groups, with which the Class I subjects were matched. The relatively young age of the patients is a factor that must be taken into consideration when analysing and comparing the results.…”

Section: Discussionmentioning

confidence: 99%

The prevalence of TMJ osteoarthritis in asymptomatic patients with dentofacial deformities: a cone-beam CT study

Krisjane

Urtane

Krumina

et al. 2012

International Journal of Oral and Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 99%

The prevalence of TMJ osteoarthritis in asymptomatic patients with dentofacial deformities: a cone-beam CT study

Krisjane

Urtane

Krumina

et al. 2012

International Journal of Oral and Maxillofacial Surgery

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“…The assumption that OA might be the primary cause of pain cannot be supported by our study, in line with previous studies on the relationship between TMJ pain and anatomic changes in the TMJ 33 and on OA in elderly people, in whom joints exhibiting OA were largely asymptomatic. 34 In the absence of abnormalities on MRI, such as anterior disc displacement, joint effusion, condylar fractures or neoplasms, TMJ pain can be connected with an altered disc position in the MRI oblique coronal plane. In painful TMJs, the disc appears to be reduced in its transverse dimensions and less medially located than in healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

Temporomandibular joint (TMJ) disc position in patients with TMJ pain assessed by coronal MRI

Eberhard¹,

Giannakopoulos²,

Rohde³

et al. 2013

Dentomaxillofacial Radiology

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Objectives: To assess the position of the temporomandibular joint (TMJ) disc in patients with TMJ pain and compare it with equivalent published data of asymptomatic volunteers. Methods: The oblique coronal closed-and open-jaw MR images from 66 patients with TMJ pain were evaluated. Clinical examination followed the research diagnostic criteria for temporomandibular disorders. In all coronal images, the transverse condylar axis and the medial and lateral edges of the disc were determined using special software. Inter-rater agreement was calculated [two raters; inter-rater correlation coefficient (ICC)]. The presence of osteoarthrosis (OA) was determined by two independent raters. The influence of OA was estimated in patients (generalized estimation equation model). The results were compared with those of healthy volunteers (t-test). Differences between closed and open jaw in patients were analysed with the Wilcoxon matched-pair test. Results: The ICC was good for the transverse condylar axis (0.987) and the medial edge of the disc (0.799) and fair for the lateral edge (0.355). On average, the disc projected 5.5% to the medial side; laterally, the condyle was partially uncovered by the disc (216.6%). In the openjaw position, both the medial and the lateral edges shifted medially (to 17.6% vs 223.6%, Wilcoxon matched-pair test, p , 0.001). OA had no significant influence (generalized estimation equation model, p 5 0.952). The disc position differed significantly from asymptomatic individuals (t-test, p , 0.001) who showed a medial disc position and full coverage of the condyle. Conclusions: In patients with TMJ pain, the disc seems to be smaller and located less medially than in healthy volunteers. The extent of the medial shift on opening was similar.

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“…It is believed that there are a finite number of mandibular condylar cartilage progenitor cells; once the cells are depleted, repair remodeling and growth diminish in capacity. Like other joints, the TMJ degenerates with age 4, 5 . However, women between the ages of 44–55 years are most likely to seek treatment 6, 7 , suggesting a role for estrogen in the disease process.…”

Section: Introductionmentioning

confidence: 99%

Estrogen via estrogen receptor beta partially inhibits mandibular condylar cartilage growth

Chen

Kamiya

Polur

et al. 2014

Osteoarthritis and Cartilage

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Objective Temporomandibular joint diseases predominantly afflict women, suggesting a role for female hormones in the disease process. However, little is known about the role of estrogen receptor (ER) signaling in regulating mandibular condylar cartilage growth. Therefore, the goal of this study was to examine the effects of altered estrogen levels on the mandibular condylar cartilage in WT and ER beta KO mice. Materials and Methods 21-day-old female WT (n=37) and ER beta KO mice (n=36) were either sham operated or ovariectomized, and treated with either placebo or estradiol. The mandibular condylar cartilage was evaluated by histomorphometry, proliferation was analyzed by double EdU/BrdU labeling, and assays on gene and protein expression of chondrocyte maturation markers were performed. Results In WT mice, ovariectomy caused a significant increase in mandibular condylar cartilage cell numbers, a significant increase in Sox9 expression and a significant increase in proliferation compared with sham operated WT mice. In contrast, ovariectomy did not cause any of these effects in the ER beta KO mice. Estrogen replacement treatment in ovariectomized WT mice caused a significant decrease in ER alpha expression and a significant increase in Sost expression compared with ovariectomized mice treated with placebo. Estrogen replacement treatment in ovariectomized ER beta KO mice caused a significant increase in Col2 expression, no change in ER alpha expression, and a significant increase in Sost expression. Conclusion Estrogen via ER beta inhibits proliferation and ER alpha expression while estrogen independent of ER beta induces Col2 and Sost expression.

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Prevalence of clinical and radiographic signs of osteoarthrosis of the temporomandibular joint in an older persons community

Cited by 75 publications

References 14 publications

The prevalence of TMJ osteoarthritis in asymptomatic patients with dentofacial deformities: a cone-beam CT study

The prevalence of TMJ osteoarthritis in asymptomatic patients with dentofacial deformities: a cone-beam CT study

Temporomandibular joint (TMJ) disc position in patients with TMJ pain assessed by coronal MRI

Estrogen via estrogen receptor beta partially inhibits mandibular condylar cartilage growth

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