Prevalence of cleft lip and palate and associated factors in Brazil's Midwest: a single-center study

Errari-Piloni, Carolina; Barros, Leandro Almeida Nascimento; Jesuino, Flávia Aline Silva; Valladares‐Neto, José

doi:10.1590/1807-3107bor-2021.vol35.0039

Cited by 5 publications

(8 citation statements)

References 26 publications

(40 reference statements)

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“…It is important to highlight that until the writing of this article only two studies [ 14 , 15 ] have identified possible factors associated with the development of NSCP typesHowever, unlike another Brazilian study [ 15 ], complete NSCP was more prevalent in our study.…”

Section: Discussionmentioning

confidence: 53%

“…Studies have attempted to understand the differences in cleft subtypes in relation to social, demographics and gestational history variables [ 4 , 14 , 15 ]. We found that individuals whose mothers reported having had medical problems during pregnancy (35.1%) were 1.94 more likely to have incomplete NSCP ( p = 0.016).…”

Section: Discussionmentioning

confidence: 99%

“…Evidence about medical problems in pregnancy with the development of NSCP still needs to be well evaluated. Studies in Brazil showed a rate of 21.3% [ 15 ] and 76.4% [ 24 ] of NSCP children of pregnancies with medical problems, however the subtype of NSCP was not considered.…”

Section: Discussionmentioning

confidence: 99%

“…This finding is higher than the 3.0% prevalence in Spain [ 21 ] and 6.8% in Brazil [ 17 ]. Although, in study realized in another region in Brazil, the prevalence of NSOC family history was 33.2% NSCP individuals [ 15 ]. It is believed that the results may have been influenced by the sample sizes of their respective studies.…”

Section: Discussionmentioning

confidence: 99%

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Isolated nonsyndromic cleft palate: multicenter epidemiological study in the Brazil

et al. 2023

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Background Nonsyndromic orofacial clefts (NSOC) are the craniofacial most common congenital malformations. There are evidences that the nonsyndromic cleft palate (NSCP) development differs from other NSOC. However, most of the publications treat NSCP without considering that information. Furthermore, few studies focus on NSCP. The aim of this study was to describe epidemiological findings of patients with isolated NSCP in Brazil. Methods In this cross-sectional multicenter study, four reference Centers for treatment in three different Brazilian states was investigated. Data were obtained from clinical records of patients, between November 2021 and June 2022. Researched variables were sociodemographic, clinical characteristics and pregnancy and family history. Pearson’s chi-square and ANOVA One-way tests were used for associations. Results Majority were female (58.1%), white (60.7%) with incomplete NSCP (61.2%). There was an association between complete NSCP and a positive history of medical problems during pregnancy (p = 0.016; 27.9%; OR: 1.94; 1.12–3.35). Systemic alterations were perceived in 40.6% of the sample with odds ratio for development of the complete type (OR: 1.21; 0.74–1.97). Higher OR was visualized in medication use during pregnancy (OR: 1.35; 0.76–2.37) and positive family history of oral cleft (OR: 1.44; 0.80–2.55). Dental and surgical care was associated with higher age groups (p < 0.050). Conclusions NSCP was most prevalent in white skin color female. Complete NSCP is associated with medical problems during pregnancy. Medication use during pregnancy and positive family history of oral cleft increase the chance of developing complete NSCP.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Isolated nonsyndromic cleft palate: multicenter epidemiological study in the Brazil

et al. 2023

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“… 22 The bivariate analysis found a statistically significant association between sex and OC type, showing a higher occurrence of CP among women and CL/P among men, as in previous studies. 19 , 20 For maternal age, there is no consensus in the literature. Although the age group from 20 to 29 years was more predominant in this and other studies, 14 , 15 , 23 the literature also points to a higher occurrence of OC in children whose mothers were of intermediate age, up to 34 years of age, 16 , 22 , 23 and advanced age, from 35 years onwards.…”

Section: Discussionmentioning

confidence: 99%

Epidemiologic profile and prevalence of live births with orofacial cleft in Brazil: a descriptive study

Silva,

Calumby,

Freitas

2024

Rev. paul. pediatr.

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Objective: To describe the epidemiological profile and prevalence of live births with orofacial clefts in Brazil between 1999 and 2020. Methods: Descriptive study. The population corresponded to live births with isolated orofacial clefts in Brazil registered in the Live Birth Information System between 1999 and 2020. Descriptive variables were selected according to their availability and grouped into socioeconomic and demographic, maternal and child health care, and biological variables. Data were submitted to a descriptive analysis using the Software for Statistics and Data Science (STATA). Results: During the period, 33,699 children were born with orofacial clefts, and 82.1% (27,677) of them were isolated clefts. Regarding these cases, the majority were cleft lip and palate (9,619 or 34.7%), followed by cleft palate (9,442 or 34.1%), and by cleft lip (8,616 or 31.3%). Conclusions: Live births with orofacial clefts in Brazil were male, white, with birthweight ≥2,500 g and gestational age ≥37 weeks, born by cesarean section, and with Apgar scores ≥7. The cases were more frequent among mothers who were in their first and single pregnancy and had seven or more prenatal appointments. The mothers were 20 and 29 years old, had eight to ten years of study, and were single. The national prevalence of clefts was 4.24/10,000. The South and Southeast regions of Brazil had the highest prevalence, while the lowest prevalence was recorded in the Northeast and North regions. For the Federative Units, the highest and lowest prevalences were found, respectively, in Paraná and Acre.

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Transformative care and remarkable outcomes: illuminating cleft lip and palate management at a premier university center in Saudi Arabia

Mortada,

Alsuhaim,

Alghuligah

et al. 2024

Eur J Plast Surg

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Prevalence of cleft lip and palate and associated factors in Brazil's Midwest: a single-center study

Cited by 5 publications

References 26 publications

Isolated nonsyndromic cleft palate: multicenter epidemiological study in the Brazil

Isolated nonsyndromic cleft palate: multicenter epidemiological study in the Brazil

Epidemiologic profile and prevalence of live births with orofacial cleft in Brazil: a descriptive study

Transformative care and remarkable outcomes: illuminating cleft lip and palate management at a premier university center in Saudi Arabia

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