Prevalence of chronic obstructive pulmonary disease among 48,061 digestive tract cancer patients in Europe

Loosen, Sven H.; Labuhn, Simon; Jördens, Markus S.; Hoyer, Laura; Luedde, Tom; Kostev, Karel; Roderburg, Christoph

doi:10.21037/apm-22-200

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…This finding can be partly explained by regional differences in the incidence of COPD among patients with GC. A study reported that the United Kingdom (8.4%) had the lowest COPD prevalence in Europe, while Germany (13.4%) and Spain (16.8%) had the highest prevalence [ 34 ]. In addition, we found that patients with GC experienced a greater risk of dying from COPD than that expected in the general US population.…”

Section: Discussionmentioning

confidence: 99%

Causes of Death Following Gastric Cancer Diagnosis: A Population-Based Analysis

Lou¹,

Hu²,

Lü³

et al. 2023

Med Sci Monit

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Conflict of interest: None declared Background:Causes of death (CODs) in patients with gastric cancer (GC) need to be studied. We examined the cancer-specific and non-cancer deaths among patients diagnosed with GC from 1975 to 2019. Material/Methods:We obtained medical records from the Surveillance, Epidemiology, and End Results (SEER) database. We used SEER*Stat software to calculate standardized mortality ratios (SMRs) for specific CODs and performed a competing risk analysis to evaluate the cumulative mortality of specific CODs. Results:The final study cohort included 42 813 patients with GC, with a mean age at diagnosis of 67.7 years. As the end of 2021, a total of 36 924 (86.2%) patients died. Of these deaths, 24 625 (66.7%) were from GC, 6513 (17.6%) were from other types of cancers, and 5786 (15.7%) were from non-cancer causes. The most prevalent noncancer CODs were heart diseases (2104; 5.7%), cerebrovascular diseases (501; 1.4%), and pneumonia/influenza (335; 0.9%). Among patients who survived over 5 years, non-cancer causes surpassed GC as the main CODs. Patients with GC had a higher risk of dying from many non-cancer causes than expected in the general population, particularly from suicide (SMR, 3.03; 95% CI, 2.35-3.85) and septicemia (SMR, 2.93; 95% CI, 2.51-3.4).The competing risk analysis showed that the cumulative mortality of GC gradually declined with a more recent diagnosis. Conclusions:Although GC was the leading COD among patients with GC, non-cancer CODs accounted for a substantial number of deaths. These findings provide useful guidance on potential death risks among patients with GC.

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Section: Discussionmentioning

confidence: 99%

Causes of Death Following Gastric Cancer Diagnosis: A Population-Based Analysis

Lou¹,

Hu²,

Lü³

et al. 2023

Med Sci Monit

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Analyses of sex-based clinicopathological differences among patients with gastrointestinal neuroendocrine neoplasms in Europe

Jann

Krieg

et al. 2023

J Cancer Res Clin Oncol

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Background Previous studies have found variations in cancer types, tumor progression, and disease outcomes between men and women. However, there is limited knowledge of the effect of sex on gastrointestinal neuroendocrine neoplasms (GI-NENs). Methods We identified 1354 patients with GI-NEN from the IQVIA’s Oncology Dynamics database. Patients were derived from four European countries (Germany, France, the United Kingdom (UK), Spain). Clinical and tumor related characteristics including patients' age, tumor stage, tumor grading and differentiation, frequency and sites of metastases, as well as co-morbidities were analyzed as a function of patients´ sex. Results Among the 1354 included patients, 626 were female and 728 were male. The median age was similar between both groups (w: 65.6 years, SD: 12.1 vs. m: 64.7 years; SD: 11.9; p = 0.452). UK was the country with the most patients, however, there was no differences in the sex ratio between the different countries. Among documented co-morbidities, asthma was more often diagnosed in women (7.7% vs. 3.7%), while COPD was more prevalent in men (12.1% vs. 5.8%). The ECOG performance states was comparable between females and males. Of note, the patients´ sex was not associated with tumor origin (e.g., pNET or siNET). Females were overrepresented among G1 tumors (22.4% vs. 16.8%), however, median proliferation rates according to Ki-67 were similar between both groups. In line, no differences in tumor stages was found and rates of metastases as well as the specific sites of metastases were similar between males and females. Finally, no differences in the applied tumor specific treatments between the both sexes became apparent. Conclusion Females were overrepresented among G1 tumors. No further sex-specific differences became apparent, highlighting that sex-related factors might play a rather subordinate role in the pathophysiology of GI-NENs. Such data may help to better understand the specific epidemiology of GI-NEN.

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Measurement and optimization of perioperative risk among patients undergoing surgery for esophageal cancer

Elliott,

Guinan,

Reynolds

2023

Diseases of the Esophagus

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Summary Esophagectomy is an exemplar of complex oncological surgery and is associated with a relatively high risk of major morbidity and mortality. In the modern era, where specific complications are targeted in prevention and treatment pathways, and where the principles of enhanced recovery after surgery are espoused, optimum outcomes are targeted via a number of approaches. These include comprehensive clinical and physiological risk assessment, specialist perioperative care by a high-volume team, and multimodal inputs throughout the patient journey that aim to preserve or restore nutritional deficits, muscle mass and function.

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Prevalence of chronic obstructive pulmonary disease among 48,061 digestive tract cancer patients in Europe

Cited by 3 publications

References 9 publications

Causes of Death Following Gastric Cancer Diagnosis: A Population-Based Analysis

Causes of Death Following Gastric Cancer Diagnosis: A Population-Based Analysis

Analyses of sex-based clinicopathological differences among patients with gastrointestinal neuroendocrine neoplasms in Europe

Measurement and optimization of perioperative risk among patients undergoing surgery for esophageal cancer

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