Prevalence of chronic obstructive pulmonary disease in the global population with HIV: a systematic review and meta-analysis

Bigna, Jean Joël; Kenne, Angeladine Malaha; Asangbeh, Serra Lem; Sibetcheu, Aurélie T.

doi:10.1016/s2214-109x(17)30451-5

Cited by 143 publications

(109 citation statements)

References 65 publications

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“…PLWHIV who are current smokers have increased rates of respiratory symptoms, COPD and bacterial pneumonia, and mortality is significantly increased in current versus never smokers . Similarly, as in the meta‐analysis by Bigna et al [. ], we also found that older age was associated with increased odds of airflow obstruction.…”

Section: Discussionsupporting

confidence: 86%

“…However, our prevalence is consistent with that found in a recently published systematic review and meta‐analysis by Bigna et al . based on 30 studies, which found an overall, global prevalence of COPD in PLWHIV of 10.5% (95% CI 6.2–15.7). They included studies that used a variety of methods for diagnosing COPD.…”

Section: Discussionmentioning

confidence: 99%

“…They included studies that used a variety of methods for diagnosing COPD. The global prevalence of COPD in PLWHIV varied from 5.6 to 10.6% depending on the diagnostic criteria used . Adeloye et al .…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and predictors of airflow obstruction in an HIV tertiary care clinic in Montreal, Canada: a cross‐sectional study

et al. 2019

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Objectives The reported prevalence of chronic obstructive pulmonary disease ( COPD ) in people living with HIV ( PLWHIV ) varies widely. Our objective was to estimate the prevalence of airflow obstruction and COPD in unselected PLWHIV and identify characteristics that increase the risk of nonreversible airflow obstruction in order to guide case finding strategies for COPD . Methods All adults attending the Chronic Viral Illness Service were invited to participate in the study, regardless of smoking status or history of known COPD /asthma. Individuals underwent spirometric testing both before and after use of a salbutamol bronchodilator. Airflow obstruction was defined as forced expiratory volume in 1 s ( FEV 1 )/forced vital capacity ( FVC ) < 0.7 post‐bronchodilation, whereas COPD was defined as FEV 1 / FVC < 0.7 post‐bronchodilation and Medical Research Council ( MRC ) score > 2. Multivariate logistic regression was used to evaluate risk factors associated with airflow obstruction, reported as adjusted odds ratios ( aORs ). Results Five hundred and three participants successfully completed spirometry testing. The median (Q1; Q3) age was 52 (44; 58) years. The median (Q1; Q3) CD 4 count was 598 (438; 784) cells/μL and the median (Q1; Q3) nadir CD 4 count was 224 (121; 351) cells/μL. There were 119 (24%) current smokers and 145 (29%) former smokers. Among those screened, 54 (11%) had airflow obstruction whereas three (1%) of the participants had COPD . Factors that were associated with airflow obstruction included a history of smoking [ aOR 2.2; 95% confidence interval ( CI ) 1.1; 4.7], older age (aOR 1.6; 95% CI 1.2; 2.2), and lower CD 4 count (aOR 0.8; 95% CI 0.7; 1.0). Conclusions Airflow obstruction was relatively uncommon. Our findings suggest that PLWHIV who are ≥50 years old, smokers and those with nadir CD 4 counts ≤ 200 cells/μL could be targeted to undergo spirometry to diagnose chronic airflow obstruction.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

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Prevalence and predictors of airflow obstruction in an HIV tertiary care clinic in Montreal, Canada: a cross‐sectional study

et al. 2019

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“…Bigna et al 2 seek to establish the type of relationship between HIV and chronic obstructive pulmonary disease (COPD), following a number of previous studies. They undertook a systematic review and meta-analysis of observational studies of COPD in HIV-positive individuals.…”

Section: Chronic Obstructive Pulmonary Disease In the Context Of Hivmentioning

confidence: 99%

Clinical round-up

Herbert

Chung

2019

Sex Transm Infect

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“…This stimulation could lead to the production of inflammatory cytokines and chemokines, as well as proteases that cause tissue destruction, airway thickening, and clinical expression of COPD. The absence of an association between CD4 cell count and COPD can be explained by the fact that tissue inflammation count in COPD is characterized by the predominance of neutrophils, CD8 cells, and macrophages infiltration, rather than CD4 cell count [98].…”

Section: Hiv/aidsmentioning

confidence: 99%

Chronic obstructive pulmonary disease in non-smokers: An Update

Alvarado¹

2018

Clin Res Trial

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Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Tobacco smoking is established as a major risk factor. However, especially in the last 15 years, there are studies have shown that long-term exposure to biomass fuel smoke to cook and heat homes, also carries a high risk for the development of COPD. This occurs particularly in developing countries, and women and children have the highest exposure rates and are therefore more likely to develop the disease. It is estimated that 25-45% of patients with COPD have never smoked and the burden of COPD not associated with smoking is possibly higher than previously believed. Although exposure to biomass is the major risk factor for COPD not associated with smoking, there are other associated factors such as occupational exposure to dust and gases, history of pulmonary tuberculosis, HIV/AIDS, lower respiratory tract infection (particularly in the childhood), chronic asthma, external pollution and poverty. This review exposes the evidence of this association, and some clinical, functional, anatomopathological and therapeutic aspects and particularly the need for preventive interventions to face this other side of the entity that seems to be increasing.

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Prevalence of chronic obstructive pulmonary disease in the global population with HIV: a systematic review and meta-analysis

Abstract: None.

Cited by 143 publications

References 65 publications

Prevalence and predictors of airflow obstruction in an HIV tertiary care clinic in Montreal, Canada: a cross‐sectional study

Prevalence and predictors of airflow obstruction in an HIV tertiary care clinic in Montreal, Canada: a cross‐sectional study

Clinical round-up

Chronic obstructive pulmonary disease in non-smokers: An Update

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