Prevalence of Chronic Hepatitis B and C in Malaysia- results from a community-based screening campaign

Lim, ZZ; Teo, JS; Tan, AC; Siam, Tan Soek; Mohamed, Rosmawati; Goh, Kazutomo; Jaya, Fauziah; Senamjit, K; Aun, Azlida Che; Said, Rosaida; Lim, EK; Shahar, Hamiza; Radzi, AH Muhammad; Poh, Tee Hoi; Seng, Tan Soon; Menon, Jayaram; Menon, Rena; To, Lim

doi:10.1101/2020.04.30.20085944

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…Chronic hepatitis B (HBV) is endemic in the Asia pacific region [1] including in Malaysia. A recent survey [2] estimated a prevalence of 1.2% amongst multi-ethnic Malaysian population; the disease is particularly common among Chinese with a prevalence of 2.2%. Untreated patients with HBV will progress rapidly to cirrhosis and hepatocellular carcinoma (HCC) [3].…”

Section: Introductionmentioning

confidence: 99%

Cascade of care, awareness and treatment of Chronic Hepatitis B in Malaysia- findings from a community-based screening campaign

Lim¹,

Teo²,

Tan³

et al. 2020

Preprint

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Introduction In 2016 the World Health Organization (WHO) had adopted a global strategy to eliminate Hepatitis B (HBV) by 2030 through five core interventions, the first four were preventive while the fifth is the cascade of care, the continuum of services that persons with chronic HBV should receive as they progress from screening to diagnosis to treatment to chronic care. We determined the prevalence of the awareness and treatment of chronic HBV in Malaysia based on a large sample data from a screening campaign. Methods A total of 10,436 subjects participated in the HBV screening campaign organized by the Hepatitis Free Pahang Malaysia (HFPM) in 2018 and 2019. All screen-positive subjects were recalled to undergo laboratory-based HBsAg and HBV DNA tests. Patients with confirmed chronic HBV were referred to local health services, while continued being monitored by HFPM. Results We estimated 13.1% of Malaysian adults aged 20 or older with chronic HBV were aware of their HBV status, and of those only 0.7% had received prior anti-viral treatment, but among those with baseline HBV DNA level>20,000 IU/ml, 15.6% were subsequently treated. Tenofovir disoproxil fumarate was the only medicine used on all treated patients. The linkage to care post-screening was broken in substantial number of patients, only 108 (54%) subjects had returned to have their HBV DNA measured and only 115 (58%) patients had subsequently sought care and were on still follow-up. Conclusion Few Malaysian adults with HBV were aware of their infection and even less received anti-viral therapy. Concerted public health efforts are urgently needed to improve HBV screening and care cascade in order to meet WHO targets for HBV elimination. Keywords Cascade of care, Awareness, Treatment, Hepatitis B, Malaysia

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Section: Introductionmentioning

confidence: 99%

Cascade of care, awareness and treatment of Chronic Hepatitis B in Malaysia- findings from a community-based screening campaign

Lim¹,

Teo²,

Tan³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Awareness and treatment of chronic hepatitis B in Malaysia-findings from a community-based screening campaign

Lim¹,

Teo²,

Tan³

et al. 2022

BMC Gastroenterol

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Introduction In 2016 the World Health Organization (WHO) had adopted a global strategy to eliminate Hepatitis B (HBV) by 2030 through five core interventions. One of which is the “cascade of care”, the continuum of services that persons with chronic Hepatitis B Virus (HBV) should receive as they progress from screening to diagnosis to treatment to chronic care. We determined the prevalence of the awareness and treatment of chronic HBV in Malaysia based on a large sample data from a screening campaign. Methods A total of 10,436 subjects participated in the HBV screening campaign organized by the Hepatitis Free Pahang Malaysia (HFP). Between in 2018 and 2019, HFP organized a total of 109 health fairs in partnership with local non-governmental organizations (NGO) to conduct HBV screening mostly in small towns and villages largely in the state of Pahang. All screen-positive subjects were recalled to undergo laboratory-based HBsAg and HBV DNA tests. Patients with confirmed chronic HBV were referred to local health services, while continued being monitored by HFP. Results We estimated 13.1% of Malaysian adults aged 20 or older with chronic HBV were aware of their HBV status, and of those only 0.7% had received prior anti-viral treatment, but among those with baseline HBV DNA level > 20,000 IU/ml, 15.6% were subsequently treated. Tenofovir disoproxil fumarate was the only medicine used on all treated patients. Conclusion Few Malaysian adults with HBV were aware of their infection and even less received anti-viral therapy. Concerted public health efforts are urgently needed to improve HBV screening and care cascade in order to meet WHO’s targets for HBV elimination.

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Prevalence of Chronic Hepatitis B and C in Malaysia- results from a community-based screening campaign

Cited by 2 publications

References 26 publications

Cascade of care, awareness and treatment of Chronic Hepatitis B in Malaysia- findings from a community-based screening campaign

Cascade of care, awareness and treatment of Chronic Hepatitis B in Malaysia- findings from a community-based screening campaign

Awareness and treatment of chronic hepatitis B in Malaysia-findings from a community-based screening campaign

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