Prevalence of chronic endometritis in unexplained implantation failure

Abstract

Background: The actual prevalence of chronic endometritis (CE) in the general population is still ill-defined. Aim of the study: was to evaluate the effects of chronic endometritis on implantation failure at ICSI through its prevalence at hysteroscopy and histology, in a population of women who experienced implantation failure at ICSI. Patients and methods: This was a prospective observational cross-sectional study that has been conducted in the International Islamic Center for Population Studies and research – Al Azhar University from 2017 till 2022. The study was conducted on 150 women who were affected by infertility and one unexplained implantation failure or more at ICSI. Results: In our study, hysteroscopy is a reliable diagnostic technique for CE in unexplained implantation failure and is highly reliable in excluding CE with sensitivity, specificity, accuracy, PPV and NPV as 96.5%, 88.17%, 91.3%, 83.3% and, 97.6% respectively. Conclusion: This study suggests that hysteroscopy is a useful diagnostic tool in women with unexplained implantation failure as regard CE diagnosis. However, endometrial samples should be obtained during hysteroscopy to increase the diagnostic accuracy.