Prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium and Trichomonas vaginalis including relevant resistance-associated mutations in a single center in the Netherlands

Nijhuis, Roel H. T.; Duinsbergen, R G; Pol, Arno C.; Godschalk, Peggy C. R.

doi:10.1007/s10096-020-04061-w

Cited by 11 publications

(18 citation statements)

References 16 publications

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“…We hypothesized that this might be due to infection with TV, which is relatively common among people of Surinamese origin 12 . In the Netherlands, prevalence of TV is relatively low (between 0.4% and 0.5%) and therefore not routinely tested for 12,29 . In the study from van der Veer et al, half of the patients with a TV infection were of Surinamese or Dutch Antillean origin.…”

Section: Discussionmentioning

confidence: 99%

“…12 In the Netherlands, prevalence of TV is relatively low (between 0.4% and 0.5%) and therefore not routinely tested for. 12,29 In the study from van der Veer et al, half of the patients with a TV infection were of Surinamese or Dutch Antillean origin. In a subset of 55 of 90 Surinamese men, we found that only one man was infected with TV, so this cannot explain the large proportion of Surinamese men reporting no clinical improvement.…”

Section: Discussionmentioning

confidence: 99%

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Macrolide-Resistant Mycoplasma genitalium Impairs Clinical Improvement of Male Urethritis After Empirical Treatment

et al. 2022

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Background: Mycoplasma genitalium (MG) is associated with urethritis in men and could play a role in clinical outcome. We examined clinical improvement of symptoms in men receiving empirical treatment for urethritis and correlated the outcome with Neisseria gonorrhoeae (NG), Chlamydia trachomatis (CT), MG, and MG macrolide resistance-associated mutations (MRAM) status.Methods: At the sexually transmitted infection clinic in Amsterdam, the Netherlands, empirical treatment for gonococcal urethritis is 1 g ceftriaxone and for nongonococcal urethritis 1 g azithromycin. In 2018 to 2019, we tested urine samples of men with urethritis for CT, NG, and MG using transcription-mediated amplification assays. Mycoplasma genitalium-positive samples were tested for MRAM using quantitative polymerase chain reaction. Two weeks after receiving therapy, men were sent a text message inquiring after clinical improvement. Results:We evaluated 2505 cases of urethritis. The positivity rates of NG,

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Macrolide-Resistant Mycoplasma genitalium Impairs Clinical Improvement of Male Urethritis After Empirical Treatment

et al. 2022

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“…In contrast, fluoroquinolone resistance-associated mutations in M. genitalium are still mainly searched by amplification and sequencing of the target genes. A few attempts to develop commercial kits that directly detect several mutations in the parC gene were published [109,110], but the correlation between certain single nucleotide polymorphisms (SNP) and MICs was not established, jeopardized by the fastidious growth of the bacteria. Additionally, some reported SNPs seem not to be associated with treatment failure [111,112].…”

Section: Genotypic Methodsmentioning

confidence: 99%

Integrating the Human and Animal Sides of Mycoplasmas Resistance to Antimicrobials

Pereyre

Tardy

2021

Antibiotics

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Mycoplasma infections are frequent in humans, as well as in a broad range of animals. However, antimicrobial treatment options are limited, partly due to the lack of a cell wall in these peculiar bacteria. Both veterinary and human medicines are facing increasing resistance prevalence for the most commonly used drugs, despite different usage practices. To date, very few reviews have integrated knowledge on resistance to antimicrobials in humans and animals, the latest dating back to 2014. To fill this gap, we examined, in parallel, antimicrobial usage, resistance mechanisms and either phenotype or genotype-based methods for antimicrobial susceptibility testing, as well as epidemiology of resistance of the most clinically relevant human and animal mycoplasma species. This review unveiled common features and differences that need to be taken into consideration in a “One Health” perspective. Lastly, two examples of critical cases of multiple drug resistance are highlighted, namely, the human M. genitalium and the animal M. bovis species, both of which can lead to the threat of untreatable infections.

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“…However, it is unknown to what extent women over-(or under-) estimated the actual CT complication risks. Furthermore, harms that were not evaluated in this study were those induced by treatment as compromised microbiome, described in a systematic review and metataxonomic analysis [70,71], antimicrobial resistance (AMR) in Neisseria gonorrhoea (NG), Mycoplasma genitalium (MG), syphilis, and other pathogenic microorganisms [72][73][74][75], as well as a possible arrested immune response [76]. Further 'harm' includes economic individual and health care costs ('value for money') and issues related to inequity in health care access.…”

Section: Testing May Also Bring Harmmentioning

confidence: 99%

Controversies and evidence on Chlamydia testing and treatment in asymptomatic women and men who have sex with men: a narrative review

et al. 2022

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Background Chlamydia trachomatis (CT) is the most common bacterial sexually transmitted infection (STI) worldwide. CT is mainly asymptomatic. Test-and-treat strategies are widely implemented to prevent transmission and complications. Strategies are not without controversy in asymptomatic women and men who have sex with men (MSM). Concerns are emerging to test and treat asymptomatic persons for urogenital CT (‘Controversy 1’) and pharyngeal or rectal CT (‘Controversy 2’), whereby testing symptomatic persons is not under debate. Opposed views in CT treatment involve using azithromycin versus doxycycline (‘Controversy 3’). The objective of this review is to provide coverage of these public health and clinical controversies by reviewing the current scientific evidence. Methods A literature search was performed using PubMed for relevant publications between 2018 and September 2021, and iterative retrieval of additional relevant publications. Results Controversy 1. In women, the majority of asymptomatic CT are at the urogenital site, and detections mostly include viable CT. CT easily transmits to a partner and potentially also between the vaginal and rectal areas; the clinical impact of urogenital CT is established, although risks for adverse outcomes are uncertain. Wide-scale testing in asymptomatic women has not resulted in reduced prevalence. In MSM, evidence for the clinical impact of asymptomatic urogenital CT is lacking. Controversy 2. Rectal CT is common in women diagnosed with urogenital CT, but the clinical impact of asymptomatic rectal CT is uncertain. In MSM, rectal CT is common, and most CT infections are at the rectal site, yet the risk of longer term complications is unknown. In both sexes, pharyngeal CT is uncommon and has no documented clinical impact. Controversy 3. In the treatment of rectal CT, doxycycline has superior effectiveness to azithromycin. Evidence has also accumulated on the harms of test-and-treat strategies. Conclusions Current practices vary widely, from widescale test-and-treat approaches to more individual patient- and partner-level case management. Choosing which asymptomatic people to test at what anatomic site, and whether to test or not, requires an urgent (re-)definition of the goals of testing and treating asymptomatic persons. Treatment guidelines are shifting toward universal doxycycline use, and clinical practice now faces the challenge of implementation.

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Prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium and Trichomonas vaginalis including relevant resistance-associated mutations in a single center in the Netherlands

Cited by 11 publications

References 16 publications

Macrolide-Resistant Mycoplasma genitalium Impairs Clinical Improvement of Male Urethritis After Empirical Treatment

Macrolide-Resistant Mycoplasma genitalium Impairs Clinical Improvement of Male Urethritis After Empirical Treatment

Integrating the Human and Animal Sides of Mycoplasmas Resistance to Antimicrobials

Controversies and evidence on Chlamydia testing and treatment in asymptomatic women and men who have sex with men: a narrative review

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