Prevalence of Childhood Celiac Disease and Changes in Infant Feeding

Ivarsson, Anneli; Myléus, Anna; Norström, Fredrik; Pals, Maria van der; Rosén, Anna; Högberg, Lotta; Danielsson, Lars-Göran; Halvarsson, Britta; Hammarroth, Solveig; Hernell, Olle; Karlsson, Εva; Stenhammar, Lars; Webb, Charlotta; Sandström, Olof; Carlsson, Annelie

doi:10.1542/peds.2012-1015

Cited by 179 publications

(209 citation statements)

References 43 publications

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“…[13] However, other hypotheses suggest the higher prevalence of CD may be because of infant feeding practices [14,15] and repeated infections. Previous studies have shown an association between the occurrence of CD and infections.…”

Section: Epidemiologymentioning

confidence: 99%

Celiac Disease in Children: What Has Changed?

Nevoral

2016

IJCD

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The perception of celiac disease (CD) has changed dramatically during the last two decades, with the introduction of new serological tests with high specificity and sensitivity. CD prevalence in recent years is increasing as it is for other autoimmune diseases. Due to the high prevalence of CD, it is one of the most important diseases of the digestive tract. The clinical manifestations of CD have changed significantly in the last two decades, and these are much more diverse than reported previously. The new European Society for Pediatric Gastroenterology, Hepatology, and Nutrition diagnostic criteria for CD indicate that biopsy can be avoided in strictly selected groups of pediatric patients. The first experiences with these new criteria are positive. A meta-analysis evaluating the relationship between early nutrition and the risk of CD recommends that both early (< 4 months) and late (> 7 months) introduction of gluten to the diet should be avoided, and that gluten should be introduced while the infant is still breastfeeding. The prevalence rates of CD between two cohorts with different infant feeding practice were significantly different, and the prevalence of CD in 12-year-old children were significantly reduced, suggesting that prevention of CD is possible.

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Section: Epidemiologymentioning

confidence: 99%

Celiac Disease in Children: What Has Changed?

Nevoral

2016

IJCD

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“…CD's high prevalence, its associated comorbidities in the short and long term, and the fact that an effective treatment is available mean that the disease is a good candidate for a screening program (4,14). Screening would not only detect "subclinical" CD patients but also atypical patients who are difficult to diagnose because of their nonspecific symptoms (15)(16)(17).…”

Section: Analysis Of the Diagnostic Validity Of The Point-of-care Tesmentioning

confidence: 99%

“…It is estimated that for every diagnosed case of CD there are five undetected cases. The estimated global prevalence of CD is between 1 in 100 and 1 in 250, although few specific data about our study population of 2-4-y olds are available (1)(2)(3)(4).…”

mentioning

confidence: 99%

Diagnostic screening for subclinical celiac disease using a rapid test in children aged 2–4

Almazán¹,

Ortega²,

Torres

et al. 2015

Pediatr Res

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Background: Our aim is to study the prevalence of subclinical celiac disease (CD) and analyze the diagnostic yield of a new rapid test in children aged 2-4. Methods: We carried out a cross-sectional study in a sample population of children aged 2-4 from the same metropolitan area. We recruited apparently healthy subjects, and collected clinical, anthropometric, analytical, and serological variables. We also tested for anti-gliadin IgA and anti-transglutaminase IgG and IgA using a rapid immunochromatographic test CD1WB and CD2WB (Operon, Zaragoza, Spain). results: One hundred and ninety-eight children were recruited, signed the informed consent form, and completed the protocol (mean age 32.3 ± 9.2 mo, 53% males). CD prevalence according to the serological tests was 3% (CI 95%, 1.4-6.4%). Biopsies were used to confirm the diagnosis in all suspected cases. The sensitivity and negative predictive value of the CD2WB immunochromatographic test strip were 100% and 1, respectively. The sensitivity of CD1WB was 16.6% and its specificity was high (89.1%). conclusion: The prevalence of subclinical CD in the sample group of 2-4-y old was higher than that found by other authors. The CD2WB immunochromatographic test strip is an excellent diagnostic screening tool with high sensitivity and negative predictive value.

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“…Recent population-based screening studies have revealed it to be one of the most common food-related disorders with an estimated prevalence of 1-3% [1,2]. The disease is initiated when immunological response to gluten leads to inflammation and structural changes of the intestinal mucosa, eventually resulting to characteristic histopathological findings of villous atrophy, crypt hyperplasia, and intraepithelial lymphocytosis.…”

mentioning

confidence: 99%