Prevalence of Chagas heart disease in dilated cardiomyopathy

Abstract

Objectives:The main objective is to determine the prevalence of American trypanosomiasis in patients with dilated cardiomyopathy in a tertiary hospital in western Mexico. Methods: From January 1991 to February 2016, 387 consecutive patients with a confirmed diagnosis of dilated cardiomyopathy were included in the study. Cases with ventricular dilatation secondary to ischemic heart disease, valvular heart disease, hypertension, lung disease, pericardial disease, or congenital heart disease were excluded from the study. Diagnosis was made detecting antibodies against Trypanosoma cruzi with two different methods or parasite in blood. Results: Were included 387 patients with dilated cardiomyopathy, Chagas cardiomyopathy was confirmed in 6.9%, two patients in the acute phase (in one, suspected transfusion transmission was detected). Most patients were born in rural areas. About 96.2% showed congestive heart failure, only one patient with apical left ventricular aneurysm manifested palpitations. About 66% with right bundle branch block, left anterior fascicular block, or the association of both, in 14.8%, non-sustained ventricular tachycardia was found. Conclusions: Chagas cardiomyopathy is common in México, mainly in people who were born or lived during childhood in rural areas. It is a common cause of heart failure. Chagas' heart disease should be suspected in patients receiving a blood transfusion, even without another epidemiological history.

Estudo epidemiológico do comportamento da doença de Chagas no estado do Amapá-Brazil nos anos de 2016 a 2021

“…A DC as vezes é subestimada devido à falta de conhecimento sobre os métodos de transmissão, além da falta de campanhas eficientes para detecção e controle do problema. A principal via de transmissão da doença na América Latina é a via vetorial -triatomíneo; entretanto, a via de transmissão oral tornou-se a principal suspeita na região amazônica brasileira (González-Zambrano et al, 2021). Assim, verificou-se 213 casos confirmados e 1913 casos notificados de DCA, nos municípios do estado do Amapá, durante os anos de 2016 a 2021.…”

Review of American Trypanosomiasis in Southern Mexico Highlights Opportunity for Surveillance Research to Advance Control Through the One Health Approach

“…Although officially reported data increased in the last decade, the true health burden of AT in the Mexican population remains unclear because the disease remains to be fully reported ( 36 , 37 ). Filling this knowledge gap is required to understand the epidemiology of AT transmission, vectorial, or non-vectorial, at the national and regional levels ( 38 , 39 ). Populations in the states of Chiapas and Oaxaca are among the most affected by AT in southern Mexico.…”

Potential distributions of the parasite Trypanosoma cruzi and its vector Dipetalogaster maxima highlight areas at risk of Chagas disease transmission in Baja California Sur, Mexico, under climate change

“…It is currently the most common parasitic infection in Latin America and the third most important worldwide (Pinazo & Gascon, 2015; WHO, 2021). The annual incidence of Chagas disease in the Americas alone reaches 30,000 cases and leads to 14,000 deaths (González‐Zambrano et al, 2020). The global economic burden of CD is approximately estimated as $7.19 billion USD per year (Lee et al, 2013).…”