Prevalence of cervical squamous intraepithelial lesions among HIV-positive women in Enugu, South-eastern Nigeria

Dim, Cyril Chukwudi; Ezegwui, Hyginus U.; Ikeme, A. C.; Nwagha, UI; Onyedum, Cajetan C

doi:10.3109/01443615.2011.598967

Cited by 21 publications

(30 citation statements)

References 13 publications

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“…Out of the 65 HIV positive women screened for premalignant cervical lesions,17 (26.2%) had abnormal cytology result which is higher than 11 (16.9%) among the control group though this was not statistically significant. This prevalence is higher than 12.6% and 4.6% found by Dim et al [27] among HIV positive and HIV negative women respectively. Ezechi et al [28] also found a similar prevalence with Dim, 14.3% and 3.3% among HIV positive and negative women respectively.…”

Section: Prevalence Of Premalignant Cervical Lesions Among Respondentscontrasting

confidence: 55%

Papanicoleau Smear Usage and Prevalence of Premalignant Cervical Lesion among Women Living with HIV Attending a Federal Teaching Hospital in South-West Nigeria: A Comparative Study

Omoragbon¹,

Gabriel²,

Shabi³

et al. 2017

JCTI

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Aim: Cancer of the cervix is the third most common cancer among women worldwide, and in Nigeria it is the second most common female cancer. Infection with the Human immunodeficiency virus (HIV) is associated with an increased risk of prevalent, incident and persistent squamous intraepithelial lesions (SILs) of the cervix. The aim was to determine the level of awareness of cervical cancer screening test and the development of premalignant cervical lesions among HIV positive women. Study Design: A Hospital based comparative cross-sectional study. Place and Duration of the Study:The study was carried out in the HIV clinic and general outpatient clinic of Federal Teaching Hospital Ido-ekiti, Ekiti state Nigeria. It was carried out from July to September 2015.2 Methodology: The study was carried out among 65 HIV-positive and 65 HIV-negative women. Data were collected from the interviewees. Participants also had Pap smear. Data collected were analyzed using statistical package for social sciences version 19. Results: The mean age was 39.73 (Â±8.57) and 40.98 (Â±10.68) among the HIV positive and negative women respectively. Only 27.7% of the HIV-positive women compared to 56.9% of the HIV negative women had heard of cervical cancer with P= 0.001. The level of awareness of cervical cancer screening test was 15.4% and 50.8% among the HIV positive and negative women respectively (P= 0.001). The prevalence of premalignant cervical lesions among the study and control groups was 26.2% and 16.9% respectively. This showed that premalignant cervical lesion was more prevalent among HIV-positive women though not statistically significant (P=0.201). However, using risk ratio (RR), the risk of developing cervical lesions is 1.55 times more in HIV exposed women than HIV negative women. Conclusion: There is therefore need for the Physicians to use every opportunity to counsel their clients on the need for routine cervical cancer screening especially in adult HIV clinics.

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Section: Prevalence Of Premalignant Cervical Lesions Among Respondentscontrasting

confidence: 55%

Papanicoleau Smear Usage and Prevalence of Premalignant Cervical Lesion among Women Living with HIV Attending a Federal Teaching Hospital in South-West Nigeria: A Comparative Study

Omoragbon¹,

Gabriel²,

Shabi³

et al. 2017

JCTI

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“…It is however lower than 68.3 and 43.7% prevalence rates reported in Jos, Nigeria by Agaba et al (2009) and in Kenya by Mabeya et al (2012). A lower rate of 12.6% was reported in Enugu by Dim et al (2011).…”

Section: Discussioncontrasting

confidence: 43%

Sociodemographic determinants of abnormal cervical cytology among HIV positive women in Nnewi, Nigeria

Ugboaja¹,

Oguejiofor²,

Anya³

2017

Int. J. Med. Med. Sci.

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Women living with human immunodeficiency virus (HIV) infection have a higher burden of premalignant.7, p=0.03) and the Anglicans ( 2 =6.7, p=0.04). The prevalence rate was also the highest among women who were para 0-1 (36.6%), unemployed (100.0%), with no formal education (33.3%), and those who were separated from their husbands (100.0%), but these were not statistically significant. The prevalence of cervical cytological abnormalities among the HIV positive women attending the HIV clinic in NAUTH was high. Younger age, being a trader and Anglican Christian denomination were significantly associated with increased risk of premalignant lesions of the cervix.

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“…Several studies in Nigeria have found an association between cervical cancer and HIV [47,55]. A registry linkage study in Nigeria reported a twofold higher risk of cervical cancer in people living with HIV/AIDS [31].…”

Section: Discussionmentioning

confidence: 99%

The burden of HPV associated cancers in two regions in Nigeria 2012–2014

Jedy‐Agba

Dareng

Adebamowo

et al. 2016

Cancer Epidemiology

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Introduction HPV attributable cancers are the second most common infection-related cancers worldwide, with much higher burden in less developed regions. There are currently no country-specific estimates of the burden of these cancers in Nigeria just like many other low and middle income countries. Methods In this study, we quantified the proportion of the cancer burden in Nigeria that is attributable to HPV infection from 2012 to 2014 using HPV prevalence estimated from previous studies and data from two population based cancer registries (PBCR) in Nigeria. We considered cancer sites for which there is strong evidence of an association with HPV infection based on the International Agency for Research on Cancer (IARC) classification. We obtained age and sex-specific estimates of incident cancers and using the World Standard Population, we derived age standardized incidence (ASR) rates for each cancer type by categories of sex, and estimated the population attributable fractions (PAF). Results The two PBCR reported 4336 new cancer cases from 2012 to 2014. Of these, 1627 (37.5%) were in males and 2709 (62.5%) in females. Some 11% (488/4336) of these cancers were HPV associated; 2% (38/1627) in men and 17% (450/2709) in women. Of the HPV associated cancers, 7.8% occurred in men and 92.2% in women. The ASRs for HPV associated cancers was 33.5 per 100,000; 2.3 and 31.2 per 100,000 in men and women respectively. The proportion of all cancers attributable to HPV infection ranged from 10.2 to 10.4% (442–453 of 4336) while the proportion of HPV associated cancers attributable to HPV infection ranged from 90.6% to 92.8% (442–453 of the 488 cases). In men, 55.3% to 68.4% of HPV associated cancers were attributable to HPV infection compared to 93.6% to 94.8% in women. The combined ASR for HPV attributable cancers ranged from 31.0 to 31.7 per 100,000. This was 1.4 to 1.7 per 100,000 in men and 29.6 to 30.0 per 100,000 in women. In women, cervical cancer (n = 392, ASR 28.3 per 100,000) was the commonest HPV attributable cancer, while anal cancer (n = 21, ASR 1.2 per 100,000) was the commonest in men. Conclusions HPV attributable cancers constitute a substantial cancer burden in Nigerian women, much less so in men. A significant proportion of cancers in Nigerian women would be prevented if strategies such as HPV DNA based screening and HPV vaccination are implemented.

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Prevalence of cervical squamous intraepithelial lesions among HIV-positive women in Enugu, South-eastern Nigeria

Cited by 21 publications

References 13 publications

Papanicoleau Smear Usage and Prevalence of Premalignant Cervical Lesion among Women Living with HIV Attending a Federal Teaching Hospital in South-West Nigeria: A Comparative Study

Papanicoleau Smear Usage and Prevalence of Premalignant Cervical Lesion among Women Living with HIV Attending a Federal Teaching Hospital in South-West Nigeria: A Comparative Study

Sociodemographic determinants of abnormal cervical cytology among HIV positive women in Nnewi, Nigeria

The burden of HPV associated cancers in two regions in Nigeria 2012–2014

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