Prevalence of Celiac Disease in Omani Children with Type 1 Diabetes Mellitus: A Cross Sectional Study

Al-Sinani, Siham; Sharef, Sharef Waadallah; Al-Yaarubi, Saif; Al‐Zakwani, Ibrahim; Al-Naamani, Khalid; Al-Hajri, A.; Al-Hasani, Said

doi:10.5001/omj.2013.73

Cited by 17 publications

(12 citation statements)

References 19 publications

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“…The prevalence of biopsy proven celiac disease in Omani children with T1DM was documented to be 5.5%. [7][8][9][10] In the present study peak incidence was in age group of 15-18years (46%). 11 Male predominance was encountered as compared to female.…”

Section: Discussionsupporting

confidence: 53%

Clinical presentations of diabetes in children attending the paediatric ward in the medical institute: a cross sectional study

Vyas

Thacker²

2018

Int J Adv Med

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Background: By 2025, India due to its immense population size and high diabetes prevalence will contribute about 57 million diabetics. Hence the aim of the present study was clinical presentations of diabetes in children attending the paediatric ward in the medical institute.Methods: Total of 50 cases were included in the study. All the children who were less than age of 18years and also diagnosed with diabetes that is fasting blood sugar >126mg/dl or random blood sugar level > 200 mg/dl were included in the study. A detailed clinical examination of the child was carried out with detailed anthropometric measurements. Metabolic profile was done by investigating for the following. Fasting blood sugar, post prandial blood sugar, glycoslated haemoglobin.Results: The various ranges of fasting blood sugar were as follows: 25% were in the range of 130-200mg/dl, 35% in 200-300 mg/dl, 25% in 300-400mg/dl and 15% had more than 400 mg/dl fasting blood sugar levels. The various ranges of post prandial blood sugar were as follows: 16% were in the range of 200 - 300mg/dl, 40% in 300-400mg/dl, 44% had more than 400 mg/dl post prandial blood sugar levels. In the present study lipid profile of all the children was analysed by their serum cholesterol and triglycerides.Conclusions: A total of 50 diabetic children of age less than 18 years attending medical Hospital were studied using a predesigned and pretested proforma. Information was collected on socio-demographic, dietary intake, treatment and compliance history. Detailed clinical examination done and anthropometric measurements were taken. Metabolic profile was done by investigating for blood sugar levels, glycoslated haemoglobin and lipid profile. In the present study 46% had onset of diabetes mellitus at 15 to 18 years age group with male to female ratio of 1.26:1.

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Section: Discussionsupporting

confidence: 53%

Clinical presentations of diabetes in children attending the paediatric ward in the medical institute: a cross sectional study

Vyas

Thacker²

2018

Int J Adv Med

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“…There are limited data on the prevalence of CD in Arab children with T1D. The prevalence in the reported studies from Saudi Arabia, Tunisia, West Algeria, Libya and Oman ranges between 4.9 and 11.3% (8, 9, 10, 11, 12, 13, 14). There are no data about the prevalence of biopsy-proven CD (BPCD) among children and adolescents with T1D from Jordan.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of celiac disease and celiac-related antibody status in pediatric patients with type 1 diabetes in Jordan

Odeh

Alassaf

Gharaibeh

et al. 2019

Endocrine Connections

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Objective Scientific findings regarding the prevalence of celiac disease (CD) in pediatric patients with type 1 diabetes (T1D) in the Arab world are scarce. We aimed to determine the prevalence of biopsy-proven celiac disease (BPCD) among pediatric patients with T1D from Jordan. We also assessed the possible predictors for developing CD in this cohort of patients and we compared T1D patients who developed BPCD with those who had positive CD serology but negative histology and/or fluctuating CD serology. Methods Celiac serology and duodenal biopsy results from 2012 to 2017 were collected from patients with T1D. The outcome of positive celiac serology and the risk factors for CD in T1D patients were investigated. Results A total of 538 children of which 278 boys (51.7%) were included in the study. The prevalence of positive serology and the diagnosis of BPCD in this cohort of T1D patients were 16.6 and 9.1% respectively. Eighty percent of those with BPCD were asymptomatic and 47% were diagnosed with CD at onset of T1D. Spontaneous normalization of celiac serology occurred in 23.6% of those with positive serology. Conclusion CD is prevalent in T1D pediatric patients from Jordan (9.1%). It is often asymptomatic and the majority of cases were diagnosed at onset or within 5 years of T1D diagnosis. Spontaneous normalization of CD serology occurred in some patients with T1D. Hence, a watchful follow-up is recommended in such patients.

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“…The prevalence of CD ranges from 2-3% in Finland and Sweden to only 0.2% in Germany [90], and this is similar to the prevalence of CD in the general population of the Asian-Pacific region. The prevalence of CD in diabetes mellitus type 1 (DM1) patients in Western countries has been reported between 1-12% [91], and is quite similar to that in the Asia-Pacific region, which reported a prevalence of CD between 2.3%-11.3% in DM1 patients [33][34][35][36][37][38][39][40][41][42]. The CD prevalence in DM1 patients was significantly higher in children compared to adults (6% vs. 2.5%; P<0.05) in the Asia-Pacific region.…”

Section: Discussionmentioning

confidence: 98%

Prevalence of gluten-related disorders in Asia-Pacific region: a systematic review

Ashtari

Pourhoseingholi

Rostami

et al. 2019

JGLD

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Background & Aims: The epidemiology of gluten-related disorders (GRDs) is still an open field to be explored. We conducted this systematic review based on the current epidemiology knowledge of GRDs, focusing on the changing prevalence of GRDs reported in the Asia-Pacific region.Methods: We searched Medline, PubMed, Scopus, Web of Science and Cochrane database with the following MeSH terms and keywords: celiac disease (CD), wheat allergy (WA), non-celiac gluten sensitivity (NCGS), dermatitis herpetiformis (DH) and gluten ataxia (GA) and the prevalence studies published from January 1991 to January 2018. Each article was cross-referenced with “Asia-Pacific region” and countries in this regionsuch as Australia, New Zealand, India, Pakistan, Turkey, Iran and others.Results: We included 66 studies, which reported the prevalence of GRDs in the Asia-Pacific region. Prevalence of celiac disease was 0.32%-1.41% in healthy children and 0.05%-1.22% in the adult population, while the prevalence in the high risk population was higher (0.6%-11.8%). Previous studies have shown a very low incidence of dermatitis herpetiformis (DH) (<0.001%) and gluten ataxia (GA) in this area. Few studies on NCGS outbreaks have been found in this area due to the lack of specific diagnostic biomarkers. Wheat allergy (WA), although uncommon in most Asian-Pacific countries, is the most common cause of anaphylaxis in this region.Conclusion: The results of this systematic review suggest the need to plan further proper epidemiological studies in order to understand the natural history of GRDs and to assess its burden on health systems.

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Prevalence of Celiac Disease in Omani Children with Type 1 Diabetes Mellitus: A Cross Sectional Study

Cited by 17 publications

References 19 publications

Clinical presentations of diabetes in children attending the paediatric ward in the medical institute: a cross sectional study

Clinical presentations of diabetes in children attending the paediatric ward in the medical institute: a cross sectional study

Prevalence of celiac disease and celiac-related antibody status in pediatric patients with type 1 diabetes in Jordan

Prevalence of gluten-related disorders in Asia-Pacific region: a systematic review

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