Prevalence of Celiac Disease in Children and Adolescents With Type I Diabetes Mellitus in Southern Poland

Grzenda-Adamek, Zofia; Ciechanowska, Marta; Nazim, Joanna; rska, A G; Fyderek, Krzysztof; Starzyk, Jerzy

doi:10.1097/00005176-200505000-00079

Cited by 3 publications

(6 citation statements)

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“…Sixty‐two studies on the prevalence of CD in patients with type 1 diabetes were included in this review . The prevalence of EMA positivity ranged from 0% to 13.83%; that of elevated tTG levels ranged from 0.81% to 21.16%, while 0.40% to 12.16% showed villous atrophy, ‘flat biopsies’ or Marsh 3 histological changes.…”

Section: Resultsmentioning

confidence: 99%

Systematic review: worldwide variation in the frequency of coeliac disease and changes over time

Kang

Green

et al. 2013

Aliment Pharmacol Ther

227

182

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Summary Background Coeliac disease (CD), originally thought to be largely confined to Northern Europe and Australasia and uncommon in North America and the Middle East, is now recognised to be equally common in all these countries. It is still thought to be rare in the Orient and Sub‐Saharan Africa. Aim To assess geographical differences and time trends in the frequency of CD. Methods Medline and Embase searches were conducted on 10 November 2012, from 1946 and 1980 respectively, using the key words: coeliac disease or celiac disease + prevalence or incidence or frequency. Results There were significant intra‐ and inter‐country differences in the prevalence and incidence of CD. Only 24 ethnic Chinese and Japanese patients have been reported in the English literature. Of CD‐associated HLA DQ antigens, DQ2 occurs in 5–10% of Chinese and sub‐Saharan Africans, compared to 5–20% in Western Europe. DQ8 occurs in 5–10% of English, Tunisians and Iranians, but in <5% of Eastern Europeans, Americans and Asians. The prevalence and incidence of both clinically and serologically diagnosed CD increased in recent years. These geographical and temporal differences seem genuine, although variable indices of suspicion and availability of diagnostic facilities are confounding factors. Conclusions Coeliac disease is increasing in frequency, with significant geographical differences. Although few cases have been described to date in the Orient and Sub‐Saharan Africa, there is a significant prevalence of HLA DQ2 and wheat consumption is of the same order as that in Western Europe. CD may therefore become more common in the future in these countries.

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Section: Resultsmentioning

confidence: 99%

Systematic review: worldwide variation in the frequency of coeliac disease and changes over time

Kang

Green

et al. 2013

Aliment Pharmacol Ther

227

182

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“…The obtained data were compared with the data from our center presented a decade ago [ 14 ]. Statistical analysis of the clinical data was made using Excel (Microsoft Office Professional Plus 2016, PL).…”

Section: Methodsmentioning

confidence: 99%

“…In many Western countries the prevalence of CD shows an increasing tendency [12,13], hence the attempt to reassess this phenomenon in children with type 1 diabetes treated at our Centre. The research regarding the concomitance of T1DM and CD was also carried out a decade ago and published by Grzenda-Adamek et al [14].…”

Section: Introductionmentioning

confidence: 99%

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Increased prevalence of celiac disease and its clinical picture among patients with diabetes mellitus type 1 – observations from a single pediatric center in Central Europe

Wędrychowicz¹,

Minasyan²,

Pietraszek³

et al. 2021

pedm

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The aim of our study was to analyze the incidence and the clinical characteristic of celiac disease (CD) in pediatric population with type 1 diabetes mellitus (T1DM). Materials and methods: The data of 880 patients with T1DM, 429 girls, mean age 12.14 ±4.0 years was retrospectively retrieved from medical records. Patients with T1DM and CD were selected and a detailed analysis of CD prevalence and its clinical characteristic at the time of CD diagnosis was performed. The data were compared with the previous data from our center published a decade ago. Results: CD was suspected in 85/880 patients (9.65%) on the base of results of serological tests, but finally CD was diagnosed in 73/880 patients with T1DM (8.3%), in 53/429 girls (12.3%) and in 20/451 boys (4.4%). Most patients (71%) had CD diagnosed after T1DM onset. The majority of CD patients (72%) was asymptomatic. The CD diagnosis was not associated with inappropriate metabolic control of diabetes. The onset age of diabetes in children with CD was significantly lower than in those without CD (5.8 ±3.6 years vs. 7.56 ±4.0 years, p = 0.04). The prevalence of CD is significantly higher than a decade ago in our center (8.3% vs. 5.7%, p = 0.001). Conclusions: In light of increasing prevalence of mainly asymptomatic CD in patients with T1DM, CD screening is necessary. However positive serological tests, which are currently used in screening, and are the first step of diagnostics, in some patients allow only to suspect the CD and further diagnostic steps should be performed.

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“…Sometimes both conditions are diagnosed concurrently [ 35 ]. The onset age of diabetes in children with CD is usually significantly lower than in those without CD [ 36 ].…”

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confidence: 99%

Coexistance of celiac disease and type 1 diabetes

Szaflarska-Popławska¹

2014

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Prevalence of Celiac Disease in Children and Adolescents With Type I Diabetes Mellitus in Southern Poland

Cited by 3 publications

References 0 publications

Systematic review: worldwide variation in the frequency of coeliac disease and changes over time

Systematic review: worldwide variation in the frequency of coeliac disease and changes over time

Increased prevalence of celiac disease and its clinical picture among patients with diabetes mellitus type 1 – observations from a single pediatric center in Central Europe

Coexistance of celiac disease and type 1 diabetes

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