Prevalence of Celiac Disease in Idiopathic Short Stature Children Presenting in OPD of Children Hospital, Faisalabad

Abstract

Methodology: A total of 300 children with 174 female, 126 males were studied, who came in OPD in Children Hospital Faisalabad for the evaluation of their short stature, excluding familial short stature and other causes of short stature (endocrinal, renal & other chronic illnesses). IgA, TTG & IgG antibodies were evaluated. These antibodies were measured by ELISA method and patients whose TTG antibodies were 10 times greater than normal were spared form duodenal biopsy, however patients having antibodies less than 10 times but greater than normal or having equivocal results were under gone for intestinal biopsy for confirmation of celiac disease. Results: We detected out of 300 patients 88 patients were having TTG titer > 10% of the normal value. 29 patients were having increase titer but less than 10 time of the normal value and 7 patients were found to have equivocal results. So, 36 patients were sent for biopsy out of them 32 were found positive for celiac disease. Hence, we detected 40% (n=120) children were having celiac disease. All 78 females, 42 males having celiac disease were at 2SD except 4 patients who were at 3SD. Conclusion: We conclude that prevalence of celiac disease is high in patients with idiopathic short stature and it is important to investigate all children with ISS for celiac disease by measuring TTG antibodies.

Short Stature and Celiac Disease in Children (5 to 16 Years) Presenting at a Tertiary Care Hospital in Peshawar

“…The mean age of the study was 6.71±1.52 years. Approximately similar mean age (8.368 ± 2.387 years) was reported in a previous study conducted in Faisalabad on the prevalence of CD in idiopathic short stature [12]. Another study conducted in Iran also reported similar mean age [13].…”

“…This shows that short stature equally affects both genders in our population. But a previous study conducted in Pakistan shows female predominance [12].…”

“…Celiac disease was defined as children with positive serologic tests (anti-TTG IgA titer more than 10 times the upper limit of normal. A similar methodology was applied in previous literature [12,13].…”

“…All the children fulfilling inclusion criteria were advised serologic anti-tissue transglutaminase antibodies tests (Anti TTG IgA and Anti TTG IgB). The variables involved in our study are pre-validated in the literature [12].…”

Evaluation of the Relationship Between Celiac Disease and Refractory Epilepsy in Patients Referring to Imam Khomeini Hospital, Urmia

“…For example, its prevalence in Scandinavia is 1.99 %. Recent studies have indicated that the prevalence of celiac disease in the United States is comparable to that in Western Europe ( Xia et al, 2020 ; Masood et al, 2020 ; Rostami et al, 2011 ). The four diagnostic criteria are malabsorption due to gluten consumption in wheat and barley, atrophy of the small intestinal mucosa, the improvement of clinical symptoms of malabsorption with the improvement of atrophic symptoms of the small intestine by cutting gluten-containing foods, and recurrence of clinical and histological symptoms after restarting gluten-containing foods ( Rubio-Tapia et al, 2013 ; Rozenberg et al, 2020 ).…”