Prevalence of Celiac Disease and Follow-up of EMA in Children and Adolescents With Type 1 Diabetes Mellitus

Crone, Julia Sophia; Rami, Birgit; Wd, Huber; Granditsch, G; Schober, Edith

doi:10.1097/00005176-200307000-00011

Cited by 71 publications

(67 citation statements)

References 16 publications

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“…After review of abstracts and full texts, 596 studies were excluded (Fig 1), leaving 9 cohort studies that met the inclusion criteria. 1,7,8,17,[24][25][26][27][28] The studies were from Europe (n = 7) and Australia (n = 2). Study characteristics are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Screening for Celiac Disease in Type 1 Diabetes: A Systematic Review

et al. 2015

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BACKGROUND AND OBJECTIVES: Prevalence rates of type 1 diabetes (T1D) and celiac disease (CD) vary from 1.6% to 16.4% worldwide. Screening guidelines are variable and not evidence based. Our aim was to conduct a systematic review of CD in T1D.METHODS: Medline, Embase, and the Cochrane Library were searched. Studies were limited to those in English and in humans. We selected longitudinal cohort studies screening for CD in T1D with at least 5 years of follow-up. Screening rates, characteristics, and prevalence of biopsy-proven CD in people with T1D were extracted. RESULTS:We identified 457 nonduplicate citations; 48 were selected for full-text review. Nine longitudinal cohort studies in 11 157 children and adolescents with 587 cases of biopsyproven CD met the inclusion criteria. Median follow-up was 10 years (range: 5-18 years). The weighted pooled prevalence of CD was 5.1% (95% confidence interval: 3.1-7.4%). After excluding 41 cases with CD onset before T1D, CD was diagnosed in 218 of 546 (40%) subjects within 1 year, in 55% within 2 years, and in 79% within 5 years of diabetes duration. Two studies (478 cases) reported higher rates of CD in children aged ,5 years at T1D diagnosis. The duration of follow-up varied across the included studies. CD screening frequency progressively decreased with increased T1D duration.CONCLUSIONS: Because most cases of CD are diagnosed within 5 years of T1D diagnosis, screening should be considered at T1D diagnosis and within 2 and 5 years thereafter. CD screening should be considered at other times in patients with symptoms suggestive of CD. More research is required to determine the screening frequency beyond 5 years of diabetes duration.

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Section: Resultsmentioning

confidence: 99%

Screening for Celiac Disease in Type 1 Diabetes: A Systematic Review

et al. 2015

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“…Despite many similarities between DM1 and CD, such as underlying genetic susceptibility associated with HLA class II and autoimmune phenomena, the prevalence rate of CD in DM1 appears to differ greatly in different geographical areas (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Both diseases were associated with a high frequency of HLA DQA1* 0501 and DQB1*0201 (DQ2) molecules worldwide (5).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of celiac disease in patients with type 1 diabetes mellitus in the south of Iran

Honar

Karamizadeh²,

Saki³

2013

Turk J Gastroenterol

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“…23 The previous literature reported contradictory results between the sexes for the prevalence of CD in T1DM. The prevalence was higher in females in some studies, 13,24 higher in males in others, 25,26 and yet other studies reported no difference. 27,28 However, a meta-analysis published in 2014 described no sex predominance in the prevalence of CD in T1DM.…”

Section: Epidemiologymentioning

confidence: 79%

Dietary gluten and the development of celiac disease and type 1 diabetes

Ciacci¹,

Zingone²

2016

NDS

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Abstract:The objective of this study was to perform a review of the present knowledge on the epidemiology and pathogenesis of the association between celiac disease (CD) and type 1 diabetes mellitus (T1DM). Results from this review show that the estimated prevalence rate of CD in T1DM ranges from 4% to 11.5%, which seems higher in children than in adults, while there is no sex predominance in the prevalence of CD in T1DM. On the basis of the previous literature, screening for CD should be considered at diabetes diagnosis in all subjects and again within 2 and 5 years after diagnosis, even in the absence of symptoms. The anti-islet antibodies detection test, instead, is not recommended in CD, just as in the general population, except for CD patients having a relative with T1DM. Both genes and environmental factors seem to play a role in this association. HLADQ2 has been found to be the most frequent allele in the patients with both CD and T1DM, while gluten may be considered the trigger that induces the production of autoantibodies and the development, in genetically predisposed individuals, of both diseases.

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Prevalence of Celiac Disease and Follow-up of EMA in Children and Adolescents With Type 1 Diabetes Mellitus

Cited by 71 publications

References 16 publications

Screening for Celiac Disease in Type 1 Diabetes: A Systematic Review

Screening for Celiac Disease in Type 1 Diabetes: A Systematic Review

Prevalence of celiac disease in patients with type 1 diabetes mellitus in the south of Iran

Dietary gluten and the development of celiac disease and type 1 diabetes

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