Prevalence of celiac disease and its endoscopic markers among patients having routine upper gastrointestinal endoscopy

Dickey, William; Hughes, D.

doi:10.1016/s0002-9270(99)00404-9

Cited by 47 publications

(31 citation statements)

References 19 publications

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“…Based on this method, Dickey and Hughes [15] observed a 1.6% prevalence of CD among individuals submitted to endoscopies owing to digestive complaints (see Table 3). In fact, evaluation of endoscopic results in a large number of patients during standard examinations demonstrated these indicators as being disappointingly insensitive, with markers present in only 58% of those with partial mucosa atrophy [23,24].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Silent Celiac Disease in Patients with Dyspepsia

et al. 2007

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Celiac disease (CD) has become more common than in the past, although it frequently remains undetected for long periods of time. One reason for this is failure by health care professionals to recognize the variable clinical manifestations of CD and to perform the appropriate tests to make the diagnosis. Although dyspepsia may be part of a clinical spectrum in CD patients, there are scarce data about its prevalence in silent CD. We aimed to determine the prevalence of CD in otherwise healthy dyspeptic patients by means of serologic screening followed by endoscopic biopsies if appropriate. Anti-endomysium antibody assay was positive in 3 of 196 patients. All 3 were female, ages ranged from 19-52 years (mean +/- SD age, 36 +/- 16 years). Duodenal biopsies were compatible with CD in all, whereas abnormal endoscopic findings were noted in 2. Therefore, a 1.5% prevalence of CD was observed in this study group. The odds ratio for CD was 2.57 (95% confidence interval) in comparison with the general population. CD should be kept in mind as a cause of dyspepsia during clinical activities. The association between these 2 conditions is, at most, weak, but a gluten-free diet may still bring symptomatic relief for dyspeptic symptoms in CD. During endoscopic examination for dyspepsia, if indicated, endoscopists should carefully inspect the duodenum for CD findings. Although routine serologic screening can not be recommended, it may be appropriate for the patients with refractory dyspepsia, especially females.

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Section: Discussionmentioning

confidence: 99%

“…Endoscopic CD diagnosis was based on well-known markers of CD, namely scalloping of duodenal folds, mosaic mucosal pattern, flattened duodenal folds [15]. Four duodenal mucosal biopsies, 2 from above and 2 from below the major duodenal papilla, were obtained during endoscopy.…”

Section: Endoscopy and Biopsymentioning

confidence: 99%

Prevalence of Silent Celiac Disease in Patients with Dyspepsia

et al. 2007

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“…Endoscopic examination plays an important role in the diagnosis of celiac disease; especially in clinically silent patients, it aids in diagnosis [15]. Abnormalities in the en- doscopic appearance of the second part of the duodenum are loss or flattening of the folds [4], mosaic patterns [16], scalloping [4,17], and a nodular appearance [6]. In 1976, Steven and McCarty were the first to describe a flat mosaic appearance in celiac disease patients [3].…”

Section: Discussionmentioning

confidence: 99%

Correlation of Clinical and Histopathological with Endoscopic Findings of Celiac Disease in the Turkish Population

et al. 2007

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Endoscopic findings have been described for the diagnosis of celiac disease but the relationship among the clinical presentation, endoscopic markers, and the degree of histopathological findings is not clear. Thirty patients who were thought to have celiac disease were included in this study. Biopsies taken from the duodenum were examined histopathologically. The relationship among the endoscopic, clinical, and histopathological findings were investigated. Partial villous atrophy was seen in 14 patients (46.6%), and subtotal and total villous atrophy were seen in 6 (20%) patients each. Eighty six percent of patients with a mosaic appearance, 76% of patients with the finding of loss of folds, and 90% of patients with scalloping on endoscopy had either partial villous atrophy, subtotal villous atrophy, or total villous atrophy on biopsy. We conclude that endoscopic findings in celiac disease can reveal valuable information both for diagnosis and for demonstration of the severity of the disease state.

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“…Although their sensitivity has been demonstrated to vary in different studies (ranging from 6 to 98.7%), these markers are commonly searched to facilitate diagnosis of CD (6,(11)(12)(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

High-Resolution Magnifying Upper Endoscopy in a Patient with Patchy Celiac Disease

Cammarota

Martino

et al. 2005

Dig Dis Sci

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Prevalence of celiac disease and its endoscopic markers among patients having routine upper gastrointestinal endoscopy

Abstract: Careful inspection of the duodenum during routine upper GI endoscopy allows accurate selection of patients for biopsy but may not detect patchy VA or milder enteropathy. Celiac disease should be considered as a cause of dyspeptic and reflux symptoms, as well as of iron-deficiency anemia.

Cited by 47 publications

References 19 publications

Prevalence of Silent Celiac Disease in Patients with Dyspepsia

Prevalence of Silent Celiac Disease in Patients with Dyspepsia

Correlation of Clinical and Histopathological with Endoscopic Findings of Celiac Disease in the Turkish Population

High-Resolution Magnifying Upper Endoscopy in a Patient with Patchy Celiac Disease

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