Prevalence of carotid atherosclerosis and carotid plaque in Chinese adults: A systematic review and meta-regression analysis

Song, Peige; Xia, Wei; Zhu, Yajie; Wang, Manli; Chang, Xiaoxia; Su, Jin; Jing-pin, Wang; An, Lihui

doi:10.1016/j.atherosclerosis.2018.07.020

Cited by 66 publications

(68 citation statements)

References 29 publications

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“…For carotid artery, the prevalence rate varied from 78 to 87% [ 15 , 16 ]. In addition, in the present study, male showed a higher prevalence of multi-site atherosclerosis than female which was consistent with the previous data [ 6 , 12 , 13 ].…”

Section: Discussionsupporting

confidence: 93%

“…Studies showed that traditional risk factors including aging, hypertension, current smoking, diabetes and the level of HDL-C were associated with subclinical carotid atherosclerosis and plaque burden [ 6 , 15 , 17 ]. In our study from in-hospital population, we also found CF-PWV, age, sex, stroke, PAD, dyslipidemia, hypoglycemic agents and smoke were independently associated with multi-site atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

“…A meta-analysis indicated that 27.22% of Chinese people aged 30-79 years were with carotid atherosclerosis in 2010, equivalent to 207.73 million affected individuals. With demographic ageing, the number of people affected by carotid atherosclerosis will increase to 267.25 million by 2020 [6]. Carotid atherosclerosis alone has such a high disease burden that it is necessary to assess atherosclerosis in other vascular beds, such as subclavian artery, abdominal aorta and lower extremities arteries.…”

Section: Introductionmentioning

confidence: 99%

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Association between multi-site atherosclerotic plaques and systemic arteriosclerosis: results from the BEST study (Beijing Vascular Disease Patients Evaluation Study)

Liu

Wang

Huang

et al. 2020

Cardiovasc Ultrasound

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Background: Arteriosclerosis can be reflected in various aspect of the artery, including atherosclerotic plaque formation or stiffening on the arterial wall. Both arteriosclerosis and atherosclerosis are important and closely associated with cardiovascular disease (CVD). The aim of the study was to evaluate the association between systemic arteriosclerosis and multi-site atherosclerotic plaques. Methods: The study was designed as an observational cross-sectional study. A total of 1178 participants (mean age 67.4 years; 52.2% male) enrolled into the observational study from 2010 to 2017. Systemic arteriosclerosis was assessed by carotid femoral artery pulse wave velocity (CF-PWV) and multi-site atherosclerotic plaques (MAP, > = 2 of the below sites) were reflected in the carotid or subclavian artery, abdominal aorta and lower extremities arteries using ultrasound equipment. The associations were assessed by multivariable logistic regression. Results: The prevalence of CF-PWV > 12 m/s and MAP were 40.2% and 74.4%. Atherosclerotic plaques in 3 sites were more common in male compared with that in female (48.9% versus 36.9%, p < 0.05). All CVD factors were worse in participants with MAP than that with <=1 site. Participants with CF-PWV > 12 m/s corresponded to a mean 82% probability of MAP with age and sex-adjusted. Patients with peripheral artery disease showed the highest odds ratio (OR) (3.88) for MAP, followed by smoking (2.485), CF-PWV > 12 m/s (2.25), dyslipidemia (1.89), male (1.84), stroke (1.64), hypoglycemic agents (1.56) and age (1.09) (all p < 0.001). Conclusions: MAP was highly prevalent in this cohort, with male showing a higher prevalence than female. Higher systemic arteriosclerosis was independently associated with MAP, which indicating the supplementary value of arteriosclerosis for the earlier identification and intervention on MAP. Trial registration: Clinical Trial, URL: http://www.clinicaltrials.gov. Unique identifier: NCT02569268.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between multi-site atherosclerotic plaques and systemic arteriosclerosis: results from the BEST study (Beijing Vascular Disease Patients Evaluation Study)

Liu

Wang

Huang

et al. 2020

Cardiovasc Ultrasound

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“…The study also showed that, increased CIMT is associated with poorer prognosis and lesser functional outcome. These results agree with the work of Song et al, 2018 [16] who declared that increased CIMT was an independent risk of LIs and associated with poorer outcome due to its high association with vascular risks and increased tissue inflammatory markers. On the contrary, Polak and O'Leary, 2016 [17] stated that increased CIMT may not associated with higher LIs induced motor disability as it is more related to large vessel atherosclerosis than Small Vessel Disease (SVD).…”

Section: Discussionsupporting

confidence: 93%

Early Prediction of Functional Outcome after Cerebral Small Arteries Infarctions Using Diffusion Tensor MRI Tractography

El-Shafey

Dawoud

2019

The Medical Journal of Cairo University

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Background: Lacunar Infarctions (LIs) are ischemic strokes caused by occlusion of the deep penetrating arteries. They constitute about 25% of all ischemic strokes and have variable consequences based on affected tracts disruptions. Aim of Study: Were to assess the role of MRI Diffusion Tensor Imaging (DTI) fiber tractography as an early biomarker of LIs prognosis. Patients and Methods: This work was conducted on 42 first-ever symptomatic motor or sensorimotor LIs patients (3 1 male and 11 female) submitted to stroke severity assessment using the National Institute of Health Stroke Scale (NIHSS), carotid duplex, brain MRI to determine LIs dimeter and occult small vessel disease imaging markers. Corticospinal Diffusion Tensor Tractography (CS-DTT) was done within 48 hours from stroke onset. Thirty-eight patients continued a 3-months follow-up schedule, at the end of which their physical dependences were assessed using the Modified Barthel Index (MBI) scale which were compared with the baseline assessment parameters to determine the prognostic biomarkers. Results: Dependent patients' group showed significant increase in their age, BMI, carotid intima media thickness and white matter hyperintensities grade than independent patients' group. The FA ratio was the earliest parameter showed significant changes which were lower in dependent than independent patients' groups. On the other hand, each of ipsilateral DTI fractional anisotropy, mean diffusivity and fiber number showed non-significant differences. Conclusion: Factors associated with poorer functional outcome after newly diagnosed LIs include advanced age, hypertension, obesity, premorbid physical inactivity, increased CIMT and the presence of imaging biomarkers of occult SVD. Reduced ipsilateral/contralateral FA ratio of the CS-DTT is a reliable early predictor of short-term functional outcome and motor disability after motor and sensorimotor LIs.

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“…In this study, it was found that the prevalence of increased IMT, carotid plaque and CAS in the general population older than 40 years in northeast China was 3.2%, 48.6% and 4.0%, respectively, significantly higher than the prevalence noted in the China National Stroke Prevention Project and systematic reviews [2,3], indicating the massive cervical arterial atherosclerosis burden in northeast China. Jilin Province is one of the regions with the heaviest burden of CAS, cervical artery stenosis; CHD, coronary heart disease; DBP, diastolic blood pressure; FPG, fasting plasma glucose; HDL-C, high-density lipoprotein cholesterol; IMT, intima-media thickness; LDL-C, low-density lipoprotein cholesterol; NIAAA, National Institute on Alcohol Abuse and Alcoholism; SBP, systolic blood pressure; TC, total cholesterol; TG, triglyceride.…”

Section: Discussionmentioning

confidence: 52%

Visceral adiposity index and cervical arterial atherosclerosis in northeast China: a population based cross‐sectional survey

Zhang

Yan

et al. 2020

Euro J of Neurology

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Background and purpose: The burden of cervical arterial atherosclerosis, which is an important risk factor of stroke, is huge in China. The visceral adiposity index (VAI) is a convenient index that is related to a series of metabolic abnormalities and a variety of diseases, including cerebrovascular diseases. This study aimed to explore the relationship between VAI and cervical arterial atherosclerosis. Methods: This cross-sectional study used the multistage stratified random cluster sampling method to acquire a representative sample of residents aged ≥40 in the general population of northeast China. All participants completed a detailed questionnaire and provided blood samples. Cervical vascular ultrasound was performed by experienced ultrasound doctors. VAI was calculated by a well-established formula and analyzed by quartiles (Q1-Q4). Results: A total of 3688 people aged ≥40 years who underwent cervical arterial ultrasound were finally included, amongst whom 3.2% had increased intima-media thickness (IMT), 48.6% had carotid plaque and 4.0% had cervical artery stenosis (CAS). After adjusting for several parameters, little statistical significance was found between VAI and increased IMT; compared with the VAI-Q1 group, the VAI-Q2, VAI-Q3 and VAI-Q4 groups were more likely to have CAS [odds ratio (OR) 2.01, 95% confidence interval (CI) 1.17-3.43; OR 1.82, 95% CI 1.05-3.15; OR 1.79, 95% CI 1.03-3.12] and the VAI-Q3 and VAI-Q4 groups were at greater risk of carotid plaque (OR 1.30, 95% CI 1.05-1.62; OR 1.34, 95% CI 1.07-1.67). Conclusions: The VAI was related to carotid plaque and CAS in the general population that is older than 40 years.

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Prevalence of carotid atherosclerosis and carotid plaque in Chinese adults: A systematic review and meta-regression analysis

Cited by 66 publications

References 29 publications

Association between multi-site atherosclerotic plaques and systemic arteriosclerosis: results from the BEST study (Beijing Vascular Disease Patients Evaluation Study)

Association between multi-site atherosclerotic plaques and systemic arteriosclerosis: results from the BEST study (Beijing Vascular Disease Patients Evaluation Study)

Early Prediction of Functional Outcome after Cerebral Small Arteries Infarctions Using Diffusion Tensor MRI Tractography

Visceral adiposity index and cervical arterial atherosclerosis in northeast China: a population based cross‐sectional survey

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