Prevalence of cardiovascular risk factors in patients with psoriasis

Neimann, Andrea L.; Shin, Daniel B.; Wang, Xingmei; Margolis, David J.; Troxel, Andrea B.; Gelfand, Joel M.

doi:10.1016/j.jaad.2006.08.040

Cited by 893 publications

(1,017 citation statements)

References 41 publications

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“…PsO/PsA‐related comorbidities included hyperlipidemia, hypertension, diabetes mellitus, obesity, coronary heart disease, acute myocardial infarction, stroke, peripheral vascular disease, depression, anxiety, rheumatoid arthritis, Crohn's disease or ulcerative colitis, other autoimmune disorders (including alopecia areata, celiac disease, systemic sclerosis, Sjögren's syndrome, vitiligo, chronic urticaria, systemic lupus erythematosus, Addison's disease, giant cell arteritis, pulmonary fibrosis, and chronic glomerulonephritis), multiple sclerosis, skin cancer, lymphoma, and other malignancies (including cancers of the lung, pharynx, liver, pancreas, breast, vulva, penis, bladder, and kidney) 9, 10, 11, 12, 13, 14, 15, 16 (for ICD‐9‐CM codes, see Supplementary Appendix D, available in the online version of this article at http://onlinelibrary.wiley.com/doi/10.1002/acr.22492/abstract).…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, compared with the general population, patients with PsO/PsA face an elevated burden of cardiovascular diseases due to a higher prevalence of cardiovascular risk factors such as metabolic syndrome and chronic inflammation in PsO/PsA 14, 15, 16. Due to the multisystem involvement of PsO and PsA, a new terminology, psoriatic disease, has been suggested that encompasses a wide array of musculoskeletal manifestations and extraarticular features 17.…”

Section: Introductionmentioning

confidence: 99%

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Economic and Comorbidity Burden Among Moderate‐to‐Severe Psoriasis Patients with Comorbid Psoriatic Arthritis

Feldman

Zhao

Shi

et al. 2015

Arthritis Care & Research

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ObjectiveTo compare the prevalence of comorbidities, health care utilization, and costs between moderate‐to‐severe psoriasis (PsO) patients with comorbid psoriatic arthritis (PsA) and matched controls.MethodsAdults ages 18–64 years with concomitant diagnoses of PsO and PsA (PsO+PsA) were identified in the OptumHealth Reporting and Insights claims database between January 2007 and March 2012. Moderate‐to‐severe PsO was defined based on the use of at least one systemic or phototherapy during the 12‐month study period after the index date (randomly selected date after the first PsO diagnosis). Control patients without PsO and PsA were demographically matched 1:1 with PsO+PsA patients. Multivariate regressions were employed to examine PsO/PsA‐related comorbidities, medications, health care utilization, and costs between PsO+PsA patients and controls, adjusting for demographics, index year, insurance type, and non–PsO/PsA‐related comorbidities.ResultsAmong 1,230 matched pairs of PsO+PsA patients and controls, PsO+PsA patients had significantly more PsO/PsA‐related comorbidities, with the top 3 most common in both groups being hypertension (35.8% versus 23.5%), hyperlipidemia (34.6% versus 28.5%), and diabetes mellitus (15.9% versus 10.0%). Compared with controls, PsO+PsA patients had a higher number of distinct prescriptions filled (incidence rate ratio 2.3, P < 0.05); were more likely to have inpatient admissions (odds ratio [OR] 1.6), emergency room visits (OR 1.3), and outpatient visits (OR 62.7) (all P < 0.05); and incurred significantly higher total, pharmacy, and medical costs (adjusted annual cost differences per patient $23,160, $17,696, and $5,077, respectively; all P < 0.01).ConclusionCompared with matched PsO‐ and PsA‐free controls, moderate‐to‐severe PsO patients with comorbid PsA had higher comorbidity and health care utilization and costs.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Economic and Comorbidity Burden Among Moderate‐to‐Severe Psoriasis Patients with Comorbid Psoriatic Arthritis

Feldman

Zhao

Shi

et al. 2015

Arthritis Care & Research

View full text Add to dashboard Cite

show abstract

“…30 Smoking has well known links to hypertension, peripheral vascular disease, stroke and myocardial infarction. 31 An increased prevalence of smoking among psoriasis patients has been noted in Finland, 32 Italy, 10, 33 UK, 13,34 Norway, 35 China, 12 and the US 9 . In the Utah Psoriasis Initiative (UPI) database (>800 subjects) it was found that 37% (p<0.001) of psoriatics smoke vs. 13% in the general population.…”

Section: Smokingmentioning

confidence: 99%

“…Specifically, a large population-based study demonstrated an increased risk of MI in patients with psoriasis (particularly those with severe disease) even when accounting for major cardiovascular risk factors such as obesity, smoking, diabetes, hypertension, and diabetes. 4,13 Similarly, a small study of a well-defined population of patients with very severe psoriasis demonstrated that these patients had a higher frequency of coronary artery disease compared to controls even when controlling for known risk factors for atherosclerosis. 3 These studies, taken together, suggest that psoriasis itself may be a risk factor for developing atherosclerosis and MI.…”

Section: General Cardiovascular Riskmentioning

confidence: 99%