Prevalence of cardiovascular autonomic neuropathy and gastroparesis symptoms among patients with type 2 diabetes who attend a primary health care center

AlOlaiwi, Lina A.; Alharbi, Turki; Tourkmani, Ayla M.

doi:10.1371/journal.pone.0209500

Cited by 15 publications

(15 citation statements)

References 57 publications

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“…Of these78 cases, 16 had Grade I cardiac autonomic neuropathy, 28 and 34 Grade II and Grade III cardiac autonomic neuropathy respectively. Similarly a study done by Lina Alolaiwi et al, 11 presented that the CAN was present in 15.6%: 2.9% with OH, 5.8% with RT and 8.4% with prolonged QTc. Prolonged T2D duration and anti-HTN were independently associated with CAN.…”

Section: Discussionsupporting

confidence: 53%

Gall bladder ejection fraction as a marker of autonomic neuropathy in type 2 diabetes mellitus

Kalyani¹,

Sheela²,

Kumar³

et al. 2019

Int J Res Med Sci

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Background: Diabetic neuropathy is one of the commonest complications of diabetes mellitus and associated with considerable morbidity and mortality. The influence of diabetes on gall bladder function was not demonstrated in many studies. In this study, the association of fasting gall bladder volume and gall bladder ejection fraction with degree of cardiac autonomic neuropathy was assessed and correlated with duration of diabetes and severity of diabetes..Methods: The study was conducted in Government Sivagangai Medical College Hospital, Sivagangai, Madurai during a period of January 2018 to September 2018 as a Prospective observational study conducted among 100 patients in study group and 50 healthy subjects in control group. The aim of the study was to find out the incidence of autonomic neuropathy in study group by simple bed side tests, to determine the fasting gall bladder ejection fraction in diabetics, comparison of gall bladder volume in both study and control group, correlation of gall bladder ejection fraction with autonomic neuropathy.Results: The incidence of CAN is found to be high with longer duration of the disease and the degree is also correlated with duration of the disease. The correlation coefficient of this association is 0.792 which indicates high correlation. The correlation of severity of DM with incidence and degree of CAN was 0.81 which indicates high correlation and also the study showed an increase in the FGBV and a decrease in the GBEF with increase in the severity of cardiac autonomic neuropathy.Conclusions: In patients with type 2 diabetes mellitus, the gall bladder ejection fraction is significantly related to the duration of diabetes mellitus and degree of hyperglycemia in addition to cardiac autonomic neuropathy(CAN). Similarly, fasting gall bladder volume (FGBV) is significantly increased in type 2 diabetes mellitus patients with cardiac autonomic neuropathy.

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Section: Discussionsupporting

confidence: 53%

Gall bladder ejection fraction as a marker of autonomic neuropathy in type 2 diabetes mellitus

Kalyani¹,

Sheela²,

Kumar³

et al. 2019

Int J Res Med Sci

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“…[ 6 19 ] The prevalence of CAN is shown to corelate with population characteristics specifically increasing age, duration of diabetes and glycemic control attributing to the differences in prevalence of CAN amongst various studies. [ 6 19 20 21 22 ]…”

Section: Discussionmentioning

confidence: 99%

Age and Disease Duration Independent Cardiac Autonomic Neuropathy in Patients with Diabetic Foot Complications

Wadhera

Rastogi

Dutta

et al. 2022

Indian Journal of Endocrinology and Metabolism

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Introduction: Cardiac autonomic neuropathy (CAN) in people with diabetes is associated with high mortality. We aimed to study age and disease duration, independent prevalence of CAN in people with diabetic foot complications. Methods: 530 patients with diabetes were screened to undergo CAN assessment (automated CANS-analyser). CAN was defined as “early”, “definite,” or “severe” according to the Toronto consensus. History pertaining to autonomic symptoms, prior cardiovascular events (CVE), and assessment for peripheral neuropathy was done. Participants were grouped into those with diabetic foot complication (group A, n = 82) [Charcot foot (n = 42), diabetic foot ulcer (n = 40)]; with DPN without foot complications (group B, n = 82); and without DPN or foot complications (group C, n = 82). Results: Symptoms of autonomic dysfunction were prominent in people with foot complications than the other groups. Resting heart rate was significantly greater in those with foot complications [99.89 ± 26.71 (group A) vs. 86.99 ± 22.24 (group B) vs. 88.32 ± 17.08 (group C); P = 0.001]. The prevalence of CAN was 75.6% in group A (51.2% early, 12.2% definite, 12.2% severe), 57.2% in group B (45.1% early, 12.2% severe) and 58.5% in group C (43.9% early, 1.2% definite, 13.4% severe) (P = 0.002). Patients with foot complications were more likely to have CAN (75.6% vs. 57.9%, P < 0.001). Charcot foot had higher prevalence of CAN (78.6%) as compared with those with DFU (72.5%) or without DFU or DPN (57.9%), P < 0.001. Conclusion: CAN is present in more than two-third of patients with diabetes and foot complications with highest prevalence in Charcot neuroarthropathy.

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“…Although the great difference in the prevalence of OH between the two populations is highlighted, this finding differs from the prevalence of 15.3% found in the literature of diabetic neuropathy, including orthostatic hypotension in the general population of people affected by DM2. 18 However, the prevalence of OH ranges from 31 to 73% according to the diagnostic method; population studied and associated risk factors. 19 In the Brazilian population, there was no statistically significant difference for gender, body mass index, smoking, coronary heart disease complications, heart failure and cerebrovascular disease and the presence of orthostatic hypotension, as in the American study of 302 older adults.…”

Section: Discussionmentioning

confidence: 99%

“…This difference can be related to the expected evolution of the disease with complications that would be more prevalent in a period of disease equal to or greater than 10 years, mainly in the age group of 60-69, considering that age and time of illness can be independent predictors for the clinical evolution of DM and orthostatic hypotension as its complication. 18,24 The activation of inflammatory cytokines plays an important role in the balance of the sympathetic system in diabetic patients, with inflammatory markers such as elevated CRP, IL-6 and TNF, exerting an inflammatory response in the adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

Orthostatic Hypotension and associated factors in older adults Brazilian and French with diabetes

Bezerra¹,

Carvalho²,

Saintrain³

et al. 2021

IJAERS

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Diabetic neuropathy is one of the major chronic complications of diabetes, including different clinical manifestations affecting the peripheral nervous system. The study aims to describe the characteristics of the older people with type 2 diabetes mellitus in Brazil and France who presented orthostatic hypotension and associated factors. This is a cross-sectional descriptive and analytical study, in which 248 Brazilian older adults with diabetes aged 65 or more and 987 older adults French with aged 75 or over, evaluated for the outcome of orthostatic hypotension, having the associated factors related to complications been analyzed. It was evident that ⅔ of the older adults Brazilian with diabetes 162 (69.8%) presented orthostatic hypotension on examination, while less than ⅓ of the French older adults with diabetes [301 (30.5%)] displayed this change on clinical examination, with statistically significant differences between the two populations for the variables: age, duration of diabetes, smoking, body mass index, degree of hypertension, diabetic neuropathy, amputations, obstructive limb arteriopathy, and use of antihypertensive drugs. The study reinforces the importance of tracking this important alteration of the physical examination, which may result in relevant chronic complication to the health of the older people with diabetes.This global phenomenon experienced by several countries in different periods contributed to a higher prevalence of chronic non-communicable diseases (NCDs) such as cardiovascular diseases, neoplasia, chronic respiratory diseases, and diabetes mellitus. Among them, diabetes stands out as the causes of high morbidity and mortality in Brazil, besides causing important economic repercussions. 2 The World Health Organization (WHO) estimates that in 2030 Brazil will have a population of approximately 21.5 million diabetics, 3 and that 33% of that population will be represented by people in the age group between 60 and 79. 4 It is relevant to mention that the number of diabetics in the world population tends to increase, according to the following estimates: 463 million in 2019, 578 million in 2030 and 700 million in 2045. 3

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Prevalence of cardiovascular autonomic neuropathy and gastroparesis symptoms among patients with type 2 diabetes who attend a primary health care center

Cited by 15 publications

References 57 publications

Gall bladder ejection fraction as a marker of autonomic neuropathy in type 2 diabetes mellitus

Gall bladder ejection fraction as a marker of autonomic neuropathy in type 2 diabetes mellitus

Age and Disease Duration Independent Cardiac Autonomic Neuropathy in Patients with Diabetic Foot Complications

Orthostatic Hypotension and associated factors in older adults Brazilian and French with diabetes

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