Prevalence of Cardiometabolic Disease Risk Factors in People with HIV Initiating Anti-retroviral Therapy at a High-Volume HIV Clinic in Kampala, Uganda

Amutuhaire, Willington; Mulindwa, Frank; Castelnuovo, Barbara; Brusselaers, Nele; Schwarz, Jean-Marc; Mutebi, Edrisa; Dujanga, Simon; Salata, Robert A.; Yendewa, George A.

doi:10.1093/ofid/ofad241

Cited by 2 publications

(1 citation statement)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, 29.4% had pre-hypertension, indicating a concerning trend, considering that the median age of this cohort of patients was only 33 years. Our findings support current research from the WHO African region which has shown substantially high rates of hypertension among both ART-naïve and -exposed PWH [20][21][22][23]. The findings of this study contribute to the limited literature on hypertension among PWH in Sierra Leone specifically and may provide valuable insights for HIV care providers and policymakers in designing appropriate interventions to address the growing burden of hypertension and CVDs in this vulnerable population.…”

Section: Discussionsupporting

confidence: 85%

Hypertension Among Adults With HIV Initiating Antiretroviral Therapy in Freetown, Sierra Leone: A Cross-sectional Study

Yendewa

Jiba²,

Barrie

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Hypertension is a major contributor to cardiovascular morbidity and mortality in people with HIV (PWH). However, screening and identification among PWH initiating antiretroviral therapy (ART) in sub-Saharan Africa is understudied. We aimed to assess the prevalence of hypertension and its associated factors among newly diagnosed PWH in Freetown, Sierra Leone. Methods: We used a cross-sectional study design to assess the baseline characteristics of newly diagnosed ART-naive PWH at Connaught Hospital in Freetown from March 2021 to March 2022. We categorized patients as having normal blood pressure (<120/80mmHg), pre-hypertension (systolic >120-139 mmHg and diastolic ≤80-89 mmHg), and hypertension (systolic ≥140 mmHg or diastolic ≥90 mmHg). We used logistic regression models to identify factors associated with hypertension. Results: 918 PWH were studied (55.0% female, median age 33 years). The prevalence of hypertension was 20.0% and 29.5% were pre-hypertensive. In univariate analysis, hypertension prevalence increased with age, body mass index (BMI), smoking, alcohol consumption, and being Christian (all p < 0.05). In multivariate logistic regression analysis, ages 40-49 years (aOR 2.15, 95% CI 1.30-3.57), 50-59 years (aOR 2.30, 95% CI 1.26-4.18), ≥ 60 years (aOR 3.08, 95% CI 1.28-7.41), BMI ≥ 30 kg/m2 (aOR 2.34, 95% CI 1.11-4.93), identifying as a Christian (aOR 1.45, 95% CI 1.01-2.11), and smoking (aOR 1.67, 95% CI 1.04-2.69) were significantly associated with hypertension. Conclusions: We observed a significant burden of hypertension among ART-naive PWH in Sierra Leone, emphasizing the importance of early identification and management of hypertension to reduce cardiovascular morbidity and mortality.

show abstract

Section: Discussionsupporting

confidence: 85%

Hypertension Among Adults With HIV Initiating Antiretroviral Therapy in Freetown, Sierra Leone: A Cross-sectional Study

Yendewa

Jiba²,

Barrie

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

The association of aspartate transaminase-to-alanine transaminase ratio and metabolic syndrome among HIV patients in Sidama Region, South Ethiopia

Abera,

Wube,

Alemayehu

2023

SAGE Open Medicine

View full text Add to dashboard Cite

Objective: Studies on the association of the aspartate transaminase-to-alanine transaminase ratio with the metabolic syndrome and its components among HIV patients were scarce. This study aims to determine the association between the aspartate transaminase-to-alanine transaminase ratio and the metabolic syndrome and its components in adult HIV patients on highly active antiretroviral therapy. Methods: This was a cross-sectional study conducted on 302 HIV patients from January 15 to June 30, 2021. Sociodemographic, clinical, and anthropometric data were collected using a structured questionnaire. The patient’s medical records were reviewed. Biochemical analysis was performed after 5 ml of venous blood was collected from each study participant. Metabolic syndrome was defined by the third report of the national cholesterol education program-adult treatment panel. Logistic regression was done to assess the association of MetS with the independent variables, and correlation analysis was performed to see the correlation of MetS components with the aspartate aminotransferase-to-alanine aminotransferase ratio. Result: 302 HIV—positive patients on highly active antiretroviral therapy were included in this study, and 54.6% were female. The median and interquartile range of the age of the study participants were 41 (35–50) years. The prevalence of metabolic syndrome was 29.5% (confidence interval = 24.5–35.1). Chronic illness (Adjusted odds ratio = 4.8, confidence interval = 2.2–10.9) and aspartate aminotransferase-to-alanine aminotransferase ratio (adjusted odds ratio = 2.5, confidence interval = 1.4–4.4) were significantly associated with Metabolic syndrome among the study participants. The aspartate aminotransferase-to-alanine aminotransferase ratio was significantly correlated with blood pressure. Conclusion: This study found the existence of a significant association between the aspartate aminotransferase-to-alanine aminotransferase ratio and metabolic syndrome among HIV patients.

show abstract

Prevalence of Cardiometabolic Disease Risk Factors in People with HIV Initiating Anti-retroviral Therapy at a High-Volume HIV Clinic in Kampala, Uganda

Cited by 2 publications

References 58 publications

Hypertension Among Adults With HIV Initiating Antiretroviral Therapy in Freetown, Sierra Leone: A Cross-sectional Study

Hypertension Among Adults With HIV Initiating Antiretroviral Therapy in Freetown, Sierra Leone: A Cross-sectional Study

The association of aspartate transaminase-to-alanine transaminase ratio and metabolic syndrome among HIV patients in Sidama Region, South Ethiopia

Contact Info

Product

Resources

About