Prevalence of Candida albicans in primary endodontic infections associated with a higher frequency of apical periodontitis in type two diabetes mellitus patients

Torre-Luna, Rocio De la; Domínguez-Pérez, Rúben Abraham; Guillén-Nepita, Ana Laura; Áyala-Herrera, José Luis; Martínez-Martínez, Rita Elizabeth; Romero-Ayala, Ma Esther; Pérez-Serrano, Rosa M.; Vázquez-Garcidueñas, Ma. Soledad

doi:10.1007/s10096-019-03702-z

Cited by 14 publications

(20 citation statements)

References 54 publications

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“…The studies that reported higher yeast prevalence [78,79] were based only on a small sample size (36 and 32 samples, respectively), while three of the studies with the highest number of clinical samples were based on PCR techniques and reported a prevalence of 19.66% [71], 22.62% [64] and 28.33% [80].…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…A total of seven workers [45,50,55,62,[80][81][82] used both paper points and hand files for sample collection. Only one of them [45] used cultural methods, thus the meta-analysis could not be performed, while six of them [50,55,62,[80][81][82] used PCR, and the resulting WMP was 15.6% (CI 95%: 5.8-25.4) (Fig 5). Thirteen studies only included teeth presenting periapical lesion, with a WMP of 5.4% (CI 95%: 2.2-8.6) for cultural studies [45,47,48,51,52,57,58,65,66,72] (Fig 6) and 18.7% (CI 95%: 2.9-34.5) for molecular studies [55,64,72,78] (Fig 7).…”

Section: Resultsmentioning

confidence: 99%

“…These accounted for a limited number of cases (146 samples, respectively from 66 children, 20 HIV positive and 60 diabetic patients). Interestingly, the diabetic patients presented with a high prevalence of C. albicans (38.3%) in the infected root canals [80].…”

Section: Discussionmentioning

confidence: 97%

“…The vast majority of the cases included in the review were from systemically healthy and immunocompetent adults, not undergoing antibiotic or antifungal therapy over 1-6 months prior to sampling. However, a minority of studies were in children [62], and some were in human immunodeficiency virus (HIV) infected [70], and diabetic subjects [80]. These accounted for a limited number of cases (146 samples, respectively from 66 children, 20 HIV positive and 60 diabetic patients).…”

Section: Discussionmentioning

confidence: 99%

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Fungal species in endodontic infections: A systematic review and meta-analysis

et al. 2021

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Fungal infections are common on oral mucosae, but their role in other oral sites is ill defined. Over the last few decades, numerous studies have reported the presence of fungi, particularly Candida species in endodontic infections, albeit in relatively small numbers in comparison to its predominant anaerobic bacteriome. Here, we review the fungal biome of primary and secondary endodontic infections, with particular reference to the prevalence and behavior of Candida species. Meta-analysis of the available data from a total of 39 studies fitting the inclusion criteria, indicate the overall weighted mean prevalence (WMP) of fungal species in endodontic infections to be 9.11% (from a cumulative total of 2003 samples), with 9.0% in primary (n = 1341), and 9.3% in secondary infections (n = 662). Nevertheless, WMP for fungi in primary and secondary infections which were 6.3% and 7.5% for culture-based studies, increased to 12.5% and 16.0% in molecular studies, respectively. The most prevalent fungal species was Candida spp. The high heterogeneity in the reported fungal prevalence suggests the need for standardized sampling, and speciation methods. The advent of the new molecular biological analytical platforms, such as the next generation sequencing (NGS), and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF), that enables identification and quantitation of a broad spectrum of hitherto unknown organisms in endodontic infections should radically alter our understanding of the endodontic mycobiome in the future. Candida spp. appear to be co-pathogens with bacteria in approximately one in ten patients with endodontic infections. Hence, clinicians should comprehend the importance and the role of fungi in endodontic infections and be cognizant of the need to eradicate both bacteria and fungi for successful therapy.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Fungal species in endodontic infections: A systematic review and meta-analysis

et al. 2021

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Evolution of endodontic medicine: a critical narrative review of the interrelationship between endodontics and systemic pathological conditions

et al. 2021

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Endodontics has gained emphasis in the scientific community in recent years due to the increase in clinical and in animal models studies focused on endodontic medicine, which aims to evaluate the interrelationship between systemic and periapical tissues pathological conditions. These studies have shown that systemic changes can boost the pathogenesis of endodontic infection, favoring its development and progression. A contrary relationship is reported in numerous studies that affirm the potential of endodontic infection to trigger systemic damage and may lead to the worsening of pre-existing pathologies. Recently, the potential of filling materials to develop systemic changes such as neurological alterations had been evaluated, also showing that systemic diseases can negatively influence tissue responses to filling materials after endodontic treatment. Despite advances in endodontic medicine studies, there are still gaps in knowledge on the mechanisms of interactions between apical periodontitis (AP) and systemic diseases and much research to be done. In this sense, this critical narrative literature review aimed to show the evolution of studies in endodontic medicine to help the endodontist to know the role of systemic diseases in the pathogenesis of AP and the possible interference in the repair of periapical tissues after endodontic treatment, as well as to evidence the systemic complications that can be triggered or aggravated in the presence of endodontic infection.

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