Prevalence of calcific aortic valve disease in the elderly and associated risk factors: a population-based study in a Mediterranean area

Ferreira‐González, Ignacio; Pinar-Sopena, Josep; Ribera, Aída; Marsal, Josep Ramón; Cascant, Purificación; González‐Alujas, Teresa; Evangelista, Arturo; Brotons, Carlos; Moral, Irene; Permanyer-Miralda, Gaietà; Garcı́a-Dorado, David; Tornos, Pilar

doi:10.1177/2047487312451238

Cited by 57 publications

(22 citation statements)

References 22 publications

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“…Diseases of heart valves and the ascending aorta, together with their surgical interventions, are associated with considerable morbidity and mortality, not least among older adults 1, 2, 3, 4, 5. Prevalences of these diseases are relatively high and increase with age 6.…”

Section: Introductionmentioning

confidence: 99%

Traditional Cardiovascular Risk Factors and Their Relation to Future Surgery for Valvular Heart Disease or Ascending Aortic Disease: A Case–Referent Study

Ljungberg

Johansson

Engström

et al. 2017

JAHA

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BackgroundRisk factors for developing heart valve and ascending aortic disease are based mainly on retrospective data. To elucidate these factors in a prospective manner, we have performed a nested case–referent study using data from large, population‐based surveys.Methods and ResultsA total of 777 patients operated for heart valve disease or disease of the ascending aorta had previously participated in population‐based health surveys in Northern Sweden. Median time (interquartile range) from survey to surgery was 10.5 (9.0) years. Primary indications for surgery were aortic stenosis (41%), aortic regurgitation (12%), mitral regurgitation (23%), and dilatation/dissection of the ascending aorta (17%). For each case, referents were allocated, matched for age, sex, and geographical area. In multivariable models, surgery for aortic stenosis was predicted by hypertension, high cholesterol levels, diabetes mellitus, and active smoking. Surgery for aortic regurgitation was associated with a low cholesterol level, whereas a high cholesterol level predicted surgery for mitral regurgitation. Hypertension, blood pressure, and previous smoking predicted surgery for disease of the ascending aorta whereas diabetes mellitus was associated with reduced risk. After exclusion of cases with coronary atherosclerosis, only the inverse associations between cholesterol and aortic regurgitation and between diabetes mellitus and disease of the ascending aorta remained.ConclusionsThis is the first truly prospective study of traditional cardiovascular risk factors and their association with valvular heart disease and disease of the ascending aorta. We confirm the strong association between traditional risk factors and aortic stenosis, but only in patients with concomitant coronary artery disease. In isolated valvular heart disease, the impact of traditional risk factors is varying.

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Section: Introductionmentioning

confidence: 99%

Traditional Cardiovascular Risk Factors and Their Relation to Future Surgery for Valvular Heart Disease or Ascending Aortic Disease: A Case–Referent Study

Ljungberg

Johansson

Engström

et al. 2017

JAHA

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“…The prevalence rates of VHD in Uygur was significantly lower than that in Han and Kazak population. Prior studies have demonstrated that the pathology of calcific aortic valve disease involve chronic inflammation, lipids deposition, and calcium metabolism, all of which may differ between race-ethnic groups [22,23]. Yukiko Sashida performed a large multi-ethnic population-based cohort study to evaluate whether aortic valve thickness differs from race-ethnicity.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of valvular heart diseases and associated risk factors in Han, Uygur and Kazak population in Xinjiang, China

et al. 2017

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BackgroundValvular heart diseases (VHD) is very common in clinical practice and has became the subject of growing attention in the field of cardiovascular medicine. Our aim was to assess the prevalence and correlates of VHD in the general population in Xinjiang, China.MethodsUsing a 4-stage stratified cluster random sampling method, a total of 14618 participants were recruited in the Cardiovascular Risk Survey (CRS) study. The participants’ personal information, medical history were assessed by questionnaire. VHD was diagnosed by transthoracic echocardiography. We carried out the statistical analysis utilizing SPSS Statistics version 19.0.ResultsIn the total study group, VHD was observed in 1397 (9.65%) individuals. The prevalence rates of VHD in Han, Uygur and Kazak group are 13.51%, 2.71% and 12.29% respectively. The prevalence rates of VHD increased strikingly with age (all P < 0.001). The results of multinomial regression analysis indicated that VHD were related to age in Han group, to age smoking and hypertension in Uygur group, to age and hypertension in Kazak group.ConclusionOur research provides a unique prevalence rate of VHD in Xinjiang natural population. The result suggests that VHD are notably common in this population (9.65%) and increase with age. There exists significant difference of prevalence rate between ethnics. The main risk factors of VHD are age, hypertension and smoking. Valvular heart diseases should be regarded as a serious and growing public-health problem.

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“…The aortic valve disease increases its prevalence with age. Being 3% in the population of major or equal to 65 years old and more than 7.4% in those over 85 years old [1] it is a real challenge for the health community system. Traditionally the conventional approach to the aortic valve replacement has been the full sternotomy.…”

Section: Editorialmentioning

confidence: 99%

Minimally Invasive Aortic Valve Replacement: Is It Now the Best Surgical Approach?

Reyes

Calle

2016

Journal of Cardiology and Therapy

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Full sternotomy aortic valve replacement has been the gold standard for the treatment of severe aortic stenosis. Now transcatheter aortic valve implantation is becoming a new procedure that has shown its efficacy in a high risk population with aortic stenosis. Minimally invasive aortic valve replacement, using a 7-9 centimeters incision with an upper sternotomy tries to obtain the advantages and open surgical field and the less aggression of transcatheter procedures. We review the pros and cons of the minimally invasive aortic valve replacement updating the information obtained in the literature.

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Prevalence of calcific aortic valve disease in the elderly and associated risk factors: a population-based study in a Mediterranean area

Abstract: The prevalence of ASC and AS in people ≥65 years is similar to that reported in other regions. The gradient in the association of cardiovascular risk factors with the severity of ASC suggests that they may be causally implied in the pathogenesis of the disease.

Cited by 57 publications

References 22 publications

Traditional Cardiovascular Risk Factors and Their Relation to Future Surgery for Valvular Heart Disease or Ascending Aortic Disease: A Case–Referent Study

Traditional Cardiovascular Risk Factors and Their Relation to Future Surgery for Valvular Heart Disease or Ascending Aortic Disease: A Case–Referent Study

Prevalence of valvular heart diseases and associated risk factors in Han, Uygur and Kazak population in Xinjiang, China

Minimally Invasive Aortic Valve Replacement: Is It Now the Best Surgical Approach?

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