Prevalence of CagA and VacA Antibodies in Children with
            <i>Helicobacter pylori</i>
            -Associated Peptic Ulcer Compared to Prevalence in Pediatric Patients with Active or Nonactive Chronic Gastritis

Alarcón, Teresa; Martínez, María Josefa García; Urruzuno, Pedro; Cilleruelo, María Luz; Madruga, D.; Sebastián, M; Domingo, Diego; Sanz, Juan Carlos; López-Brea, M

doi:10.1128/cdli.7.5.842-844.2000

Cited by 10 publications

(8 citation statements)

References 17 publications

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“…In the present study, the detection of such antibodies in the sera of symptomatic and asymptomatic subjects indicates that CagApositive H pylori strains prevailed in both groups. These results appeared to be in agreement with those of previously published reports (4,(15)(16)(17)27,30). Rocha et al (23) indicated that immunoblotting using the Helico-Blot kit is useful for the diagnosis of H pylori infection in children and that the frequency of immunoreactive bands to CagA antigen is higher in children with duodenal ulcer than in children without the disease.…”

Section: Discussionsupporting

confidence: 91%

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Helicobacter pyloriAnti-CagA Antibodies: Prevalence in Symptomatic and Asymptomatic Subjects in Turkey

Abasıyanık

Sander²,

Salih

2002

Canadian Journal of Gastroenterology

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Section: Discussionsupporting

confidence: 91%

“…H pylori is associated with several gastroduodenal diseases such as gastritis, gastric ulcer, duodenal ulcer, gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma (2,26,27). CagA has been associated with the development of peptic ulcer disease and gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pyloriAnti-CagA Antibodies: Prevalence in Symptomatic and Asymptomatic Subjects in Turkey

Abasıyanık

Sander²,

Salih

2002

Canadian Journal of Gastroenterology

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“…The majority of our H. pylori ‐seropositive DU (12/18) and gastritis patients (32/48) were infected with CagA positive H. pylori strain. An association between CagA+ H. pylori strains and the presence of gastritis and gastric or duodenal ulcer was previously reported [26–30], as well as inconsistent results [31–33]. Kato et al [31] found that a high prevalence of CagA+ H. pylori strains in children was not associated with peptic ulcer disease.…”

Section: Discussionmentioning

confidence: 87%

The humoral immuneresponse toHelicobacter pyloriinfection in children with gastrointestinal symptoms

Janulaitytė-Gunther¹,

Kučinskienė²,

Kupčinskas³

et al. 2005

FEMS Immunology &Amp; Medical Microbiology

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The prevalence of Helicobacter pylori is high in Eastern Europe. The purpose of this study was to estimate the prevalence of H. pylori in symptomatic Lithuanian children and to identify the infection by clinicopathological and serological analyses. One hundred sixteen symptomatic children (age 8-16) with gastritis and duodenal ulcer were included. Biopsies were histologically assessed according to the Sydney-System. Serum IgG antibodies against H. pylori were detected by an enzyme-linked immunosorbent assay (ELISA), using low molecular mass antigen. The western blot technique was used to detect serum antibodies against the cytotoxin-associated protein (CagA) using whole cell antigen. Histologically the prevalence of H. pylori infection was 79% and not influenced by demographic factors. Mucosal inflammation and atrophy were associated with a H. pylori infection. Intestinal metaplasia was found in eight children, suggesting early H. pylori acquisition in life. Increased levels of IgG antibodies were detected in 57% of children. The prevalence of IgG antibodies was significantly higher in patients with duodenal ulcer compared to children with gastritis. Forty-four (67%) H. pylori-seropositive children had antibodies against CagA. Low molecular weight-ELISA and whole cell-western blot results were significantly associated with histopathology, the presence of duodenal ulcer and the CagA status. A high number of false seronegative cases were due to poor immunological responses in children and poor locally validated tests. The prevalence of H. pylori infection in Lithuanian children is higher compared to Western Europe. The infection is acquired in early life. Diagnosing H. pylori infection, serology is helpful, but endoscopy/histology remains as gold standard.

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“…Although an association between cagA þ H. pylori strains and the presence of severe gastritis and gastric or duodenal ulcer has previously been reported [3^6, 9,10], inconsistent results have also been reported [7,11,12].…”

Section: Discussionmentioning

confidence: 99%

ThecagAstatus ofHelicobacter pyloriisolates from dyspeptic children in Turkey

Demır

Engin

Ertunç³

et al. 2003

FEMS Immunology &Amp; Medical Microbiology

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There are inconsistent reports regarding cytotoxin-associated gene A (cagA) status of Helicobacter pylori isolates and the severity of the mucosal lesions in children. The aim of this study was to determine the prevalence of cagA(+) strains and to evaluate its correlation with clinic and endoscopic findings. We examined 45 H. pylori strains that were grown on brain-heart infusion agar supplemented with 7% horse blood. Following 72 h of incubation colonies were harvested and bacterial DNA was extracted. Polymerase chain reaction primers F1 and B1 were used to amplify a 348-bp internal fragment of cagA. The prevalence of cagA in Turkish pediatric patients was 55.6%. No association was found between cagA status and the severity of gastro-duodenal lesions.

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Prevalence of CagA and VacA Antibodies in Children with Helicobacter pylori -Associated Peptic Ulcer Compared to Prevalence in Pediatric Patients with Active or Nonactive Chronic Gastritis

Cited by 10 publications

References 17 publications

Helicobacter pyloriAnti-CagA Antibodies: Prevalence in Symptomatic and Asymptomatic Subjects in Turkey

Helicobacter pyloriAnti-CagA Antibodies: Prevalence in Symptomatic and Asymptomatic Subjects in Turkey

The humoral immuneresponse toHelicobacter pyloriinfection in children with gastrointestinal symptoms

ThecagAstatus ofHelicobacter pyloriisolates from dyspeptic children in Turkey

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