Prevalence of cagA and babA2 positive Helicobacter pylori strains in dyspeptic patients in Iran

Abstract

Background: Helicobacter pylori genome encodes a large number of virulence and adhesion factors that involved in bacterial adhesion to host cells and exerts its virulence effect with CagA secretion. In this study, we aimed to examine the relationships between babA2 and cagA genotype and presence of gastric disorders in patients from Iran. Material and Methods: The presence of H. pylori and selected genes (cagA and babA2) were detected by PCR method from the genomic DNA of 105 patients who had been diagnosed with gastric disorders like chronic gastritis by endoscopic and histopathologic routes. Results: Presence of H. pylori (glmM gene) was detected in 85 out of 105 (80.9%) patients. According to our results cagA gene was found in 66 out of 85 (77.6%) patients and babA2 gene was found in 80 out of 85 (94.1%) patient. Conclusion: In conclusion, the cagA and babA2 genotypes might be considered as useful biomarkers for non-ulcer disease (NUD) patients and gastric disorders in the geographic region of Iran and the presence of H. pylori strains with double-positive status is high clinical relevance to H. pylori-associated diseases.