Prevalence of bronchoconstriction induced by eucapnic voluntary hyperpnoea in recreationally active individuals

Molphy, John; Dickinson, John W.; Hu, Jie; Chester, Neil; Whyte, Greg

doi:10.3109/02770903.2013.838256

Cited by 26 publications

(25 citation statements)

References 28 publications

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“…≥10% fall in FEV1) was 17% and similar to previous work in a comparable population (>13%) (17). Similarly, when employing a previously published IOS cut-off value (i.e.…”

Section: Discussionsupporting

confidence: 88%

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The role of impulse oscillometry in detecting airway dysfunction in athletes

Price¹,

Ansley²,

Bikov³

et al. 2015

Journal of Asthma

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“…≥10% fall in FEV1) was 17% and similar to previous work in a comparable population (>13%) (17). Similarly, when employing a previously published IOS cut-off value (i.e.…”

Section: Discussionsupporting

confidence: 88%

“…A modified version of EVH was performed based on the protocol described previously (17,22). Briefly, subjects breathed a dry compressed gas mixture (21% O2, 5% CO2, balance N2) at a target ventilation rate equivalent to 85% (baseline FEV1 * 30) of their predicted maximal voluntary ventilation (MVV) for 6 min.…”

Section: Eucapnic Voluntary Hyperpnoea Challengementioning

confidence: 99%

The role of impulse oscillometry in detecting airway dysfunction in athletes

Price¹,

Ansley²,

Bikov³

et al. 2015

Journal of Asthma

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“…In a significant number of athletes, respiratory symptoms may arise from local release of inflammatory mediators (such as prostaglandins or leukotrienes) after dehydration of the airway surface lining in response to exercise hyperpnea and from ensuing narrowing of the airways (3). High prevalence of exercise-induced bronchoconstriction (EIB) has been reported in regular exercisers (21,23) and elite athletes (9). In approximately half of athletes, however, EIB does not explain the occurrence of symptoms (31).…”

mentioning

confidence: 99%

Self-reported Symptoms after Induced and Inhibited Bronchoconstriction in Athletes

Simpson

Romer²,

Kippelen³

2015

Medicine &Amp; Science in Sports &Amp; Exercise

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PurposeA change in the perception of respiratory symptoms after treatment with inhaled beta2 agonists is often used to aid diagnosis of exercise-induced bronchoconstriction (EIB). Our aim was to test the association between subjective ratings of respiratory symptoms and changes in airway caliber after induced and inhibited bronchoconstriction in athletes with EIB.MethodsEighty-five athletes with diagnosed or suspected EIB performed a eucapnic voluntary hyperpnea (EVH) challenge with dry air. Of the 45 athletes with hyperpnea-induced bronchoconstriction [i.e., post-EVH fall in forced expiratory volume in 1 s (FEV1) ≥10%, EVH−], 36 were randomized in a double-blind, placebo-controlled, crossover study. Terbutaline (0.5 mg) or placebo was administered by inhalation 15 min before EVH. Spirometry (for FEV1) was performed before and after EVH, and respiratory symptoms were recorded 15 min after EVH on visual analog scales.ResultsTerbutaline inhibited bronchoconstriction (i.e., maximal fall in FEV1 <10% after EVH) in 83% of the EVH-positive athletes, with an average degree of bronchoprotection of 53% (95% confidence interval [CI], 45% to 62%). Terbutaline reduced group mean symptom scores (P < 0.01), but the degree of bronchoprotection did not correlate with individual differences in symptom scores between terbutaline and placebo. Of the 29 athletes who had less than 10% FEV1 fall after EVH in the terbutaline condition, almost half (48%) rated at least one respiratory symptom higher under terbutaline, and more than one quarter (28%) had a higher total symptom score under terbutaline.ConclusionSelf-reports of respiratory symptoms in conditions of induced and inhibited bronchoconstriction do not correlate with changes in airway caliber in athletes with EIB. Therefore, subjective ratings of respiratory symptoms after treatment with inhaled beta2 agonists should not be used as the sole diagnostic tool for EIB in athletes.

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“…17,18 The EVH test can be tightly controlled, has high specificity and sensitivity for diagnosing EIB, and results in fewer false-negative diagnoses compared with exercise challenges. 15,[19][20][21] It is therefore considered a superior bronchoprovocation challenge for identifying EIB. 15,22 The clinical utility of the EVH test critically depends on the extent to which it elicits a reproducible day-to-day fall in FEV 1 .…”

Section: Introductionmentioning

confidence: 99%