Prevalence of Borna Disease Virus Antibodies in Healthy Japanese Black Cattle in Kyushu

Watanabe, Yohei; Yanai, Hideyuki; Ohtaki, Naohiro; Ikuta, Kazuyoshi; Tomonaga, Keizō

doi:10.1292/jvms.68.171

Cited by 8 publications

(5 citation statements)

References 30 publications

(38 reference statements)

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“…However, the conflicting results regarding BDV infection cannot be attributed only to geographic factors. It has been reported that BDV is not associated with psychiatric patients in Kyushu island in Japan, a known endemic area of BDV infection 8,42,49. However, there have been two BDV-positive reports in Brazil, which has not been known to be an endemic BDV infection area 23,24.…”

Section: Discussionmentioning

confidence: 97%

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Failure to Detect Borna Disease Virus Antibody and RNA from Peripheral Blood Mononuclear Cells of Psychiatric Patients

Lee

Tae

Song

et al. 2009

Psychiatry Investig

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ObjectiveBorna disease virus (BDV) is a highly neurotropic agent causing various neuropsychiatric symptoms in animals. Over the past two decades, it has been suggested that BDV might be associated with human psychiatric diseases. We aimed to investigate whether BDV is associated with psychiatric patients in Korea.MethodsWe recruited 60 normal controls and 198 psychiatric patients (98 patients with depressive disorder, 60 with schizophrenia, and 40 with bipolar disorder). We used an indirect immunofluorescence antibody (IFA) test for the BDV antibody and a real-time reverse transcriptase polymerase chain reaction (rRT-PCR) assay for p24 and p40 RNA from peripheral blood mononuclear cells (PBMCs).ResultsNeither the BDV antibody nor p24, p40 RNA was detected in controls and patients groups.ConclusionOur results suggest that BDV might not be associated with psychiatric patients in Korea.

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Section: Discussionmentioning

confidence: 97%

“…BDV is a highly neurotropic RNA virus with an enveloped, nonsegmented, negative stranded RNA genome 2-4. BDV has been known to naturally infect several animal species such as cattle, cats, horses, and sheep 5-8…”

Section: Introductionmentioning

confidence: 99%

Failure to Detect Borna Disease Virus Antibody and RNA from Peripheral Blood Mononuclear Cells of Psychiatric Patients

Lee

Tae

Song

et al. 2009

Psychiatry Investig

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“…As we used the same primers as in the previous report [31], the lack of BoDV-1 detection in this study should not be due to the sensitivity of PCR, or due to the sampling site, since serologically positive cases and detection of BoDV-1 genome fragment in mammals have been reported for the same sampling sites in Japan [33,34]. Together with the fact that there have been only a few reports of BoDV-1 detected in birds in the last several decades [30,31], our data suggest that the possibility of BoDV-1 infection in birds is rare, at least at our sampling sites in Japan.…”

Section: Discussionmentioning

confidence: 86%

Parrot bornavirus-2 and -4 RNA detected in wild bird samples in Japan are phylogenetically adjacent to those found in pet birds in Japan

Sassa

Bui

Saitoh³

et al. 2015

Virus Genes

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Bornaviruses (family Bornaviridae) are non-segmented negative-strand RNA viruses. Avian bornaviruses (ABVs), which are causative agents of proventricular dilatation disease, are a genetically diverse group with at least 15 genotypes, including parrot bornaviruses (PaBVs) and aquatic bird bornavirus 1(ABBV-1). Borna disease virus 1(BoDV-1), which infects mammals and causes neurological diseases, has also been reported to infect avian species, although the numbers of the cases have been markedly fewer than those of ABVs. In this study, we conducted genetic surveillance to detect ABVs (PaBV-1 to -5 and ABBV-1) and BoDV-1 in wild birds in Japan. A total of 2078 fecal or cloacal swab samples were collected from wild birds in 2006, 2007, 2008, and 2011, in two regions of Japan. The results demonstrated the presence of PaBV-2 and -4 RNA, while no positive results for other PaBVs, ABBV-1, and BoDV-1 were obtained. PaBV-2 and -4 RNA were detected in 18 samples (0.9 %) of the genera Anas, Grus, Larus, Calidris, Haliaeetus, and Emberiza, in which either PaBV-2 RNA or PaBV-4 RNA, or both PaBV-2 and -4 RNA were detected in 15 (0.7 %), 5 (0.2 %), and 2 (0.1 %) samples, respectively. The nucleotide sequences of PaBV-2 and -4 detected in these samples from wild birds are phylogenetically close to those found in samples from pet birds in Japan, with identities ranging from 99.8 to 100 % and from 98.2 to 99.4 %, respectively. To the best of our knowledge, this is the first report on the detection of PaBV-2 and -4 RNA detected in samples from wild birds.

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“…Symptoms other than encephalitis, such as infertility or astasia, has been confirmed in antibody-positive cows [1]. Borna disease in both domestic animals and companion animals has been reported in Japan [3,4,5, 7, 8, 13,14,15, 25]; however, epidemiological studies of cattle are lacking. There are few studies on the mode of transmission of this virus in cattle, and many questions remain surrounding infection.…”

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confidence: 99%

Sero-epidemiological analysis of vertical transmission relative risk of Borna disease virus infection in dairy herds

Ando

Takino

Makita

et al. 2016

The Journal of Veterinary Medical Science

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Borna disease virus (BDV) is a virus that causes a neurological disease in domestic animals, including a variety of animal species in Japan. Few studies have examined the mode of transmission of this virus in cattle, and the exact mechanisms underlying the transmission of the virus need to be elucidated. This study aimed to examine the contribution of vertical transmission of the virus, which occurs when the virus is transmitted from the mother to offspring during gestation or birth. We used an epidemiological approach. The relative risk (RR) was calculated for cattle born to BDV sero-positive cows from farms with a higher within-herd prevalence of BDV (56.8%). We tested the sera of 1,122 dairy cattle from 24 dairy herds in Hokkaido Prefecture, Japan, for BDV infection using the ELISA and western blotting method. The overall level of BDV sero-prevalence was 22.1%. Seroprevalence was significantly higher in closed-breeding herds that do not have buying in cows (39.7%) than in farms that restock cattle by buying in cows (4.4%, P<0.01). The overall RR of BDV vertical transmission from infected mothers to their daughters was 1.86 (95% confidence interval (CI): 1.54–2.56). Our results show that vertical transmission contributes significantly to BDV transmission in the farms tested in this study.

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Prevalence of Borna Disease Virus Antibodies in Healthy Japanese Black Cattle in Kyushu

Cited by 8 publications

References 30 publications

Failure to Detect Borna Disease Virus Antibody and RNA from Peripheral Blood Mononuclear Cells of Psychiatric Patients

Failure to Detect Borna Disease Virus Antibody and RNA from Peripheral Blood Mononuclear Cells of Psychiatric Patients

Parrot bornavirus-2 and -4 RNA detected in wild bird samples in Japan are phylogenetically adjacent to those found in pet birds in Japan

Sero-epidemiological analysis of vertical transmission relative risk of Borna disease virus infection in dairy herds

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