Prevalence of Beta-Cell, Thyroid and Celiac Autoimmunity in North Indian Children with Recent Onset Type 1 Diabetes (T1D)

Dayal, Devi; Samprati, Madhusudan; Kaur, Neeraj; Minz, Ranjana Walker; Jayaraman, Dhaarani

doi:10.7860/jcdr/2015/11960.5711

Cited by 12 publications

(17 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[23] When the latter method is applied to small numbers of patients as in the present study, it may limit the applicability of the findings. [2] The threshold limits used in the current study are lower than those used in the previous Indian studies[23] which may have contributed to a higher frequency of GAD65 autoantibodies. It is thus important to mention how the thresholds for GAD65 autoantibodies were determined.…”

mentioning

confidence: 99%

Prevalence of islet autoantibodies in type 1 diabetes

Dayal

Hegde

2017

Indian J Endocr Metab

Self Cite

View full text Add to dashboard Cite

mentioning

confidence: 99%

Prevalence of islet autoantibodies in type 1 diabetes

Dayal

Hegde

2017

Indian J Endocr Metab

Self Cite

View full text Add to dashboard Cite

“…16,17 Several studies from India also have studied occurrence of anti TPO antibodies in T1DM pat ients (Table 2). [20][21][22][23][24] Prevalence of autoantibodies in these studies was 18.7%-59%. [20][21][22][23][24] The authors 22 have previously reported a prevalence of 41% of patients with T1DM being positive for anti TPO antibodies.…”

Section: Autoimmune Thyroid Diseasementioning

confidence: 99%

“…[20][21][22][23][24] Prevalence of autoantibodies in these studies was 18.7%-59%. [20][21][22][23][24] The authors 22 have previously reported a prevalence of 41% of patients with T1DM being positive for anti TPO antibodies. It was noted that patients with goitre were more likely to have anti TPO antibodies.…”

Section: Autoimmune Thyroid Diseasementioning

confidence: 99%

“…12 The prevalence of anti-thyroid antibodies in patients with T1DM is shown in Tables 1 5,[13][14][15][16][17][18][19] and 2. [20][21][22][23][24] In a multicenter survey 25 done in Germany and Austria that included 17,749 patients with type 1 diabetes, aged 0.1-20 years, antibodies were measured and documented at least once in 7,097 patients. Elevated titres of thyroid autoantibodies (anti TPO and anti TG antibodies) were found in 21.6% of patients.…”

Section: Autoimmune Thyroid Diseasementioning

confidence: 99%

“…5,[32][33] In India, prevalence of celiac autoimmunity was reported to be 8%-22% among patients with established T1DM (Table 4). 24,[35][36][37][38][39][40] A two year follow-up study 41 was done at Barbara Davis Center for Childhood Diabetes to determine the impact of screening-detected celiac disease autoimmunity via IgA anti TTG antibodies in children with T1DM and GFD on growth, bone mineralization, and glycaemic control. It was found that anti TTG antibody positive subjects had consistently lower weight z-scores and higher urine N-telopeptides (a marker of bone turnover) than anti TTG antibody negative subjects, but had similar measures of bone densit y and diabet es outcomes.…”

Section: Coeliac Diseasementioning

confidence: 99%

See 2 more Smart Citations

Organ specific autoimmune disorders in type 1 diabetes mellitus

Ashok¹,

Sachan²

2017

jcsr

View full text Add to dashboard Cite

Type 1 Diabetes Mellitus (T1DM) is an autoimmune disease that results in absolute insulin deficiency due to destruction of the pancreatic beta cells. It is frequently associated with other autoimmune diseases like autoimmune thyroid (AIT) disease, celiac disease (CD), Addison's disease (AD), and vitiligo. These diseases, including T1DM are associated with organ specific autoantibodies. These autoantibodies are important as diagnostic markers and detectable antibodies may precede the clinical onset of the disease. These diseases usually occur together in same patient and have shared genetic predisposition. These autoimmune diseases can severely affect clinical management of T1DM. It is possible to screen for these associated diseases by testing for relevant autoantibodies. Earlier detection of organ specific autoimmunity will enable physicians to treat these diseases at an initial stage and can prevent development of fullblown clinical condition.

show abstract

Clinical features, biochemistry and HLA-DRB1 status in youth-onset type 1 diabetes in Pakistan

Fawwad

Govender

Ahmedani

et al. 2019

Diabetes Research and Clinical Practice

View full text Add to dashboard Cite

Published information on diabetes in Pakistani youth is limited. We aimed to investigate the demographic, clinical, and biochemical features, and HLA-DRB1 alleles in new cases of diabetes affecting children and adolescents <22 years of age. The study was conducted at Baqai Institute of Diabetology and Endocrinology in Karachi from June 2013-December 2015. One hundred subjects aged <22 years at diagnosis were enrolled. Demographic characteristics, clinical information, biochemical parameters (blood glucose, HbA1c, C-peptide, glutamic acid decarboxylase 65 (GAD65) and islet antigen 2 (IA-2) autoantibodies) were measured. DNA from 100 subjects and 200 controls was extracted and genotyped for HLA-DRB1 using high-resolution genotyping technology.

show abstract

Prevalence of Beta-Cell, Thyroid and Celiac Autoimmunity in North Indian Children with Recent Onset Type 1 Diabetes (T1D)

Cited by 12 publications

References 16 publications

Prevalence of islet autoantibodies in type 1 diabetes

Prevalence of islet autoantibodies in type 1 diabetes

Organ specific autoimmune disorders in type 1 diabetes mellitus

Clinical features, biochemistry and HLA-DRB1 status in youth-onset type 1 diabetes in Pakistan

Contact Info

Product

Resources

About