Prevalence of Barrett Esophagus in Adolescents and Young Adults With Esophageal Atresia

Schneider, Anne; Gottrand, Frédéric; Bellaïche, M.; Baudin, François; Lachaux, Alain; Bridoux-Henno, Laure; Michel, Jean‐Luc; Fauré, Christophe; Philippe, Paul; Vandenplas, Yvan; Dupont, Claire; Breton, A; Gaudin, J.; Lamireau, T.; Muyshont, Laurence; Podevin, Guillaume; Viola, S.; Bertrand, Valérie; Caldari, Dominique; Colinet, Stéphanie; Wanty, Catherine; Sauleau, Erik-André; Leteurtre, Emmanuelle; Michaud, Laurent

doi:10.1097/sla.0000000000001540

Cited by 37 publications

(7 citation statements)

References 34 publications

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“…The outcome of the surgical repair depends mainly on the type of the EA, with up to 50% of those with an associated tracheo-esophageal fistula suffering from GERD [ 31 ]. This tendency seems to increase with time [ 36 , 37 ]. Patients with EA are more likely to develop severe GERD due to multiple reasons: impaired anatomy with hiatus hernia or abnormal position of the intrathoracic part of esophagus, as well as due to complications arising from the vagal nerve injury (gastroparesis or delayed gastric emptying and esophageal motor activity dysfunction affecting esophageal acid clearance) [ 38 ].…”

Section: Clinical Presentation Of Gerd In the Pediatric Populationmentioning

confidence: 99%

Gastro-Esophageal Reflux in Children

Rybak

Pesce

Thapar

et al. 2017

IJMS

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Gastro-esophageal reflux (GER) is common in infants and children and has a varied clinical presentation: from infants with innocent regurgitation to infants and children with severe esophageal and extra-esophageal complications that define pathological gastro-esophageal reflux disease (GERD). Although the pathophysiology is similar to that of adults, symptoms of GERD in infants and children are often distinct from classic ones such as heartburn. The passage of gastric contents into the esophagus is a normal phenomenon occurring many times a day both in adults and children, but, in infants, several factors contribute to exacerbate this phenomenon, including a liquid milk-based diet, recumbent position and both structural and functional immaturity of the gastro-esophageal junction. This article focuses on the presentation, diagnosis and treatment of GERD that occurs in infants and children, based on available and current guidelines.

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Section: Clinical Presentation Of Gerd In the Pediatric Populationmentioning

confidence: 99%

Gastro-Esophageal Reflux in Children

Rybak

Pesce

Thapar

et al. 2017

IJMS

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“…In a recent retrospective study of 120 children with EA, there was 1 case of IM and 50 with GM [ 6 ]. In a second series of 209 children with EA, there were 4 with IM and 31 with GM.…”

Section: Discussionmentioning

confidence: 99%

Columnar Metaplasia of the Esophagus Presenting as Iron Deficiency Anemia in Children with Neurologic Impairment or Congenital Esophageal Atresia

et al. 2022

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Case series Patient: Female, 8-year-old • Male, 15-year-old • Male, 8-year-old • Male, 17-year-old • Male, 11-year-old Final Diagnosis: Columnar metaplasia of the esophagus Symptoms: Iron deficiency anemia Medication: — Clinical Procedure: Esophagogastroduodenoscooy Specialty: Gastroenterology and Hepatology Objective: Rare coexistence of disease or pathology Background: Columnar metaplasia of the lower esophagus includes both gastric and intestinal metaplasia. Children with severe neurologic impairment and congenital esophageal atresia often have gastroesophageal reflux disease, which can lead to Barrett’s esophagus, a form of lower esophageal columnar metaplasia and precursor to esophageal adenocarcinoma, with some, but not all, guidelines specifically requiring the presence of intestinal metaplasia for diagnosis. This case series illustrates how iron deficiency anemia may be the primary symptom of esophageal columnar metaplasia in such children and how upper endoscopy is essential in their initial and ongoing evaluation. Case Reports: We review 5 cases of columnar metaplasia of the lower esophagus in children, 3 with severe neurologic impairment and 2 with esophageal atresia. Each child presented with marked iron deficiency anemia and minimal-to-no gastrointestinal symptoms. Conclusions: We conclude that columnar metaplasia of the esophagus may present with iron deficiency anemia in children with neurologic impairment or congenital esophageal atresia, even if without overt gastrointestinal symptoms. Accordingly, we propose that early endoscopic evaluation should be considered in this specific patient population. Based on our literature review, we also emphasize the need for guidelines on the endoscopic surveil-lance of such children with any type of columnar metaplasia of the lower esophagus, given the associated risk of malignant transformation.

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“…A total of 830 patients were considered in the review. Table 1 [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] summarizes the patients' most important characteristics, as obtained from the analyzed articles.…”

Section: Descriptive Analysismentioning

confidence: 99%

Systematic review of long term follow-up and transitional care in adolescents and adults with esophageal atresia - why is transitional care mandatory?

et al. 2023

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Purpose: to review recent literature concerning long-term health issues and transitional care in esophageal atresia (EA) patients. PubMed, Scopus, Embase and Web of Science databases were screened for studies regarding EA patients aged more than or equal to 11 years, published between August 2014 and June 2022. Sixteen studies involving 830 patients were analyzed. Mean age was 27.4 years (range 11–63). EA subtype distribution was: type C (48.8%), A (9.5%), D (1.9%), E (0.5%) and B (0.2%). 55% underwent primary repair, 34.3% delayed repair, 10.5% esophageal substitution. Mean follow-up was 27.2 years (range 11–63). Long-term sequelae were: gastro-esophageal reflux (41.4%), dysphagia (27.6%), esophagitis (12.4%), Barrett esophagus (8.1%), anastomotic stricture (4.8%); persistent cough (8.7%), recurrent infections (4.3%) and chronic respiratory diseases (5.5%). Musculo-skeletal deformities were present in 36 out of 74 reported cases. Reduced weight and height were detected in 13.3% and 6% cases, respectively. Impaired quality of life was reported in 9% of patients; 9.6% had diagnosis or raised risk of mental disorders. 10.3% of adult patients had no care provider. Meta-analysis was conducted on 816 patients. Estimated prevalences are: GERD 42.4%, dysphagia 57.8%, Barrett esophagus 12.4%, respiratory diseases 33.3%, neurological sequelae 11.7%, underweight 19.6%. Heterogeneity was substantial (> 50%). Conclusion: EA patients must continue follow-up beyond childhood, with a defined transitional-care path by a highly specialized multidisciplinary team due to the multiple long-term sequelae. What is Known:• Survival rates of esophageal atresia patients is now more than 90% thanks to the improvements in surgical techniques and intensive care, therefore patients’ needs throughout adolescence and adulthood must be taken into account. What is New:• This review, by summarizing recent literature concerning long term sequelae of esophageal atresia, may contribute to raise awareness on the importance of defining standardized protocols of transitional and adulthood care for esophageal atresia patients.

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Prevalence of Barrett Esophagus in Adolescents and Young Adults With Esophageal Atresia

Cited by 37 publications

References 34 publications

Gastro-Esophageal Reflux in Children

Gastro-Esophageal Reflux in Children

Columnar Metaplasia of the Esophagus Presenting as Iron Deficiency Anemia in Children with Neurologic Impairment or Congenital Esophageal Atresia

Systematic review of long term follow-up and transitional care in adolescents and adults with esophageal atresia - why is transitional care mandatory?

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