Prevalence of Bacterial Uropathogens Among Diabetic Patients Attending Padma Nursing Hospital of Western Nepal

Shrestha, Pashupati; Koirala, Amrit; Khadka, Jagat; Gautam, Narayan; Rijal, Komal Raj

doi:10.3126/hijost.v1i0.25816

Cited by 13 publications

(16 citation statements)

References 6 publications

(6 reference statements)

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“…Similar findings were reported by Turan et al, (2008) and Chaudhary et al, (2017). Tamang et al, (2017) et al, 2009). Most of the UTI studies showed higher prevalence of gram negative bacteria than gram positive bacteria (Chaudhary et al, 2017;Tamang et al, 2017;Puri et al, 2006).…”

Section: Occurrence Of Bacteria In Different Age Groupssupporting

confidence: 90%

“…(Chhetri et al, 2011). Similar results were reported by Boyko et al, (2005); Lin et al, (2008); Paryani et al,(2012) and Tamang et al, (2017). Klebsiella species were second common uropathogens (7%) among postmenopausal women.…”

Section: Occurrence Of Bacteria In Different Age Groupssupporting

confidence: 87%

“…Tamang et al, (2017) et al, 2009). Most of the UTI studies showed higher prevalence of gram negative bacteria than gram positive bacteria (Chaudhary et al, 2017;Tamang et al, 2017;Puri et al, 2006). Shankel, 2007).…”

Section: Occurrence Of Bacteria In Different Age Groupsmentioning

confidence: 99%

“…The false negative results could be due to early urinary tract infection or presence of asymptomatic UTI patients, diabetes and enteric fever or bacterial endocarditis, whereas false positive results (pyruria with negative culture result) could be due to proper use of antibiotics by the patients or presence of bacteria which were unable to grow on the routine culture media (Tamang et al, 2017).…”

Section: Pyuria Verses Bacteriuria In Postmenopausal Womenmentioning

confidence: 99%

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Bacteriological Profile of Urinary Tract Infections among Postmenopausal Women Visiting Alka Hospital, Lalitpur, Nepal

Yadav

Dahal

Sah

et al. 2018

Himalayan J. Sci. Technol.

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Urinary tract infection (UTI) is one of the most common diseases encountered worldwide and is a major public health problem in terms of morbidity and financial costs. A cross-sectional study was conducted in Alka Hospital, Lalitpur, Nepal from February to July, 2014. A total of 353 midstream urine samples were collected from postmenopausal women visiting Alka Hospital, Lalitpur, Nepal. The samples were examined by microscopically and culture methods. The isolated organisms were identified by conventional microbiological methods. Antibiotic susceptibility test was performed by modified Kirby-Bauer disc diffusion method according to CLSI (2011) guidelines. Among 353 urine samples processed, 32 % (113) showed significant bacteriuria. Out of 113 bacterial isolates, the prevalence of gram negative bacteria was 97.3% (110) while that of gram positive was 2.7% (3). The most predominating organisms causing UTI were Escherichia coli (84.9%) followed by Klebsiella pneumoniae (5.3%), Enterococcus faecalis (1.7%), Providencia spp. (1.7%), Klebsiella oxytoca (1.7%), Proteus mirabilis (1.7%), Proteus vulgaris (0.9%), Citrobacter freundii (0.9%) and Staphylococcus aureus (0.9%). Antibiotic susceptibility tests of the isolates showed that, most of the gram negative bacterial isolates were sensitive to Piperacillin+Tazobactam followed by Amikacin, Imipenem and Nitrofurantoin, while they were resistant to Amoxicillin. All gram positive isolates were sensitive to Amoxicillin and resistant to Gentamycin. This study showed that higher aged postmenopausal women (>80 years) were at higher risk for UTI than those of lower aged ones (<80 years).

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Section: Occurrence Of Bacteria In Different Age Groupssupporting

confidence: 90%

Section: Occurrence Of Bacteria In Different Age Groupssupporting

confidence: 87%

Section: Occurrence Of Bacteria In Different Age Groupsmentioning

confidence: 99%

Section: Pyuria Verses Bacteriuria In Postmenopausal Womenmentioning

confidence: 99%

See 2 more Smart Citations

Bacteriological Profile of Urinary Tract Infections among Postmenopausal Women Visiting Alka Hospital, Lalitpur, Nepal

Yadav

Dahal

Sah

et al. 2018

Himalayan J. Sci. Technol.

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“…A similar pattern of antibiotic susceptibility was reported against uropathogenic E. coli isolates from the International Friendship Children's Hospital, Maharajgunj, Kathmandu, 42 Chitwan Medical College, Bharatpur, Chitwan, 43 and Padma Hospital, Pokhara, Nepal. 44 Klebsiella pneumoniae isolates were highly resistant to third generation cephalosporins (cefixime and ceftriaxone), which may be due to the production of extended-spectrum β-lactamase (ESBL). 45 AMR, including MDR, is a global issue.…”

Section: Discussionmentioning

confidence: 99%

Detection of OXA-48 Gene in Carbapenem-Resistant Escherichia coli and Klebsiella pneumoniae from Urine Samples

Gurung¹,

Kafle²,

Dhungel³

et al. 2020

IDR

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Introduction: Resistance to carbapenem in Gram-negative bacteria is attributable to their ability to produce carbapenemase enzymes. The main objective of this study was to detect the presence of blaOXA-48 genes in carbapenem-resistant uropathogenic Escherichia coli and Klebsiella pneumoniae isolated from urine samples from patients attending Alka Hospital, Jawalakhel, Lalitpur, Nepal. Methods: A total of 1013 mid-stream urine samples were collected from patients with suspected urinary tract infection (UTI) between April and September 2018. The identified isolates underwent antibiotic susceptibility testing using the modified Kirby-Bauer discdiffusion method. Phenotypic carbapenemase production was confirmed by the modified Hodge test, and the blaOXA-48 gene was detected using conventional polymerase chain reaction. Results: Out of 1013 urine samples, 15.2% (154/1013) had bacterial growth. Among the isolates, 91.5% (141/154) were Gram-negative bacteria, and E. coli was the most common bacterial isolate (62.9%; 97/154), followed by K. pneumoniae 15.6% (24/154). Among 121 bacterial isolates (97 E. coli isolates and 24 K. pneumoniae isolates), 70.3% (52/121) were multidrug-resistant E. coli and 29.7% (22/121) were multidrug-resistant K. pneumoniae. In addition, 9.1% (11/121) were carbapenem resistant (both imipenem and meropenem resistant). Development of multidrug resistance and development of carbapenem resistance were significantly associated (p<0.05). Of the 11 carbapenem-resistant isolates, only seven were carbapenemase producers; of these, 28.6% (2/7) were E. coli, 72.4% (5/7) were K. pneumoniae and 42.8% (3/7) had the blaOXA-48 gene. Of the three bacterial isolates with the blaOXA-48 gene, 33.3% (1/3) were E. coli and 66.7% (2/3) were K. pneumoniae. Conclusion: One in ten isolates of E. coli and K. pneumoniae were carbapenem resistant. Among carbapenem-resistant isolates, one-third of E. coli and two-thirds of K. pneumoniae had the blaOXA-48 gene. OXA-48 serves as a potential agent to map the distribution of resistance among clinical isolates.

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Phenotypic and molecular characterization of clinically isolated antibiotics-resistant S. aureus (MRSA), E. coli (ESBL) and Acinetobacter 1379 bacterial strains

Iram,

Sansi,

Puniya

et al. 2024

Braz J Microbiol

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Prevalence of Bacterial Uropathogens Among Diabetic Patients Attending Padma Nursing Hospital of Western Nepal

Cited by 13 publications

References 6 publications

Bacteriological Profile of Urinary Tract Infections among Postmenopausal Women Visiting Alka Hospital, Lalitpur, Nepal

Bacteriological Profile of Urinary Tract Infections among Postmenopausal Women Visiting Alka Hospital, Lalitpur, Nepal

<p>Detection of OXA-48 Gene in Carbapenem-Resistant <em>Escherichia coli</em> and <em>Klebsiella pneumoniae</em> from Urine Samples</p>

Phenotypic and molecular characterization of clinically isolated antibiotics-resistant S. aureus (MRSA), E. coli (ESBL) and Acinetobacter 1379 bacterial strains

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