Prevalence of Autoimmune Disease in Patients with Eosinophilic Esophagitis: A Cross-sectional Study of Three Hospitals in Japan

Ayaki, Maki; Manabe, Noriaki; Fujita, Minoru; Katsumata, Ryo; Nakamura, Jun; Kamada, Takenobu; Murota, Makiko; Inoue, Kentaro; Haruma, Ken

doi:10.2169/internalmedicine.7389-21

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…Notably, the differences arise from different gut microbiota, hormonal factors, and to a lesser extent from autoimmune variations [ 61 ]. Interestingly, higher rates of comorbid celiac disease, Crohn’s disease, or ulcerative colitis are found in patients with eosinophilic esophagitis than in the general population [ 63 ].…”

Section: Resultsmentioning

confidence: 99%

Autoimmune Disease Classification Based on PubMed Text Mining

Samuels

Malov

Saha

et al. 2022

JCM

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Autoimmune diseases (AIDs) are often co-associated, and about 25% of patients with one AID tend to develop other comorbid AIDs. Here, we employ the power of datamining to predict the comorbidity of AIDs based on their normalized co-citation in PubMed. First, we validate our technique in a test dataset using earlier-reported comorbidities of seven knowns AIDs. Notably, the prediction correlates well with comorbidity (R = 0.91) and validates our methodology. Then, we predict the association of 100 AIDs and classify them using principal component analysis. Our results are helpful in classifying AIDs into one of the following systems: (1) gastrointestinal, (2) neuronal, (3) eye, (4) cutaneous, (5) musculoskeletal, (6) kidneys and lungs, (7) cardiovascular, (8) hematopoietic, (9) endocrine, and (10) multiple. Our classification agrees with experimentally based taxonomy and ranks AID according to affected systems and gender. Some AIDs are unclassified and do not associate well with other AIDs. Interestingly, Alzheimer’s disease correlates well with other AIDs such as multiple sclerosis. Finally, our results generate a network classification of autoimmune diseases based on PubMed text mining and help map this medical universe. Our results are expected to assist healthcare workers in diagnosing comorbidity in patients with an autoimmune disease, and to help researchers in identifying common genetic, environmental, and autoimmune mechanisms.

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Section: Resultsmentioning

confidence: 99%

Autoimmune Disease Classification Based on PubMed Text Mining

Samuels

Malov

Saha

et al. 2022

JCM

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“… 29 Similarly, there seems to be an elevated risk of multiple autoimmune disorders among individuals with EoE. 30 , 31 Apart from a positive association with CeD, a 2016 US study found associations of EoE with Crohn disease, ulcerative colitis, and Hashimoto thyroiditis. 31 Our research group, however, recently reported a positive association of EoE with only Crohn disease.…”

Section: Discussionmentioning

confidence: 99%

Association of celiac disease with eosinophilic esophagitis: Nationwide register-based cohort study with sibling analyses

Mitselou,

Uchida,

Roelstraete

et al. 2024

Journal of Allergy and Clinical Immunology: Global

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Association of eosinophilic esophagitis with autoimmune and connective tissue disorders, and the impact on treatment response

Xue

Miller²,

Abramson

et al. 2022

Diseases of the Esophagus

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Eosinophilic esophagitis (EoE) has been associated with autoimmune (AI) and connective tissue disorders (CTDs), but clinical correlates and treatment response to topical corticosteroids (tCS) for patients with both conditions are not well known. We aimed to determine the prevalence and clinical features of AI/CTDs in EoE patients, and assess the response to tCS. In this retrospective cohort study of adults and children newly diagnosed with EoE in the University of North Carolina EoE Clinicopathologic database, we extracted clinical characteristics and treatment response data. We compared EoE patients with and without AI/CTDs, identified independently associated factors, and explored treatment responses. Of 1029 EoE patients, 61 (5.9%) had an AI/CTDs. The most common AI/CTDs were psoriasis/psoriatic arthritis (P/PA) (1.7%), Hashimoto’s (1.2%), and rheumatoid arthritis (RA) (1%). Compared to those without AI/CTDs, AI/CTDs patients were older (35 vs. 28 years, P = 0.004), more likely to be female (51% vs. 30%, P = 0.001), have insurance (93% vs. 78%, P = 0.004) and a longer symptom duration prior to EoE diagnosis (10 vs. 7 years, P = 0.02). Older age, female sex, having insurance, and having allergic rhinitis were independently associated with AI/CTDs. AI/CTD patients with EoE were less likely to have a symptom response (47% vs. 79%, P = 0.003). Overlap between EoE and AI/CTDs was uncommon, seen in approximately 6%, with P/PA, Hashimoto’s, and RA being most frequent. In conclusion, older age, female sex, having insurance, and allergic rhinitis were independently associated with AI/CTDs. EoE patients with AI/CTDs had less symptom response, with trendtowards lower endoscopic and histologic responses, to tCS therapy.

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Prevalence of Autoimmune Disease in Patients with Eosinophilic Esophagitis: A Cross-sectional Study of Three Hospitals in Japan

Cited by 3 publications

References 36 publications

Autoimmune Disease Classification Based on PubMed Text Mining

Autoimmune Disease Classification Based on PubMed Text Mining

Association of celiac disease with eosinophilic esophagitis: Nationwide register-based cohort study with sibling analyses

Association of eosinophilic esophagitis with autoimmune and connective tissue disorders, and the impact on treatment response

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