Prevalence of autoimmune disease in women with premature ovarian failure

Grossmann, Benita; Saur, Sebastian; Rall, Katharina; Pecher, Ann-Christin; Hübner, Stephanie; Henes, Joerg; Henes, Melanie

doi:10.1080/13625187.2019.1702638

Cited by 50 publications

(27 citation statements)

References 12 publications

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“…The presence of increased TPOAb levels may identify women at risk for developing hypothyroidism after OS or during gestation and be a predictive marker for the development of post-partum thyroiditis [95]. Furthermore, women with PCOS, POI, and idiopathic subfertility have a higher prevalence of TAI and serum TSH levels compared with fertile women [6, 9, 25]. Serum TSH levels >3.5 mIU/L are associated with impaired ART outcomes, and LT4 treatment can increase LBRs in women with TSH levels >4.0 mIU/L [11, 14].…”

Section: Screening/management In Daily Practicementioning

confidence: 99%

“…TAI is the major cause of (subclinical) hypothyroidism in Europe and is more prevalent in women with idiopathic subfertility and polycystic ovarian syndrome (PCOS) than in fertile women [6, 7]. The prevalence of TAI is also higher in women with diminished ovarian reserve (DOR) and premature ovarian insufficiency [8, 9]. Furthermore, serum TSH levels are inversely correlated with the anti-Müllerian hormone, an accurate marker of the ovarian reserve [9].…”

Section: Introductionmentioning

confidence: 99%

“…The prevalence of TAI is also higher in women with diminished ovarian reserve (DOR) and premature ovarian insufficiency [8, 9]. Furthermore, serum TSH levels are inversely correlated with the anti-Müllerian hormone, an accurate marker of the ovarian reserve [9].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

2021 European Thyroid Association Guideline on Thyroid Disorders prior to and during Assisted Reproduction

Poppe¹,

Bisschop²,

Fugazzola³

et al. 2020

Eur Thyroid J

118

108

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Severe thyroid dysfunction may lead to menstrual disorders and subfertility. Fertility problems may persist even after restoring normal thyroid function, and then an assisted reproductive technology (ART) may be a solution. Prior to an ART treatment, ovarian stimulation is performed, leading to high oestradiol levels, which may lead to hypothyroidism in women with thyroid autoimmunity (TAI), necessitating levothyroxine (LT4) supplements before pregnancy. Moreover, women with the polycystic ovarian syndrome and idiopathic subfertility have a higher prevalence of TAI. Women with hypothyroidism treated with LT4 prior to ART should have a serum TSH level <2.5 mIU/L. Subfertile women with hyperthyroidism planning an ART procedure should be informed of the increased risk of maternal and foetal complications, and euthyroidism should be restored and maintained for several months prior to an ART treatment. Fertilisation rates and embryo quality may be impaired in women with TSH >4.0 mIU/L and improved with LT4 therapy. In meta-analyses that mainly included women with TSH levels >4.0 mIU/L, LT4 treatment increased live birth rates, but that was not the case in 2 recent interventional studies in euthyroid women with TAI. The importance of the increased use of intracytoplasmic sperm injection as a type of ART on pregnancy outcomes in women with TAI deserves more investigation. For all of the above reasons, women of subfertile couples should be screened routinely for the presence of thyroid disorders.

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Section: Screening/management In Daily Practicementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

2021 European Thyroid Association Guideline on Thyroid Disorders prior to and during Assisted Reproduction

Poppe¹,

Bisschop²,

Fugazzola³

et al. 2020

Eur Thyroid J

118

108

View full text Add to dashboard Cite

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“…e reduction of estrogen levels can also increase the incidence of osteoporosis, ischemic heart disease, autoimmune diseases, Alzheimer's disease, etc., as well as the risk of death, bringing many serious consequences [2][3][4]. e incidence of POF in patients over 40 years old is about 1% and over 30 years old is about 0.1% [1].…”

Section: Instructionmentioning

confidence: 99%

“…e exact etiologies of POF are still unclear, and most of them are believed to be related to iatrogenic factors, chromosomal/genetic defects, autoimmune diseases, infections, environmental factors, congenital enzyme deficiency, idiopathic factors, etc. [2,3,[5][6][7].…”

Section: Instructionmentioning

confidence: 99%

The Treatment of Complementary and Alternative Medicine on Premature Ovarian Failure

Lin

Jia

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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It has been confirmed by growing evidence that common hormone replacement therapy is associated with an increasing risk of causing cardiovascular disease and cancer, while complementary and alternative medicine (CAM) is gaining popularity and application in more and more patients with premature ovarian failure (POF). Although there is little data concerning the clinical safety and efficacy of CAM, the literature includes application studies on the phytoestrogen-rich herbal, acupuncture treatment and intervention therapy. This article reviews recent literature on CAM therapy for POF, aiming to provide theoretical support for clinical application.

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Celiac disease does not influence markers of ovarian reserve in adolescent girls

Comba

Yılmaz

et al. 2020

Arch Gynecol Obstet

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Prevalence of autoimmune disease in women with premature ovarian failure

Cited by 50 publications

References 12 publications

2021 European Thyroid Association Guideline on Thyroid Disorders prior to and during Assisted Reproduction

2021 European Thyroid Association Guideline on Thyroid Disorders prior to and during Assisted Reproduction

The Treatment of Complementary and Alternative Medicine on Premature Ovarian Failure

Celiac disease does not influence markers of ovarian reserve in adolescent girls

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