Prevalence of autoantibodies that bind to kidney tissues in cats and association risk with antibodies to feline viral rhinotracheitis, calicivirus, and panleukopenia

Songaksorn, Nisakorn; Petsophonsakul, Wilaiwan; Pringproa, Kidsadagon; Lampang, Kannika Na; Sthitmatee, Nattawooti; Srifawattana, Nuttawan; Piyarungsri, Kakanang; Thongkorn, Kriangkrai

doi:10.4142/jvs.2021.22.e38

Cited by 5 publications

(3 citation statements)

References 41 publications

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“…However, none of the cats developed notable renal inflammation, glomerular disease or urine abnormalities. Moreover, in 156 privately owned cats in Thailand, vaccinated animals did not have higher antibody levels against feline kidney extracts nor did they have antibodies binding to kidney tissue sections more frequently than unvaccinated cats, although the study did show a correlation between the presence of antibodies to vaccine antigens and feline kidney extracts [ 164 ]. Overall, there is insufficient evidence for a causal role of parenteral vaccination in the induction of renal disease and further studies are required.…”

Section: General Recommendations On Vaccine Type and Vaccination Prot...mentioning

confidence: 99%

Calicivirus Infection in Cats

Hofmann‐Lehmann

Hosie

Hartmann

et al. 2022

Viruses

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Feline calicivirus (FCV) is a common pathogen in domestic cats that is highly contagious, resistant to many disinfectants and demonstrates a high genetic variability. FCV infection can lead to serious or even fatal diseases. In this review, the European Advisory Board on Cat Diseases (ABCD), a scientifically independent board of experts in feline medicine from 11 European countries, presents the current knowledge of FCV infection and fills gaps with expert opinions. FCV infections are particularly problematic in multicat environments. FCV-infected cats often show painful erosions in the mouth and mild upper respiratory disease and, particularly in kittens, even fatal pneumonia. However, infection can be associated with chronic gingivostomatitis. Rarely, highly virulent FCV variants can induce severe systemic disease with epizootic spread and high mortality. FCV can best be detected by reverse-transcriptase PCR. However, a negative result does not rule out FCV infection and healthy cats can test positive. All cats should be vaccinated against FCV (core vaccine); however, vaccination protects cats from disease but not from infection. Considering the high variability of FCV, changing to different vaccine strain(s) may be of benefit if disease occurs in fully vaccinated cats. Infection-induced immunity is not life-long and does not protect against all strains; therefore, vaccination of cats that have recovered from caliciviral disease is recommended.

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Section: General Recommendations On Vaccine Type and Vaccination Prot...mentioning

confidence: 99%

Calicivirus Infection in Cats

Hofmann‐Lehmann

Hosie

Hartmann

et al. 2022

Viruses

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“…One study produced anti-cat kidney antibodies in rabbits [ 107 ] to examine serum samples and kidneys collected from 156 live and 26 cats at necropsy to evaluate whether FHV, FCV, and FPV vaccines, prepared from viruses grown in CRFK cells, could induce antibodies to cross-react with feline kidney tissues. The prevalence of autoantibodies that bound to kidney tissues in cats were 41% and 13% by ELISA and immunofluorescence, respectively; there was no direct link between vaccination and anti-kidney antibodies, but the presence of antibodies to kidney tissues was significantly associated with anti-FHV/-FCV/-FPV antibodies [ 108 ]. Although these studies suggest a possible association between vaccination and chronic kidney disease in cats, there is no causative evidence, and further studies are required.…”

Section: Cats With Other Immunosuppressive Diseasesmentioning

confidence: 99%

Vaccination of Immunocompromised Cats

Hartmann¹,

Möstl

Lloret

et al. 2022

Viruses

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Immunocompromise is a common condition in cats, especially due to widespread infections with immunosuppressive viruses, such as feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV), but also due to chronic non-infectious diseases, such as tumours, diabetes mellitus, and chronic kidney disease, as well as treatment with immunosuppressive drugs, such as glucocorticoids, cyclosporins, or tumour chemotherapy. In this review, the European Advisory Board on Cat Diseases (ABCD), a scientifically independent board of experts in feline medicine from eleven European countries, discusses the current knowledge and rationale for vaccination of immunocompromised cats. So far, there are few data available on vaccination of immunocompromised cats, and sometimes studies produce controversial results. Thus, this guideline summarizes the available scientific studies and fills in the gaps with expert opinion, where scientific studies are missing. Ultimately, this review aims to help veterinarians with their decision-making in how best to vaccinate immunocompromised cats.

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“…Another disease outcome is seen when neonatal kittens are infected, where virus infecting the cerebellum causes cerebellar hypoplasia and ataxia [ 244 ]. Recent work has revealed the structural features of the FPV capsid [ 245 ], the host-antibody responses [ 246 ], and the genetic variation in FPV sequences from many parts of the world [ 87 , 233 , 247 – 251 ]. Those studies have revealed the overall evolution of FPV, and helped to explain processes that underlie viral emergence, viral adaptation, and genetic variation.…”

Section: Genus Protoparvovirusmentioning

confidence: 99%

Small but mighty: old and new parvoviruses of veterinary significance

Jager

Tomlinson

Lopez-Astacio

et al. 2021

Virol J

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In line with the Latin expression “sed parva forti” meaning “small but mighty,” the family Parvoviridae contains many of the smallest known viruses, some of which result in fatal or debilitating infections. In recent years, advances in metagenomic viral discovery techniques have dramatically increased the identification of novel parvoviruses in both diseased and healthy individuals. While some of these discoveries have solved etiologic mysteries of well-described diseases in animals, many of the newly discovered parvoviruses appear to cause mild or no disease, or disease associations remain to be established. With the increased use of animal parvoviruses as vectors for gene therapy and oncolytic treatments in humans, it becomes all the more important to understand the diversity, pathogenic potential, and evolution of this diverse family of viruses. In this review, we discuss parvoviruses infecting vertebrate animals, with a special focus on pathogens of veterinary significance and viruses discovered within the last four years.

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Prevalence of autoantibodies that bind to kidney tissues in cats and association risk with antibodies to feline viral rhinotracheitis, calicivirus, and panleukopenia

Cited by 5 publications

References 41 publications

Calicivirus Infection in Cats

Calicivirus Infection in Cats

Vaccination of Immunocompromised Cats

Small but mighty: old and new parvoviruses of veterinary significance

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