Prevalence of autoantibodies in patients with endemic pemphigus foliaceus (fogo selvagem)

Nisihara, Renato; de, Ricardo Schmitt; Hausberger, Romeu; Roxo, Valéria Sperandio; Pavoni, Daniela Parada; Petzl-Erler, María Luiza; Messias-Reason, Iara José de

doi:10.1007/s00403-003-0412-9

Cited by 20 publications

(32 citation statements)

References 24 publications

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“…The presence of these autoantibodies may precede the clinical presentation, and a high autoantibody titer is usually associated with inflammatory flare-ups. The pathogenic role of antidesmoglein 1 antibodies in pemphigus foliaceus has been demonstrated by the blister production in experimental animals after injection of pemphigus foliaceus IgG [5, 6]; on the other hand, there are few reports that provide the frequency of antinuclear antibodies in pemphigus, however its frequency and pathogenic role in PE are still unknown [7, 8]. …”

Section: Introductionmentioning

confidence: 99%

Autoantibodies in Senear-Usher Syndrome: Cross-Reactivity or Multiple Autoimmunity?

Pérez-Pérez

Avalos‐Díaz

Herrera‐Esparza

2012

Autoimmune Diseases

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Senear-Usher syndrome or pemphigus erythematosus is a pathology that overlaps clinically and serologically with pemphigus foliaceus and lupus erythematosus. Skin biopsies of patients with pemphigus erythematosus reveal acantholysis and deposits of immunoglobulins in desmosomes, and they are positive in the lupus band test. In the present paper, we determined whether the autoantibodies associated with pemphigus erythematosus targeted a single antigen or multiple antigens as a result of the stimulation of independent B cell clones. Our present paper demonstrates that patients with pemphigus erythematosus produce both antiepithelial antibodies specific for desmoglein 1 and 3 and antinuclear antibodies specific for Ro, La, Sm, and double-stranded DNA antigens. After eluting specific anti-epithelial or anti-nuclear antibodies, which were recovered and tested using double-fluorescence assays, a lack of cross-reactivity was demonstrated between desmosomes and nuclear and cytoplasmic lupus antigens. This result suggests that autoantibodies in pemphigus erythematosus are directed against different antigens and that these autoantibodies are produced by independent clones. Given these clinical and serological data, we suggest that pemphigus erythematosus behaves as a multiple autoimmune disease.

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Section: Introductionmentioning

confidence: 99%

Autoantibodies in Senear-Usher Syndrome: Cross-Reactivity or Multiple Autoimmunity?

Pérez-Pérez

Avalos‐Díaz

Herrera‐Esparza

2012

Autoimmune Diseases

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“…It should be noted that a false-positive result from IIF in our study was obtained from sera of two patients with toxic epidermal necrolysis. Table 4 demonstrates the sensitivity and specificity of IIF on different substrates including ME, guinea pig esophagus, and human tissues on different locations of the body for the diagnosis of pemphigus [2,7,9,14,15,20,24,27,[32][33][34]37]. For the sensitivity of IIF in the diagnosis of PV, HC was comparable to ME and guinea pig esophagus.…”

Section: Discussionmentioning

confidence: 97%

Human cervix: an alternative substrate for detecting circulating pemphigus antibodies

et al. 2016

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Monkey esophagus (ME) is a well-accepted substrate for diagnosing pemphigus vulgaris (PV) by indirect immunofluorescence (IIF). However, its availability is sometimes limited due to ethical concerns. This study aimed to investigate the usefulness of human cervix (HC) as a substrate in the diagnosis of PV by IIF. Initially, serum from 1 PV patient was incubated with tissues from 48 HCs. Median IIF titers on HCs that had different demographic and clinical characteristics were compared. Sera from 5 PV patients were then incubated with ME and 21 HCs. For each serum, the titer of IIF on HC that was not different from ME by more than two-fold dilutions was acceptable. Last, sera from 42 PV, 14 pemphigus foliaceous, and 62 non-pemphigus patients were used to evaluate sensitivity and specificity. The results demonstrate that differences in demographic data among HCs did not affect IIF titers. Titers obtained from ME and HC were comparable (81-100 % acceptable values). Sensitivity of HC for diagnosis of PV was better than for diagnosis of pemphigus foliaceus (90.5 and 71.4 %, respectively). Specificity for PV and PF was 96.2 %. We proposed that HC substrate can be used as an alternative substrate for diagnosis of PV by IIF.

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“…The existence of ATD among patients with autoimmune diseases such as vitiligo, chronic urticaria, and autoimmune rheumatic diseases has been well recognized [14–17]. The simultaneous occurrence of different autoantibodies in different diseases does not seem to be coincidental but to result from similar immunopathogenic mechanisms involved in these disorders, which are still not completely understood [4, 18]. …”

Section: Discussionmentioning

confidence: 99%

Thyroid Autoimmunity and Behçet’s Disease: Is There a Significant Association?

Cebeci

Onsun

Pekdemir

et al. 2013

The Scientific World Journal

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Background. Behcet's disease (BD) could be regarded as an autoimmune disease in many aspects. Autoimmune thyroid disease (ATD) is frequently accompanied by other various autoimmune diseases. Nevertheless, there is not still enough data showing the association between BD and ATD. In addition, no controlled study is present in the PubMed, which evaluates thyroidal autoimmunity using antithyroid peroxidase antibody in a large series of patients with BD. Methods. We aimed to investigate the frequency of ATD in patients with BD. The study included 124 patients with BD and 99 age- and sex-matched healthy volunteers. Results. Autoimmune thyroiditis was noted in 21 cases (16.9%) with BD. In the control group, 22 cases (22.22%) were diagnosed as autoimmune thyroiditis. There was no difference between the groups in respect to thyroid autoantibodies (P > 0.05). There were no statistically significant differences between baseline TSH levels of the BD patients and of the controls (P > 0.05). Statistically, the mean serum free T4 levels of the patients with BD were higher than those of the controls (P < 0.001). Conclusions. No association could be found between BD and ATD. Therefore, it is not of significance to investigate thyroid autoimmunity in BD.

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Prevalence of autoantibodies in patients with endemic pemphigus foliaceus (fogo selvagem)

Cited by 20 publications

References 24 publications

Autoantibodies in Senear-Usher Syndrome: Cross-Reactivity or Multiple Autoimmunity?

Autoantibodies in Senear-Usher Syndrome: Cross-Reactivity or Multiple Autoimmunity?

Human cervix: an alternative substrate for detecting circulating pemphigus antibodies

Thyroid Autoimmunity and Behçet’s Disease: Is There a Significant Association?

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