Prevalence of Autism Spectrum Disorder in Preterm Infants: A Meta-analysis

Agrawal, Sachin; Rao, Shripada; Bulsara, Max; Patole, Sanjay

doi:10.1542/peds.2018-0134

Cited by 234 publications

(202 citation statements)

References 69 publications

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“…The Gardella et al (2017) study examined how the correlation between exposure to cyber-bullying and difficulties in achievement and attendance varied by gender, race/ethnicity, and age. Meta-analysis techniques also exist for the prevalence of a phenomenon across studies such as in estimating the prevalence of autism spectrum disorder in preterm infants (Agrawal, Rao, Bulsara, & Patole, 2018) and for diagnostic and prognostic test accuracy.…”

Section: Research Questions For a Meta-analysis Focus On Summarizing mentioning

confidence: 99%

Methodological Guidance Paper: High-Quality Meta-Analysis in a Systematic Review

Pigott

Polanin

2019

Review of Educational Research

322

256

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This methodological guidance article discusses the elements of a high-quality meta-analysis that is conducted within the context of a systematic review. Meta-analysis, a set of statistical techniques for synthesizing the results of multiple studies, is used when the guiding research question focuses on a quantitative summary of study results. In this guidance article, we discuss the systematic review methods that support high-quality meta-analyses and outline best practice meta-analysis methods for describing the distribution of effect sizes in a set of eligible studies. We also provide suggestions for transparently reporting the methods and results of meta-analyses to influence practice and policy. Given the increasing use of meta-analysis for important policy decisions, the methods and results of meta-analysis should be both transparent and reproducible.

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Section: Research Questions For a Meta-analysis Focus On Summarizing mentioning

confidence: 99%

Methodological Guidance Paper: High-Quality Meta-Analysis in a Systematic Review

Pigott

Polanin

2019

Review of Educational Research

322

256

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“…Prematurity is found in 9%–12% of births in the US. Although advances in neonatal medicine have decreased mortality of preterm birth, surviving infants are vulnerable to multiple morbidities, including increased risk for medical problems (Barfield, ), attention deficits, cognitive and language delays, disturbed executive function, autism spectrum disorder (Agrawal, Rao, Bulsara, & Patole, ), anxiety and depression (Field, ), and cognitive impairment (Brydges et al, ). Among the contributors to these outcomes are the effects of physical and emotional separation of infants and mothers during the neonatal intensive care unit (NICU) stay (Korja, Latva, & Lehtonen, ).…”

Section: Introductionmentioning

confidence: 99%

Autonomic regulation of preterm infants is enhanced by Family Nurture Intervention

Porges

Davila

Lewis

et al. 2019

Developmental Psychobiology

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Preterm infants have maturational delays in several neurobehavioral systems. This study assesses the impact of the Family Nurture Intervention (FNI) in the neonatal intensive care unit (NICU) on the maturation of autonomic regulation of preterm infants. Preterm infants born at 26–34 weeks postmenstrual age (PMA) were assigned to groups receiving either standard care (SC) or SC plus FNI, using a randomized controlled trial design. At two collection time points, approximately 35 weeks and 41 weeks PMA, electrocardiograms (ECG) were monitored for approximately 1 hour during sleep. Heart rate and respiratory sinus arrhythmia (RSA) were quantified from the ECG. Across the two time points, the FNI group exhibited greater increases in RSA (Cohen's d = 0.35) and slope between RSA and heart rate, as a measure of vagal efficiency (Cohen's d = 0.62). These results document that FNI resulted in enhanced autonomic regulation consistent with greater maturation of cardiac function. These and previous findings strongly suggest that facilitating early nurturing interactions and emotional connection between preterm infants and their mothers is a practicable and effective means of optimizing postnatal development in preterm infants. Interpretation of these autonomic function results also enriches our understanding of the potential long‐term beneficial outcomes of FNI by drawing upon polyvagal theory, which explains how autonomic state provides a neurophysiological platform for optimal co‐regulation between infant and caregiver, and by drawing upon calming cycle theory, which provides a model for understanding how repeated mother/infant calming interactions positively condition autonomic state and reinforce approach, prosocial behaviors.

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“…The former is where labor is induced or a Caesarean section is performed because of medical risks or complications, the latter where onset of labor occurs spontaneously prior to 37 weeks gestation. However, this distinction fails to take into impairments affecting multiple organ systems (Haraldsdottir et al, 2018;Huang, Lin, Wang, Su, & Lin, 2018;Parkinson, Hyde, Gale, Santhakumaran, & Modi, 2013), including potentially disabling neurological and neuropsychiatric disorders (Agrawal, Rao, Bulsara, & Patole, 2018;Franz et al, 2018;Heuvelman et al, 2018;Nosarti et al, 2012;Sutton & Darmstadt, 2013). This highlights the importance of determining the mechanisms behind preterm birth and how these mechanisms might relate to the difficulties faced later in life.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in the genetics of preterm birth

Wadon

Modi

Wong

et al. 2019

Annals of Human Genetics

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Preterm birth is associated with short‐ and long‐term impairments affecting physical, cognitive, and neuropsychiatric health. These sequelae, together with a rising preterm birth rate and increased survival, make prematurity a growing public health issue because of the increased number of individuals with impaired health throughout the life span. Although a major contribution to preterm birth comes from environmental factors, it is also modestly heritable. Little is known about the architecture of this genetic contribution. Studies of common and of rare genetic variation have had limited power, but recent findings implicate variation in both the maternal and fetal genome. There is some evidence risk alleles in mothers may be enriched for processes related to immunity and inflammation, and in the preterm infant, processes related to brain development. Overall genomic discoveries for preterm birth lag behind progress for many other multifactorial diseases and traits. Investigations focusing on gene–environment interactions may also provide insights, but these studies still have a number of limitations. Adequately sized genetic studies of preterm birth are a priority for the future especially given the breadth of its negative health impacts across the life span and the current interest in newborn genome sequencing.

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Prevalence of Autism Spectrum Disorder in Preterm Infants: A Meta-analysis

Abstract: The prevalence of ASD is significantly high in the preterm population. Adequate resources are needed to improve the outcomes of these children.

Cited by 234 publications

References 69 publications

Methodological Guidance Paper: High-Quality Meta-Analysis in a Systematic Review

Methodological Guidance Paper: High-Quality Meta-Analysis in a Systematic Review

Autonomic regulation of preterm infants is enhanced by Family Nurture Intervention

Recent advances in the genetics of preterm birth

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