Prevalence of atrial fibrillation in the general population of Japan: An analysis based on periodic health examination

Inoue, Hiroshi; Fujiki, Akira; Origasa, Hideki; Ogawa, Satoshi; Okumura, Ken; Kubota, Isao; Aizawa, Yoshifusa; Yamashita, Takeshi; Atarashi, Hirotsugu; Horie, Minoru; Ohe, Tohru; Doi, Yoshinori; Shimizu, Akihiko; Chishaki, Akiko; Saikawa, Tetsunori; Yano, Katsusuke; Kitabatake, Akira; Mitamura, Hideo; Kodama, Itsuo; Kamakura, Shiro

doi:10.1016/j.ijcard.2008.06.029

Cited by 362 publications

(246 citation statements)

References 32 publications

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“…The population with AF will significantly increase in the future with the increasingly aging society 1. In addition to the well‐known risk factors, including hypertension, diabetes mellitus, cardiovascular disease, obesity, metabolic syndrome, and chronic kidney disease, lifestyle characteristics such as alcohol consumption are significantly linked to the incidence and/or prevalence of AF 2, 3, 4, 5.…”

Section: Introductionmentioning

confidence: 99%

Impact of Alcohol Consumption on the Outcome of Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation

Takigawa

Takahashi

Kuwahara

et al. 2016

JAHA

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BackgroundAlthough several studies have reported an association between atrial fibrillation (AF) and alcohol, the impact of alcohol consumption on the outcome after catheter ablation (CA) for AF has not been discussed. We aimed to elucidate the effect of alcohol consumption on the outcome of CA for paroxysmal AF.Methods and ResultsWe examined 1361 consecutive patients with paroxysmal AF (mean age, 61±11 years, 334 women) who underwent CA, including 623 (45.8%) patients who consumed alcohol. The clinical characteristics and outcomes of CA were compared between patients who did and did not consume alcohol. No significant differences were seen in the left atrial size, duration of AF history, and incidence of nonpulmonary vein foci between 2 groups (P=NS). Although the AF recurrence‐free rate after the initial CA was higher in patients who did not consume alcohol (261/623 [41.9%] versus 252/738 [34.1%]; mean follow‐up, 44.4±30.7 months; P=0.003), the outcome after the final CA was similar between 2 groups (patients who consumed alcohol: 111/628 [17.7%] versus patients who did not consume alcohol: 138/738 [18.7%]; mean follow‐up, 53.1±25.8 months; P=0.67). The frequency (hazard ratio 1.07 per 1 day/week increase, CI 1.00–1.15, P=0.04) of alcohol consumption was significantly associated with AF recurrence after CA.ConclusionsThe frequency of alcohol consumption may be associated with AF recurrence after the initial CA for paroxysmal AF, but it may not affect the outcome after the final CA.

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Section: Introductionmentioning

confidence: 99%

Impact of Alcohol Consumption on the Outcome of Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation

Takigawa

Takahashi

Kuwahara

et al. 2016

JAHA

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“…The inclusion criteria were as follows : [1] patients admitted to the Cardiovascular Medicine Department of Yokosuka Kyousai Hospital for ablation of arrhythmias between March 2011 and July 2013 and who started WF therapy ; [2] duration of WF of "1 year ; [3] Prothrombin time -INR (PT-INR) measured at least once every 1!2 months (7) ; and [4] NVAF patients with heart failure. The exclusion criteria were patients with missing data and those who had NVAF without heart failure.…”

Section: Subjectsmentioning

confidence: 99%

“…It has also been reported that the number of such patients will surpass one million in 2030 (1). Cardiogenic cerebral embolism with AF greatly decreases patients' prognosis or quality of life compared with lacunar infarction and atherothrombotic brain infarction.…”

Section: Introductionmentioning

confidence: 99%

Hospital pharmacist intervention improves the quality indicator of warfarin control: A retrospective cohort study

Kose

Kikkawa

et al. 2017

J. Med. Invest.

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Background/Aims Our previous study showed that time in therapeutic range (TTR) control of warfarin therapy was negatively affected in non -valvular atrial fibrillation (NVAF) patients with heart failure. This study assesses the effect of intervention byhospital pharmacists on TTR control in Japanese NVAF patients with heart failure. Method This retrospective cohort study included NVAF patients with heart failure admitted and discharged from the cardiovascular internal medicine ward between March 2011 and July 2013. Participants were classified into two groups according to the instructions by hospital pharmacists and physicians (Intervention group) and by physicians only (Usual care group). The primary outcome was TTR. Secondary outcomes were major bleeding and minor bleeding. Results In total, 57 participants (35 males, 22 females ; mean age : 69.7 years) were classified into the Intervention (n = 25) and Usual care (n = 32) groups. TTR within-therapeutic range was significantly higher and within sub-therapeutic range was significantly lower in the Intervention than the Usual care group. Major bleeding and minor bleeding were not significantly different between the two groups. Conclusion The intervention of hospital pharmacists with anticoagulation therapy can lead to proper use of warfarin, which can be useful when physicians prescribe warfarin.

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“…12,13) Statins, possible prophylactic suppressors of the progression of atrial remodeling: In the present study which used an age-adjusted model, multivariate analysis indicated that the use of statins was the only signifi cant determinant for longer FCL in patients with new-onset AF. Because aging is an important risk factor for the clinical appearance as well as progression of AF, 3) the use of an age-adjusted model is necessary in this study. The signifi cant correlation between statin use and longer FCL observed in this study may indicate a prophylactic effect of statins for FCL shortening, at least in the cases with newonset AF.…”

Section: Detection Of New-onset Af In Clinical Studymentioning

confidence: 99%

Prophylactic Statin Administration May Prevent Shortening of the Fibrillation Cycle Length in Patients With New-Onset Atrial Fibrillation

Oikawa

Niwano

et al. 2013

Int. Heart J.

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SummaryPatients with recently diagnosed atrial fi brillation (AF) tend to exhibit a longer fi brillation cycle length (FCL) than those having a longer clinical history. However, the electrophysiological properties of new-onset AF may vary because of the clinical background of patients. In this study, we evaluated clinical factors to identify the determinants of FCL in new-onset AF. Electrocardiograms (ECGs) recorded from 2008 through 2011 were analyzed using our digital ECG-profi ling system. In the 1,578 AF episodes recorded, 466 new-onset AF episodes were identifi ed using clinical referral history and previous ECGs. After evaluating FCL in these new-onset AF episodes, using a customized fi brillation wave analyzer with fast Fourier transform analysis, we divided the patients into a longer-FCL group and a shorter-FCL group using the median FCL (158 ms). Propensity score matching yielded 135 matched pairs of patients with comparable mean ages between the two groups. Four factors (brain natriuretic peptide levels, and use of angiotensin receptor blockers, calcium channel blockers or statins) exhibited a signifi cant difference between the two groups. Multivariate analysis revealed that statin use was the only signifi cant independent predictor of longer FCL (Odds ratio, 3.86; 95% CI, 1.65-9.63; P = 0. and it is a major cause of morbidity and mortality in the general population.2) The prevalence of AF is related to aging, and there are approximately 716,000 people with AF in Japan, an overall prevalence of 0.56% in the Japanese population.3) The arrhythmogenic substrate of AF is known to be constructed progressively under various pathological conditions, including AF itself. This process is understood as atrial remodeling. Therapies designed to suppress this remodeling are termed "upstream therapy." Although the suppressive effects of some medicines, such as angiotensin receptor blockers (ARBs) 4,5) or statins, 6,7) as upstream therapy have been experimentally documented in animal models of AF, the clinical effect of this therapy is still controversial. [8][9][10] The reason for this discrepancy between experimental and clinical results remains unclear, but the atrial structural changes may have already progressed further in clinical cases than in experimental models, even in cases with paroxysmal AF, because of the infl uence of various clinical factors. We evaluated the atrial electrophysiological properties through analysis of the fi brillation cycle length (FCL).11) This method enables us to evaluate the degree of refractory shortening or the complexity of the AF substrate noninvasively and repeatedly, and then gives us indirect but important information about the degree of atrial remodeling.12) In the present study, we hypothesized that various clinical factors including those related to the disease underlying AF and/or the use of various prescribed medicines, may infl uence atrial electrophysiological properties even before the clinical appearance of AF. These clinical factors were compared between patients...

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Prevalence of atrial fibrillation in the general population of Japan: An analysis based on periodic health examination

Cited by 362 publications

References 32 publications

Impact of Alcohol Consumption on the Outcome of Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation

Impact of Alcohol Consumption on the Outcome of Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation

Hospital pharmacist intervention improves the quality indicator of warfarin control: A retrospective cohort study

Prophylactic Statin Administration May Prevent Shortening of the Fibrillation Cycle Length in Patients With New-Onset Atrial Fibrillation

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