Prevalence of atopic dermatitis in adults

Angles, María Valeria; Antonietti, Carolina; Torre, Ana Clara; Franzé, Estefanía Juszkiewicz; Mazzuoccolo, Luis Daniel; Parisi, Claudio Alberto Salvador

doi:10.1016/j.abd.2020.10.016

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…1,6 Esta afeta cerca de 15 a 20% das crianças e acomete 2 a 3% dos adultos. 10 Sabe-se que a DA de início precoce (entre 3 meses e 2 anos) é mais comum e corresponde entre 60% a 80% de todas as formas de início da doença. Destes, cerca de 40% prevalecem com a doença por um longo período de tempo e os demais apresentam remissão completa antes dos dois anos de idade.…”

Section: Discussionunclassified

Eritrodermia secundária a dermatite atópica grave: um relato de caso

Dias,

Lino,

Parente

et al. 2024

Braz. J. Hea. Rev.

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A eritrodermia é uma síndrome inflamatória grave que se apresenta com eritema cutâneo generalizado. As etiologias desta patologia são inúmeras e após determinar a causa base, adiciona-se às condutas iniciais o tratamento específico. Trata-se de estudo de caso de um adolescente de 13 anos, do sexo masculino, que apresentou quadro de eritrodermia secundária à dermatite atópica grave de difícil manejo, com prejuízo psicossocial. O controle só foi possível mediante imunossupressão sistêmica com ciclosporina, levando em consideração a refratariedade à terapia habitual.

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Section: Discussionunclassified

Eritrodermia secundária a dermatite atópica grave: um relato de caso

Dias,

Lino,

Parente

et al. 2024

Braz. J. Hea. Rev.

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“…La comorbilidad atópica más frecuente que observamos fue el asma en un tercio de los pacientes (29 %), coincidente con el grupo etario estudiado y a diferencia de pacientes adultos con DA, en los que la rinitis fue la comorbilidad más frecuente según Angles et al 8,9 Este resultado podría estar asociado al fenómeno de marcha atópica. 10,11 Al igual que lo observado por Calov M et al, [11][12][13] en el hemisferio norte y a lo referido por Yokomich H et al, en Japón, [11][12][13][14] los pacientes nacidos en otoño presentaron mayor prevalencia de DA.…”

Section: Discussionunclassified

Dermatitis atópica en niños y adolescentes asistidos en un hospital general de la Ciudad Autónoma de Buenos Aires

2023

Arch Argent Pediat

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Dermatitis atópica en niños y adolescentes asistidos en un hospital general de la Ciudad Autónoma de Buenos Aires RESUMENLa dermatitis atópica (DA) es una enfermedad inflamatoria de la piel de alta prevalencia en pediatría, de acuerdo a estudios internacionales. Existe escasa información sobre las características epidemiológicas en la población pediátrica Argentina.El objetivo fue describir la prevalencia y características clínicas de la DA en una población de niños argentinos atendidos en el servicio de pediatría de un hospital general.Estudio observacional, de corte transversal. Se incluyeron 500 pacientes al azar, media de edad de 10 años (DE 5), el 50 % (250) de sexo femenino, de los cuales 24 presentaron DA. La prevalencia global fue del 5 % (IC95 % 3-7) y 3/24 fueron formas graves. La comorbilidad atópica más frecuente fue asma.La DA es una enfermedad con una prevalencia en nuestra población similar a la de otros países. Nuestro estudio aporta nuevos datos acerca de las características epidemiológicas de la dermatitis atópica en nuestra región.

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“…Atopic dermatitis (AD) is a multifaceted and chronic inflammatory skin disease, representing one of the most prevalent skin disorders (1). Current estimates indicate that 10-20% of children and 3% of adults in developed countries are affected by this condition (1)(2)(3)(4). AD represents a highly heterogenous clinical and molecular phenotypes (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

“…Current estimates indicate that 10-20% of children and 3% of adults in developed countries are affected by this condition (1)(2)(3)(4). AD represents a highly heterogenous clinical and molecular phenotypes (4)(5)(6). While the pathogenesis of AD is not fully understood, the disorder is attributed to a combination of genetic and environmental factors, microbial imbalance, immune dysregulation, and abnormalities in the skin barrier (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Impact of fucosyltransferase 1-mediated epidermal blood group antigen H on anti-inflammatory response in atopic dermatitis

Li,

Oh,

Suh

et al. 2024

Front. Immunol.

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The presence of the blood group H2 antigen on the membrane of red blood cells determines blood type O in individuals and this H2 antigen serves as a precursor to the A and B antigens expressed in blood types A and B, respectively. However, the specific involvement of ABH antigens in skin diseases is unknown. Therefore, we aim to investigate the expression of ABH antigens in skin tissue of patients with atopic dermatitis (AD) and MC903-induced AD-like mice. We demonstrated that the expression of ABH antigen is primarily located in the granular and horny layers of the skin in healthy control individuals. However, in patients with AD, the expression of the ABH antigen was absent or diminished in these layers, while the H2 antigen expression increased in the spinous layers of the affected skin lesions. Then, we investigated the biological function of blood group H antigen mediated by fucosyltransferase 1 (Fut1) in the skin, utilizing an AD mouse model induced by MC903 in wild-type (WT) and Fut1-knockout mice. After the application of MC903, Fut1-deficient mice, with no H2 antigen expression on their skin, exhibited more severe clinical signs, increased ear swelling, and elevated serum IgE levels compared with those of WT mice. Additionally, the MC903-induced thickening of both the epidermis and dermis was more pronounced in Fut1-deficient mice than that in WT mice. Furthermore, Fut1-deficient mice showed a significantly higher production of interleukin-4 (IL-4) and IL-6 in skin lesions compared with that of their WT counterparts. The expression of chemokines, particularly Ccl2 and Ccl8, was notably higher in Fut1-deficient mice compared with those of WT mice. The infiltration of CD4+ T cells, eosinophils, and mast cells into the lesional skin was significantly elevated in Fut1-deficient mice compared with that in WT mice. These findings demonstrate the protective role of H2 antigen expression against AD-like inflammation and highlight its potential therapeutic impact on AD through the regulation of blood group antigens.

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Prevalence of atopic dermatitis in adults

Cited by 5 publications

References 9 publications

Eritrodermia secundária a dermatite atópica grave: um relato de caso

Eritrodermia secundária a dermatite atópica grave: um relato de caso

Dermatitis atópica en niños y adolescentes asistidos en un hospital general de la Ciudad Autónoma de Buenos Aires

Impact of fucosyltransferase 1-mediated epidermal blood group antigen H on anti-inflammatory response in atopic dermatitis

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