Prevalence of Asymptomatic Intraductal Papillary Mucinous Neoplasms in Healthy and Ill Populations Detected by Ultrasonography

Abstract

Objectives:The aim of this study was to establish the prevalence of intraductal papillary mucinous neoplasms (IPMNs) without and with highrisk stigmata (HRS)/worrisome features (WF) and the epidemiologic association between IPMNs and other diseases.Methods: Ultrasound examinations of outpatients were evaluated. The IPMN was confirmed by magnetic resonance imaging. The prevalence of IPMNs and HRS/WF IPMNs was calculated. The association between IPMNs and other diseases was studied. Results:The prevalence rate of IPMNs was 3.4%. A total of 1,531,264 IPMNs were expected in Italian population (2.5%), whereas 2257 per 100,000 citizens (2.3%) were expected in the European standard population (ESP2013). The prevalence rates of HRS/WF IPMNs were 0.5%, 0.7%, and 0.6%, in our, the Italian, and the ESP2013 populations, respectively. A total of 432,881 and 620 HRS/WF IPMNs per 100,000 residents were expected in the Italian and the ESP2013 populations, respectively. The IPMN prevalence increased over 50 years of age (odds ratio [OR], 3.2; P < 0.001) and over 70 years of age (OR, 1.9; P < 0.001). Female sex was related to the presence of IPMNs (OR, 1.9; P < 0.001).Conclusions: Intraductal papillary mucinous neoplasms had a high prevalence in asymptomatic nonhospitalized populations. Age older than 50 years identified a possible risk category.

Metabolic Syndrome Accelerates the Age-Related Increase of Intraductal Papillary Mucinous Neoplasm of the Pancreas

“…10 In these 2 studies, the risk factor associated with IPMNs was age, which was consistent with the findings of our study. In addition, in a study by Ricci et al, 12 the female sex was positively associated with the presence of IPMNs (OR, 1.9; P < 0.001), which was not examined in our study. We identified other factors associated with IPMN.…”

A Novel Scoring System to Improve the Detection Efficiency of Pancreatic Cystic Lesions in the General Population

“…(women: OR 1.9, p<0.001) were predictors of pancreatic cysts in a study of outpatients who underwent AUS(21). Although not significant, PCLs also tended to be more common in women than men in the present study as well (OR 1.55, 95% CI 0.94-2.56).…”

“…Furthermore, Soroida et al reported that gender (women: OR 1.29, p=0.001) as well as age were predictors of PCLs in a study of AUS examinees at medical checkups ( 20 ). Ricci et al also showed that age and gender (women: OR 1.9, p<0.001) were predictors of pancreatic cysts in a study of outpatients who underwent AUS ( 21 ). Although not significant, PCLs also tended to be more common in women than men in the present study as well (OR 1.55, 95% CI 0.94-2.56).…”

“…Previous studies have also investigated predictors of PCLs, and some factors have been reported. Of them, age is a well-known predictor of PCLs, and the detection rate of PCLs increases with age ( 3 , 18 - 21 ). Furthermore, Soroida et al reported that gender (women: OR 1.29, p=0.001) as well as age were predictors of PCLs in a study of AUS examinees at medical checkups ( 20 ).…”

Intraductal Papillary Mucinous Carcinoma Versus Conventional Pancreatic Ductal Adenocarcinoma: A Comprehensive Review of Clinical-Pathological Features, Outcomes, and Molecular Insights

“…IPMNs are grossly visible (typically > 5 mm) intraductal epithelial neoplasms of mucin-producing cells, first recognized by the World Health Organization (WHO) in 1996 [5]. IPMNs, that arise in the main pancreatic duct and/or their branches, are common lesions, with an estimated prevalence of 3-6% in the general population and more than 10% in older adults [6][7][8]. These tumors represent the most common pancreatic cystic neoplasms undergoing resection [9,10].…”