Prevalence of Asymptomatic Carotid Atherosclerotic Lesions Detected by High-Resolution Ultrasonography and Its Relation to Cardiovascular Risk Factors in the General Population of a Japanese City

Abstract

Our data showed that cardiovascular risk factors were strongly related to carotid atherosclerosis and that the proportion of severe carotid atherosclerosis with >50% stenosis was not low and was almost equal to that reported in developed western countries.

Normative values of carotid artery intima-media thickness in healthy Korean adults and estimation of macrovascular diseases relative risk using this data in type 2 diabetes patients

“…The carotid artery IMT is known to have a positive correlation with various atherosclerotic risk factors, such as age, blood pressure, total cholesterol, and LDLcholesterol [16][17][18][19][20]. The correlation coefficients between IMT and age (r = 0.520 in healthy subjects; r = 0.429 in diabetic patients) were similar to previous studies [21][22][23].…”

“…On the other hand, important decisive factors for IMT in T2DM patients are age, duration of diabetes, and LDL-cholesterol. Of all risk factors, age showed the strongest relationship with carotid atherosclerosis in both healthy subject and diabetic patients, as has also been shown in other reports [16,24].…”

“…We believe that the differences in age are responsible for the difference in these results. In other words, our study results represent IMTs of subjects over 30 years, who are older than those of the AXA study (17-65 years) [14], Deparion's study (20-60 years) [15], and younger than subjects of Mannami's study (50-79 years) [16].…”

“…In our study, the average IMTs for women and men older than 30 years were 0.667 AE 0.147 and 0.685 AE 0.156 mm, respectively. These are greater than results from the AXA study (0.51 AE 0.08 mm in women; 0.56 AE 0.12 mm in men) [14] and from Deparion's study (0.56 AE 0.06 mm in women; 0.57 AE 0.07 mm in men) [15] but less than Mannami's study (0.89 AE 0.11 mm in women; 0.92 AE 0.13 mm in men) [16]. We believe that the differences in age are responsible for the difference in these results.…”

Serum S-glutathionylated proteins as a potential biomarker of carotid artery stenosis

“…Many risk factors, such as hypertension, diabetes, obesity, dyslipidemia, smoking, and inflammation, have previously been reported to be associated with the development of CS [31]. Although multiple risk factors are likely to be more predictive than a single risk factor for CS [32], it is still difficult to identify patients with asymptomatic CS at the early stage of the disease.…”