Prevalence of asthma in patients with atopic dermatitis: A systematic review and meta-analysis

Ravnborg, Nanna; Ambikaibalan, Danni; Agnihotri, Gaurav; Price, Shmuel; Rastogi, Shipra; Patel, Kevin R.; Singam, Vivek; Andersen, Y.M.F.; Halling, Anne‐Sofie; Silverberg, Jonathan I.; Egeberg, Alexander; Thyssen, Jacob P.

doi:10.1016/j.jaad.2020.02.055

Cited by 51 publications

(42 citation statements)

References 68 publications

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“…The costs reported in this study are only those costs that can be attributed directly to AD. Costs that arise due to the numerous comorbidities of patients with AD 1,3,42,43 are, therefore, not included.…”

Section: Discussionmentioning

confidence: 99%

Cost‐of‐illness of atopic dermatitis in Germany: data from dermatology routine care

Mohr

Naatz

Zeervi

et al. 2021

Acad Dermatol Venereol

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Background Progress in the management of atopic dermatitis (AD) and the recent introduction of the first biologic have raised interest in the costs of treating AD.Objectives Since there is a lack of recent data, the objective of this study was to determine the annual costs of adults with AD from the societal perspective.Methods A nationwide cross-sectional study was conducted in 111 dermatological offices under routine conditions.Cost parameters were collected with a standardised questionnaire on disease-related costs. This questionnaire allows the determination of costs for systemic and topical treatment, outpatient and inpatient visits, rehabilitation stays and travel costs. Direct costs were determined for the statutory health insurance (SHI) and for the patients (out-of-pocket costs).Societal costs also included the indirect costs due to incapacity to work. Costs were calculated for all severity grades and further stratified by mild and moderate-to-severe AD.Results From August 2017 to June 2019, N = 1291 adult patients from all over Germany were included. The total annual costs in the group with all severity grades (n = 706) amounted to € 3616 AE € 6452 (median € 874) per patient. For patients with mild AD (n = 367), the annual costs were € 1466 AE € 3029 (median € 551) per patient, while they were € 5229 AE € 7538 (median € 1791) for patients with moderate-to-severe AD (n = 682). The total economic burden for treating adult patients with AD in Germany is estimated at more than € 2.2 billion. Conclusions In total, the data from this study show that compared to for example psoriasis, AD has a moderate level of costs-of-illness in Germany. The approval of new therapies is expected to lead to markedly more resource utilisation in the next years.

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Section: Discussionmentioning

confidence: 99%

Cost‐of‐illness of atopic dermatitis in Germany: data from dermatology routine care

Mohr

Naatz

Zeervi

et al. 2021

Acad Dermatol Venereol

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“…The prevalence of allergic diseases has been raised due to increased environmental and industrial exposures in recent decades [6][7][8]. Environmental factors play an important role in the pathogenesis of AR and other respiratory and skin allergic diseases [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Serum IgE Predicts Difference of Population and Allergens in Allergic Diseases: Data from Weifang City, China

Zhang

Guo

Wang

et al. 2021

Mediators of Inflammation

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Background. Immunoglobulin E (IgE) is the most important promoter of allergic inflammation. However, there are few systematic studies on IgE in age range, genders, disease spectrum, and time regularity. Aim. To screen the common allergens, allergen spectrum, and IgE difference between type 2 inflammatory allergic diseases and other allergic diseases in Weifang, China. Methods. A retrospective study was performed by estimating patients’ clinical data suffering from allergic diseases (urticaria, pollinosis, allergic rhinitis, atopic dermatitis, and bronchial asthma) between May 2019 and April 2020 using an allergen detection kit of Macro-Union Pharmaceutical. Results. 732 of the 1367 patients showed different antigen positive, and the positive rate was 53.5%. The most common allergens were dust mites, mixed fungi, Artemisia pollen, cat/dog dander, and cockroaches. There were 27.0% (369/1367) of the patients with single positive allergen-specific IgE (sIgE), 26.5% (363/1367) with multiple-positive IgE. The total immunoglobulin E (tIgE) levels varied with gender, age, and type of disease. There was a difference in the distribution of allergens between children and adults. A positive correlation between the serum-specific IgE and the corresponding local inhaled allergen density was observed. Conclusions. In this study, we found that type 2 inflammatory allergic diseases have higher serum IgE and a higher probability of inhaled sIgE positive. According to age, gender, and condition, serological IgE detection of allergens provides new insight into the early diagnosis and prevention of allergic diseases.

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“…6,7 There is a shared immune response in asthmatic and AD patients with type 2 immunity and raised IgE levels and this may to some extent explain their coexistence. 8,9 We found that out of 65 patients who suffered from asthma 59 (90.7%) had AD and 13 (14.2%) patients who suffered from AD also had chest infections. Even though chest infection alone may not be responsible for triggering or causing AD but it has been shown in various studies that patients having asthma and AD are more prone to infections.…”

Section: Resultsmentioning

confidence: 81%

Referrals from Paediatric Department with Respiratory Symptoms having Skin Lesions

Jha

Budhathoki

Shakya

et al. 2021

J. Nepal Paedtr. Soc.

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Introduction: Paediatric patients with respiratory symptoms having skin lesions are often referred from Paediatric to Dermatology Department. Knowledge about skin and respiratory manifestations will lead to early diagnosis and proper management by the doctors of both the specialties. These dermatological conditions may or may not be related to respiratory illness or may hence be part of total disease process or may be completely separate entity. The aim of this study was to find out skin manifestations of various respiratory diseases and analyse dermatological disorders in children referred from Paediatric Department having respiratory symptoms. Methods: An observational cross sectional hospital based study involving inpatients and outpatients referred from Paediatrics to Dermatology Department having respiratory illness and skin lesions was undertaken between January 2019 to December 2020. Details of skin disease were recorded. The descriptive statistical analysis was expressed in frequency and percentage and Chi square test was applied to determine significance among variables. Results: Total 437 patients were included in the study. The most common diagnosis made by Paediatric {160 (36.6%)} and Dermatology Departments {246 (56.2%) was viral exanthema followed by atopic dermatitis {77 (17.6%)}. Out of total 65 patients who suffered from bronchial asthma, 59 (90.7%) patients had atopic dermatitis. Conclusions: Significant paediatric patients with respiratory illnesses have concomitant skin lesions. There is very high percentage of patients having atopic dermatitis among those who had asthma and hence clearly depicts relation between the two diseases.

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Prevalence of asthma in patients with atopic dermatitis: A systematic review and meta-analysis

Cited by 51 publications

References 68 publications

Cost‐of‐illness of atopic dermatitis in Germany: data from dermatology routine care

Cost‐of‐illness of atopic dermatitis in Germany: data from dermatology routine care

Serum IgE Predicts Difference of Population and Allergens in Allergic Diseases: Data from Weifang City, China

Referrals from Paediatric Department with Respiratory Symptoms having Skin Lesions

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